Rhizoma polygonati from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger

Lazzat Nurtay, Qinglei Sun, Chenglin Mu, Zhongshan Cao, Qian Wang, Zongsuo Liang, Cuiping Ma, Xugang Li, Amr Amin, Yingqiu Xie

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Acupuncture and Herbal Medicine ›› 2021, Vol. 1 ›› Issue (1) : 31-38. DOI: 10.1097/HM9.0000000000000008
Review Articles
Review Articles

Rhizoma polygonati from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger

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Abstract

Recently, traditional Chinese medicine-based treatment has succeeded in fighting coronavirus disease 2019 (COVID-19), and Rhizoma polygonati (Huangjing) has been one of the recommended components. Its processed products play antidiabetic, antiviral, antitumor, antioxidation, antifatigue, antiaging, and immune enhancement roles. The climate in Mount Tai is mild, and the dense forest is suitable for the growth of Rhizome polygonati, which has gradually evolved into a unique specie. Considering the important medicinal value and pleasant taste of Mount Tai-Rhizoma polygonati, various healthy and functional food products, controlled by quality markers with anti-COVID-19 potential, as well as emergency foods can be developed. The study aimed to review current evidence on the nutritional value of Rhizoma polygonati from Mount Tai and its usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and food shortage. Most recent findings regarding herbal nanomedicine have revealed that nanoscale chemical compounds are potentially efficient in drug delivery or nanozyme catalysis upon bioprocessing. Nanoflower structure is found in processed Rhizoma polygonati by self-assembly and has wide application in enzymatic events, particularly nanoscale herbzyme. The novel findings regarding Mount Tai-Rhizoma polygonati could enhance its novel applications in chronic and hidden hunger, clinical nanomedicine, and as an anti-COVID-19 agent.

Keywords

Chemical composition / Coronavirus disease 2019 / Pharmacology / Rhizome polygonati

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Lazzat Nurtay, Qinglei Sun, Chenglin Mu, Zhongshan Cao, Qian Wang, Zongsuo Liang, Cuiping Ma, Xugang Li, Amr Amin, Yingqiu Xie. Rhizoma polygonati from Mount Tai: nutritional value and usefulness as a traditional Chinese medicine, source of herbzyme, and potential remediating agent for COVID-19 and chronic and hidden hunger. Acupuncture and Herbal Medicine, 2021, 1(1): 31‒38 https://doi.org/10.1097/HM9.0000000000000008

