Expert consensus on the clinical application of Xuanfei Baidu granule
Qingquan Liu, Hongchun Zhang, Chengxiang Wang, Qing Miao, Fengwen Yang, Yuhong Huang, Wenke Zheng
Expert consensus on the clinical application of Xuanfei Baidu granule
Xuanfei Baidu granule is an effective prescription for COVID-19, which is modified from classical famous prescriptions. In order to further standardize clinician’s rational use of Xuanfei Baidu granule, enhance clinical efficacy, improve rational medication level, and let it play a more significant role, the frontline clinical experts are invited for discussion on the major functions, usage, adverse reactions, and considerations of Xuanfei Baidu granule to form the consensus. The consensus is that: Xuanfei Baidu granule has the efficacy of promoting the lung and resolving dampness, clearing heat and removing pathogeneses, purging the lung and depoisoning; it can be used for the treatment of patients with mild, moderate, and heavy COVID-19 and other common upper respiratory tract infectious diseases such as influenza; acute tracheitis and bronchitis and community-acquired lower respiratory tract infectious diseases all belong to damp-toxin constraint in the lungs, Xuanfei Baidu granule can relieve cough, expectoration, and other symptoms caused by an acute exacerbation of the chronic obstructive pulmonary disease, with definite clinical efficacy and good safety. According to the principles of evidence-based medicine, this expert consensus will be updated regularly.
Clinical application / COVID-19 / Expert consensus / Xuanfei Baidu granule
[[1]] |
Gao J, Xiao GX, Fan GW, et al. Clinical and pharmacological research progress of “Three Drugs and Three Prescriptions” in the treatment of COVID-19. Chin Sci Bull 2022;67(27):3296-3310.
|
[[2]] |
Zheng WK, Zhang JH, Zhang J, et al. Investigation and analysis of traditional Chinese medicine syndromes of 2 135 Patients with Novel Coronavirus Pneumonia. J Tradit Chin Med 2021;62(16):1413-1415.
|
[[3]] |
China Association of Traditional Chinese Medicine Respiratory Medicine Research Committee. Novel Coronavirus Pneumonia expert consensus on prevention and treatment of Chinese patent medicine. Chin J Integr Tradit West Med 2022;42(3):294-297.
|
[[4]] |
General Office of the National Health Commission, Office of National Administration of Traditional Chinese Medicine. Notice on printing and distributing the Novel Coronavirus Pneumonia diagnosis and treatment scheme (trial ninth edition). Available from:
|
[[5]] |
Li XC, Zhang J, Xia W, et al. Clinical Observation of Xuanfei Baidu decoction in treating severe patients of Novel Coronavirus Pneumonia. Chin J Chin Mater Med. 2022;47(13):3667-3674.
|
[[6]] |
Pang WT, Yang FW, Zheng WK, et al. Evaluation of clinical efficacy of Xuanfei Baidu granule in treating Omicron strain infected Novel Coronavirus Pneumonia. Tianjin J Tradit Chin Med. 2022;39(9):1093-1098.
|
[[7]] |
Feng LM, Liu XY, Zhang L. Clinical observation of Xuanfei Baidu granule in treating Novel Coronavirus Pneumonia (Omicron). Tianjin J Tradit Chin Med. 2022;39(5):545-550.
|
[[8]] |
Xiong WZ, Wang G, Du J, et al. Efficacy of herbal medicine (Xuanfei Baidu decoction) combined with conventional drug in treating COVID-19: a pilot randomized clinical trial. Integr Med Res 2020;9(3):100489.
|
[[9]] |
Zhou L, Wang XN, Liu XK, et al. Case peport of Xuanfei Baidu prescription curing severe patients of Novel Coronavirus Pneumonia. Tianjin J Tradit Chin Med. 2021;38(5):556-559.
|
[[10]] |
Bi YF, Ma ZR, Yang XD, et al. Modified Xuanfei Baidu prescription used to treat 2 severe patients of Novel Coronavirus Pneumonia. J Tradit Chin Med 2022;63(2):198-200.
|
[[11]] |
Pan X, Dong L, Yang L, et al. Potential drugs for the treatment of the novel coronavirus pneumonia (COVID-19) in China. Virus Res 2020;286:198057.
|
[[12]] |
Li L, Wu Y, Wang J, et al. Potential treatment of COVID-19 with traditional Chinese medicine: what herbs can help win the battle with SARSCoV-2? Engineering 2021;8:20.
|
[[13]] |
Yan H, Lu J, Wang J, et al. Prevention of cyclophosphamide-induced immunosuppression in mice eith traditional Chinese medicine Xuanfei Baidu decoction. Front Pharmacol 2021;12:730567.
|
[[14]] |
Wang Y, Sang X, Shao R, et al. Xuanfei Baidu decoction protects against macrophages induced inflammation and pulmonary fibrosis via inhibting IL-6/STAT3 signaling pathway. J Ethnopharmacol 2022;30:114701.
|
[[15]] |
Wang Y, Wang X, Li Y, et al. Xuanfei Baidu decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway. Pharmacol Res 2022;176:106083.
|
[[16]] |
Li Z, Pan H, Yang J, et al. Xuanfei Baidu formula alleviates impaired mitochondrial dynamics and activated NLRP3 inflammasome by repressing NF-κB and MAPK pathways in LPS-induced ALI and inflammation models. Phytomedicine 2023;108:154545.
|
[[17]] |
Zhu Y, Luo L, Zhang M, et al. Xuanfei Baidu formula attenuates LPS-induced acute lung injury by inhibiting the NF-κB signaling pathway. J Ethnopharmacol 2023;30:115833.
|
[[18]] |
Ma L, Zhao X, Liu T, et al. Xuanfei Baidu decoction attenuates intestinal disorders by modulating NF-κB pathway, regulating T cell immunity and improving intestinal flora. Phytomedicine 2022;101:154100.
|
[[19]] |
Wang H, Song HX, Wang DF, et al. Exploration of the potential mechanism of Xuanfei Baidu decoration in treating Novel Coronavirus Pneumonia based on network pharmacology and molecular docking. J Hainan Med Univ. 2020;26(18):1361-1372.
|
[[20]] |
Xue YJ, Qu B, Shao R, et al. Analysis of the mechanism of Xuanfei Baidu prescription in treating SARS, MERS and COVID-19 based on network pharmacology. Drugs and Clinic 2021;36(12):2473-2487.
|
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