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Xuanfei Baidu decoction, a Chinese herbal medicine for coronavirus disease 2019 (COVID-19): a randomized clinical trial
Tao Li, Min Zhao, Mingjun Zhu, Shixi Zhang, Jiarong He, He Pan, Mingyi Shao, Zhen Wang, Yu Fu, Ning Li, Long Zhao, Xinyao Jin, Fengwen Yang, Wentai Pang
PDF(643 KB)
PDF(643 KB)
Xuanfei Baidu decoction, a Chinese herbal medicine for coronavirus disease 2019 (COVID-19): a randomized clinical trial
Objective: To evaluate the efficacy and safety of Xuanfei Baidu decoction for treating coronavirus disease 2019 (COVID-19).
Methods: Patients with COVID-19 were enrolled, and eligible patients were randomly allocated to three groups: group A (Xuanfei Baidu decoction combined with conventional treatment), group B (Ganlu Xiaodu decoction combined with conventional treatment), and group C (conventional treatment only). The duration of treatment was 14 days. The primary outcomes were the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid testing from positive to negative and hospitalization days. The secondary outcome was the rate of symptom resolution. The safety outcome was drug-related adverse events.
Results: In total, 103 patients with ordinary-type COVID-19 were included and randomly allocated to groups A (34 cases), B (35 cases), and C (34 cases). Duration for SARS-CoV-2 nucleic acid testing from positive to negative was shortest in group A [(9.88 ± 3.62) days], followed by groups C [(11.20 ± 2.93) days] and B [(12.69 ± 4.11) days]; differences between the three groups were statistically significant (P = 0.010). The number of hospitalization days was the least in group A [(14.00 ± 6.55) days], followed by groups B [(15.40 ± 4.02) days] and C [(16.38 ± 5.73) days], and differences between groups were statistically significant (P = 0.019). There was no statistically significant difference in the rate of symptom resolution between groups (P > 0.05). No deaths or serious adverse events occurred in either of the groups.
Conclusion: Considering the treatment of ordinary-type COVID-19, Xuanfei Baidu decoction can shorten the duration from a positive to negative SARS-CoV-2 nucleic acid test, as well as the duration of hospitalization. Moreover, there were no Xuanfei Baidu decoction-induced adverse reactions.
COVID-19 / Ordinary type / Randomized clinical trial / Traditional Chinese medicine / Xuanfei Baidu decoction
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