References

[[1]]
Le G, Wu PP, Chen LS.Research progress of high-yield cultivation techniques of Jiuhua Rhizome polygonati. Anhui Sci Technol 2013;26(11):24-26.
[[2]]
Chen XR, Chen L, Ma ZM.The medicinal value and development of Dian Rhizome polygonati. Med Herald 2003;22(4):261-263.
[[3]]
Wang GH, Wang Q, Shi YL.Taishan four famous medicines.Shandong J Tradit Chin Med 2006;25(3):203-204.
[[4]]
Mu XL, Zhang LM, Yang SX, et al.Study on tissue culture and rapid propagation technology of Taishan wild Rhizome polygonati. Shandong Agric Sci 2010;48(1):12-13.
[[5]]
Tian QJ, Zhao Z, Gu FG.Study on the phenological period of cultivated Rhizome polygonati. Chin Med Mater 2010;33(2):168-169.
[[6]]
Tian QJ, Zhao Z, Gu FG.Research on Rhizome polygonati cultivation technology. Hubei Agric Sci 2011;50(4):772-776.
[[7]]
Li ST, Kong Q, Che Y, et al.Study on resource distribution and applied cultivation of Taishan Rhizome polygonati. China For Ind 2016;7:115.
[[8]]
Gong JH, Bi YW, Yang YH, et al.Study on the growth and development characteristics of rhizome winter buds in Taishan area.Shandong Agric Sci 2010;48(1):43-44.
[[9]]
Zong Y.Study on germination characteristics of rhizome of Taishan Rhizome polygonati. Anhui Agric Sci Bull 2009;15(23):171-172.
[[10]]
Sun WS, Chen WX, Zhu LX, et al.Effects of low temperature and gibberellin on germination characteristics of Taishan Rhizome polygonati seeds. Shandong Agric Sci 2019;51(11):64-67.
[[11]]
Gu ZW.Advances in research of cultivation techniques of Rhizome polygonati. Qilu Pharm Aff 2012;31(6):358-359.
[[12]]
Li S, Guo XJ, Su SX, et al.Study on high-yield and high-efficiency cultivation techniques of wild varieties of Rhizome polygonati. China J Chin Mater Med 1997;7(22):398-401.
[[13]]
Bi YW, Gong JH, Yang YH.Study on comprehensive cultivation techniques of Taishan Rhizome polygonati. Chinese Agric Sci Bull 2005;51(12):280-282.
[[14]]
Zhao Z, Pang YX, Yuan Y, et al.Advances in research on cultivation of medicinal plantRhizome polygonati and several key issues in cultivation. Guizhou Agric Sci 2005;34(1):85-86.
[[15]]
Zhang Z.Taishan Rhizome polygonati and its high-yield cultivation. Chin Local Prod 1996;13(6):11.
[[16]]
Tian QJ, Zhao Z, Gu FG.Study on the phenological period of cultivated Polygonatum.Chin Med Mater 2010;33(2):168-170.
[[17]]
Yang J.Overview of the significance of introduction and domestication of medicinal plants.World Latest Med Inform Dig 2016;16(A2):26-27.
[[18]]
Zhang P.Artificial cultivation techniques of Taishan Rhizome polygonati. Shandong Forest Sci Technol 2002;32(5):28-29.
[[19]]
Li ST, Fan LG, Gao LX, et al.Habitat investigation and introduction of wild Rhizome polygonati from Taishan. Spec Econ Anim Plants 2016;19(10):39-40.
[[20]]
Yang ZX, Shi YL, Zhang ZY, et al.Study on the dissolution rate of some trace elements in the decoction of Taishan Rhizome polygonati Salvia miltiorrhiza Bupleurum bambusa. Trace Elem Health Res 1996;4:33-34.
[[21]]
Zhang L, Xia ZL.Analysis and determination of trace elements in Taishan Rhizome polygonati. China Med Herald 2007;26:105-106.
[[22]]
Lu JR, Li Z, Wu RT, et al.Study on the dissolution law of trace metal elements in Taishan Rhizome polygonati. Food Sci Technol 2006;25(9):96-99.
[[23]]
Wang SD, Song BS, Jin YL, et al.Analysis of trace elements and amino acids in rhizoma rhizome and fibrous roots.Chin Pat Med 2001;24(5):59-60.
[[24]]
