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2024 , Vol. 5 >Issue 1: 406

DOI: https://doi.org/10.1002/agt2.406

Click-hydrogel delivered aggregation-induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds

  • Xu Chen 1 ,
  • Meijiao Zhao 2 ,
  • Qihu Xie 3 ,
  • Sitong Zhou 4 ,
  • Xiaoping Zhong 3 ,
  • Judun Zheng 2 ,
  • Ronghua Yang , 5 ,
  • Xianjin Du , 6 ,
  • Jinyu Xia , 1 ,
  • Yuhui Liao , 2
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  • 1. Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, China
  • 2. Molecular Diagnosis and Treatment Center for Infectious Diseases, Dermatology Hospital, Southern Medical University, Guangzhou, China
  • 3. Department of Burns and Plastic Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China
  • 4. Department of Dermatology, The, First People’s Hospital of Foshan, Foshan, China
  • 5. Department of Burn and Plastic Surgery, Guangzhou First People’s Hospital, South China University of Technology, Guangzhou, China
  • 6. Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China
eyyangronghua@scut.edu.cn
duxianjin@whu.edu.cn
xiajinyu@mail.sysu.edu.cn
liaoyh8@mail.sysu.edu.cn

Received date: 27 Jul 2023

Accepted date: 08 Aug 2023

Copyright

2023 2023 The Authors. Aggregate published by SCUT, AIEI, and John Wiley & Sons Australia, Ltd.
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Abstract

As a high-risk trauma, deep burns are always hindered in their repair process by decreased tissue regeneration capacity and persistent infections. In this study, we developed a simultaneous strategy for deep burn wounds treatment using functional nanovesicles with antibacterial and tissue remodeling properties, delivered via a click-chemistry hydrogel. An aggregation-induced emission photosensitizer of 4-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1-(2-hydroxyethyl) pyridin-1-ium bromide (THB) with excellent photodynamic properties was first prepared, and then combined with readily accessible adipose stem cells-derived nanovesicles to generate the THB functionalized nanovesicles (THB@ANVs). The THB@ANVs showed strong antibacterial activity against Gram-positive bacteria (up to 100% killing rate), and also beneficial effects on tissue remodeling, including promoting cell migration, cell proliferation, and regulating immunity. In addition, we prepared a click-hydrogel of carboxymethyl chitosan for effective delivery of THB@ANVs on wounds. This hydrogel could be injected to conform to the wound morphology while responding to the acidic microenvironment. In vivo evaluations of wound healing revealed that the THB@ANVs hydrogel dressing efficiently accelerated the healing of second-degree burn wounds by reducing bacterial growth, regulating inflammation, promoting early angiogenesis, and collagen deposition. This study provides a promising candidate of wound dressing with diverse functions for deep burn wound repair.

Key words： aggregation-induced emission; burn wounds; nanovesicles

Cite this article

Xu Chen , Meijiao Zhao , Qihu Xie , Sitong Zhou , Xiaoping Zhong , Judun Zheng , Ronghua Yang , Xianjin Du , Jinyu Xia , Yuhui Liao . Click-hydrogel delivered aggregation-induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds[J]. Aggregate, 2024 , 5(1) : 406 . DOI: 10.1002/agt2.406

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