Xu BB, Yu YJ, Wu F, et al.Review on the research of polysaccharides from rhizoma rhizome.China Wild Plant Resour 2015;34(4):38-41, 46.
[[25]]
Pang YX, Zhao Z, Yuan Y, et al.The chemical composition and pharmacological effect of rhizoma rhizome.J Mt Agric Biol 2003;11(6):547-550.
[[26]]
Gong JN, Yun CY, Wu J, et al.Study on extraction optimization and antioxidant activity of Polygonatum polysaccharide.J Guizhou Norm Univ 2019;37(3):18-23.
[[27]]
Yuan LR, Ye YL.Study on anti-oxidation effect of Polygonatum polysaccharide in vitro.Strait Pharm 2020;32(2):18-21.
[[28]]
Wang Y, Dong P, Jin CZ, et al.Composition of Polygonatum sibiricum polysaccharide and analysis of its antioxidant activity. Genom Appl Biol 2019;38(5):2191-2199.
[[29]]
Fang HL, Li XM, Li QQ, et al.Study on extraction of Polygonatum polysaccharide and its antioxidant effect.Biochem Ind 2018;4(3):11-15.
[[30]]
He XM, Li C, Li YZ, et al.Determination of Polygonatum sibiricum polysaccharide from different producing areas and study on its antioxidant activity in vitro. J West Anhui Univ 2018;34(5):89-92.
[[31]]
Wang QL, Tong XH, Li XD, et al.Effect of Polygonatum polysaccharide on STZ-induced type I diabetic mice.J Yunnan Coll Tradit Chin Med 2019;42(1):1-7.
[[32]]
Jia L, Shi J, Duan ZQ, et al.Effect of Polygonatum polysaccharide on glucose metabolism function in diabetic mice induced by high fat feed.China Med Herald 2017;14(8):24-28.
[[33]]
Wang Y, Peng GQ, Jiang XQ, et al.Study on the protective mechanism of Huangjing polysaccharide on diabetic rat model.Chin Med Herald 2017;23(2):8-16.
[[34]]
Zhang ZY, Wang GX, Chen TT, et al.Effect of rhizoma rhizome polysaccharide on myocardial fibrosis in diabetic rats.China Pub Health 2016;32(6):807-810.
[[35]]
Zhao HL, Xu Y, Zhao HY, et al.Effect of Polygonatum polysaccharide on the expression of SREBP-1c and SCD-1 protein in type 2 diabetic rats.Pharmacol Clin Chin Mater Med 2015;31(1):106-109.
[[36]]
Yan WL, Pu Q, Meng YW.Preparation of two polysaccharide derivatives of polygonatum and comparison of their antiviral activities.Nat Prod Res Develop 2000;5:60-65.
[[37]]
Shi L, Meng YW, Li W.Pharmacological study of rhizoma rhizome and rhizoma rhizome polysaccharide.Nat Prod Res Develop 1999;3:67-71.
[[38]]
Liu N.Study on the isolation, identification and immunomodulatory effect of Polygonatum polysaccharide. Shandong: Shandong Univ; 2017.
[[39]]
Ye SF.Effects of rhizoma rhizome polysaccharide on thymus index, spleen index, T lymphocyte subsets and phagocytic function of exhausted exercise mice.Genom Appl Biol 2015;34(1):60-65.
[[40]]
Yang QX.Steroidal Saponins from Five Medicinal Liliaceous Plants.Diss, Kunming Kunming Institute of Botany. Chinese Academy of Sciences 1999.
[[41]]
Li XC, Yang CR, Ichikawa M.Steroid saponins from Polygonatum kingianum. Phytochemistry 1992;31(10):3559-3563.
[[42]]
Jian JM.Chemical study on the composition of four lily cluster medicinal plants. Yunan: Kunming Inst Bot; 2003.
[[43]]
Wang J, Yue YD, Tang F, et al.Analysis of volatile components before and after processing rhizoma rhizome.China J Chin Mater Med 2011;36(16):2187-2191.
[[44]]
Chen XR, Wang CJ, Li LX, et al.Advances in research on chemical constituents and pharmacology of Dian rhizoma rhizome.Shi Zhen Natl Med 2002;9:560-561.
[[45]]
Zhang XX, Tang YT, Tang L, et al.Research progress of rhizoma rhizome's processing and quality analysis.Mod Chin Doct 2018;56(22):165-168.
[[46]]
Feng WS. Effect of Processing on Polysaccharide Content in Rhizoma Rhizome. Proceedings of the National Symposium on Research and Application of Polysaccharide Drugs of the Chinese Pharmaceutical Association. 2008;Professional Committee of Biochemical and Biotechnology Medicines of Chinese Pharmaceutical Association: Chinese Pharmaceutical Association, 44-147.
[[47]]
Wang XD, Tian F, Shi GY, et al.Comparison of polysaccharide content in rhizoma rhizome from different places.J Taishan Med Coll 2008;9:657-658.
[[48]]
Yang SX, Yang ZM, Chen YJ, et al.Changes of polysaccharide and saponin contents in rhizoma rhizome after “Nine Steamed Nine Made” process.J Hunan Norm Univ 2015;12(5):141-144.
[[49]]
Wang Q, Liu X, Xu M, et al.Study on the changes of steroidal saponins during the preparation of rhizoma rhizome.Yunnan J Tradit Chin Med 2017;38(5):72-75.
[[50]]
Zhong LY, Zhang Y, Huo HJ, et al.A Preliminary study on the changes of composition and drug effect of rhizoma rhizome before and after processing.Chin Med Mater 2011;34(10):1508-1511.
[[51]]
Wu QG, Hu YQ, Fan Z, et al.Research progress of the effect of processing on the chemical composition of rhizoma rhizome.J Baotou Med Coll 2018;34(1):128-129, 133.
[[52]]
Zhang YX, Zhou Q, Zhang XL, et al.Study on the changes and conversion mechanism of oligosaccharides and monosaccharides before and after rhizoma rhizome processing.Chin Med Mater 2020;2:318-322.
[[53]]
Wang C, Song ZQ, Ning ZC, et al.Study on the Maillard reaction product of dichloromethane prepared by Huang Jing and its antioxidant activity.Chin Herb Med 2019;50(3):604-610.
[[54]]
Zhao P, Zhao C, Li X, et al.The genus Polygonatum: a review of ethnopharmacology, phytochemistry and pharmacology.J Ethnopharmacol 2018;214:274-291.
[[55]]
Zhang C, Wei CF, Jia FL, et al.Study on Taishan rhizoma rhizome's effect on urethane-induced lung cancer and anti-inflammatory in mice.J Taishan Univ 2013;35(3):113-116.
[[56]]
Qi B, Ding T, Chang ZY, et al.Anti-aging effects of Taishan rhizoma rhizome on d-galactose-induced aging mice.Shi Zhen Natl Med 2010;21(7):1811-1812.
[[57]]
Li YL, Wang DC, Shi RJ, et al.Isolation, identification and antibacterial activity of endophytic fungi from Taishan rhizoma rhizome.Chin Herb Med 2013;44(11):1490-1494.
[[58]]
Yang HY, Huang QL, Liu ZL, et al.Isolation of an endophytic fungus from Taishan rhizoma rhizome and a preliminary study on its antioxidant activity.J Taishan Med Coll 2017;38(10):1081-1083.
[[59]]
Guo LD.Research progress of endophyte.Mycobact Syst 2017;38(10):1081-1083.
[[60]]
Wang YF.Research progress of plant endophytes.Mod Hortic 2019;11:23-24.
[[61]]
Jiao R, He PF, Wang G, et al.Study on colonization ability of endophyte YN201728 and its effect of controlling tobacco powdery mildew.J Nucl Agric 2020;34(4):721-728.
[[62]]
Lan Q, Ji ZQ, Gu AG, et al.Preliminary study on insecticidal and bactericidal active substances in endophytic fungi of bitter vine.J Northwest A & F Univ 2004;10:79-84.
[[63]]
Bai XH, Liu XL, Liu D, et al.Isolation, identification and antibacterial activity of an endophyte from rhizoma rhizome.Nat Prod Res Develop 2018;30(5):777-782.
[[64]]
Chi HR, Zhang YH, Zeng X, et al.Isolation, identification and antibacterial and promoting effects of endophytic bacillus Polygonatum.Plant Protect 2019;45(4):122-131.
[[65]]
Jiang CX, Zhang TJ, Chen CQ, et al.Research progress of rhizoma rhizome and prediction analysis of its quality markers.Chin Herb Med 2017;48(1):1-16.
[[66]]
Bi YW, Yang YH, Gong JH, et al.Determination of polysaccharide and diosgenin in rhizoma rhizome and Polygonatum.J Changchun Univ Tradit Chin Med 2010;26(5):649-650.
[[67]]
Zhou BZ.Study on the content of diosgenin in Dioscorea zingiberensis from different places. Shanxi Agric Sci 2017;63(8):42-45.
[[68]]
Li L, Tian LN, Ren ZX, et al.Research progress of structure analysis and functional activity of Polygonatum polysaccharide.Chin J Exp Pharmacol 2015;21(15):231-234.
[[69]]
Gao HL, Qu XL, Su YY.Ultrasonic extraction and content determination of polysaccharide in Taishan rhizoma rhizome.J Taishan Med Coll 2006;27(2):151-152.
[[70]]
Zhu YW, Zhu L, Chen QS. The Chemical Composition, Pharmacological Effect and Product Development of Rhizoma Rhizome. Compilation of papers of the 6th National Conference on Integrated Chinese and Western Medicine Nutrition.Chongqing: Nutrition Committee of Chinese Society of Integrated Traditional Chinese and Western Medicine; 2015.
[[71]]
Zhang L, Xia ZL.Analysis and determination of trace elements in Taishan rhizoma rhizome.China Med Herald 2007;4(26):105-106.
[[72]]
Zhang L.Principal component analysis of trace elements in rhizoma rhizome from different places.Trace Elem Health Res 2009;26(6):19-21.
[[73]]
Hollingsworth PM, Forrest LL, Spouge JL.A DNA barcode for land plant.Proc Natl Acad Sci USA 2009;106(31):12794-12797.
[[74]]
Chen S, Yao H, Han J, et al.Validation of the ITS2 region as a novel DNA barcode for identifying medicinal plant species.PLoS One 2010;5(1):e8613.
[[75]]
Jiao J, Huang WL, Bai ZQ, et al.DNA barcoding for the efficient and accurate identification of medicinal Polygonati rhizome in China. PLoS One 2018;13(7):e0201015.
[[76]]
Štorchová H, Olson MS.The architecture of the chloroplast PsbA-trnH non-coding region in angiosperms.Plant Syst Evol 2007;268:235-256.
[[77]]
Zhang HM.ISSR analysis of genetic diversity of rhizoma rhizome germplasm resources in Anhui Province. Anhui: Anhui Agric Univ; 2013.
[[78]]
Vijayan K.Inter simple sequence repeat (ISSR) polymorphism and its application in mulberry genome analysis.Int J Indust Entomol 2005;2(10):79-865.
[[79]]
Jiao J, Jia XR, Liu P, et al.Species identification of Polygonati rhizoma in China by both morphological and molecular marker methods. Plant Biol Pathol 2018;341:102-110.
[[80]]
Bi YW, Gong JH, Yang YH.The medicinal value and cultivation techniques of Taishan rhizoma rhizome.Anhui Agric Bull 2006;8:86-87.
[[81]]
Bi YW, Gong JH, Yang YH.Research on artificial cultivation techniques of Taishan rhizoma rhizome.Chin Med Res Inform 2005;7(9):33-36.
[[82]]
Wang XJ, Zhu WH, Wang XL.Analysis on the meteorological features of fog weather in Mount Jiuhua.J Anhui Agric Sci 2012;40(15):8655-8755.
[[83]]
Sun J, Feng J, Duan W.Change in the urban heat island effect in Kunming.Clim Environ Res (in Chinese) 2015;20(6):645-653.
[[84]]
Zhejiang Meteorological Bureau. Available from: http://zj.cma.gov.cn/. Accessed 15 March, 2020.
[[85]]
Tai’an Municipal Government. Available from: http://sd.cma.gov.cn/gslb/tasqxj/qxfw/. 2019. Accessed 15 April, 2020.
[[86]]
Zhang Y, Yin HM.Comparative analysis on climate characteristics of Mountain Tai in Tai‘an city.Environ Sustain Develop 2016;41(5):217-219.
[[87]]
Yang W, Liu M.Xinhua Polygonatum Becomes the “Loudi Element” to Help Fight the Epidemic. Sina.com. Available from: https://k.sina.com.cn/article_2687386043_a02e41bb02000rw26.html.from=news&subch=onews. Accessed 24 March, 2020.
[[88]]
Zhejiang University - Handbook of COVID-19 Prevention and Treatment. Available from: https://video-intl.alicdn.com. Accessed 18 March, 2020.
[[89]]
Chinese Forestry Society. Forest Medicinal Materials Play an Important Role in Fighting the Epidemic. Available from: http://www.csf.org.cn/News/noticeDetail.aspx?aid=48267. Accessed 17 April, 2020.
[[90]]
Notice of Qingdao Municipal Health Commission on Issuing the “Guiding Opinions of Qingdao New Coronary Pneumonia Experts on Traditional Chinese Medicine Health Management. ” Available from: http://wsjkw.qingdao.gov.cn/n28356065/n32563120/n32563123/n32563126/200229124856749143.html. Accessed 28 February, 2020.
[[91]]
Tongji Hospital of Huazhong University of Science and Technology. Five TCM coups for home rehabilitation of patients with new coronary pneumonia. Available from: https://www.hubei.gov.cn/zhuanti/2020/gzxxgzbd/fkkp/202003/t20200310_2177544.shtml. Accessed 10 March, 2020.
[[92]]
Mu CL, Sheng YF, Wang Q, et al.Potential compound from herbal food of rhizoma polygonati for treatment of COVID-19 analyzed by network pharmacology and molecular docking technology.J Funct Foods 2021;77:104149.
[[93]]
Mu CL, Sheng YF, Wang Q, et al.Dataset of potential Rhizoma polygonati compound-druggable targets and partial pharmacokinetics for treatment of COVID-19. Data Brief 2020;33:106475.
[[94]]
Ru JL, Li P, Wang J, et al.TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.J Cheminform 2014;6:13.
[[95]]
Daina A, Michielin O, Zoete V.SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules.Nucleic Acids Res 2019;47(W1):W357-W364.
[[96]]
Szklarczyk D, Gable AL, Lyon D, et al.STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.Nucleic Acids Res 2019;47(D1):D607-D613.
[[97]]
Shannon P, Markiel A, Ozier O, et al.Cytoscape: a software environment for integrated models of biomolecular interaction networks.Genome Res 2003;13(11):2498-2504.
[[98]]
Dai L, Liu K, Si C, et al.Ginsenoside nanoparticle: a new green drug delivery system.J Mater Chem B 2016;4(3):529-538.
[[99]]
Li T, Wang P, Guo W, et al.Natural berberine-based chinese herb medicine assembled nanostructures with modified antibacterial application.ACS Nano 2019;13(6):6770-6781.
[[100]]
Gao L, Zhuang J, Nie L, et al.Intrinsic peroxidase-like activity of ferromagnetic nanoparticles.Nat Nanotechnol 2007;2(9):577-583.
[[101]]
Benassi E, Fan HY, Sun QL, et al.Generation of particle assemblies mimicking enzymatic activity by processing of herbal food: the case of rhizoma polygonati and other natural ingredients in traditional Chinese medicine.Nanoscale Adv 2021;3(8):2222-2235.
[[102]]
Kabulova A, Razbekova M, Xie YQ, et al.Nanoscale Huangjing extract from Mount Tai displays enzyme and biofuel enhancing activity: Potential in precision anti-cancer therapy [abstract]Cancer Res 2020;80(16):
[[103]]
Pan J, Lu W, Chen S, et al. Characterization of the complete chloroplast genome of Polygonatum sibiricum (Liliaceae), a well-known herb to China. Mitochondrial DNA B Resour 2020;5(1):528-529.
[[104]]
Chen D, Han Z, Si J.Huangjing ( Polygonati rhizoma) is an emerging crop with great potential to fight chronic and hidden hunger. Sci China Life Sci 2021;17:1-3.

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