Wave Mechanics of Ciliary Proteins: Quantum-Enabled Sensing and Energy Transfer in the “Cellular Antenna”

Abstract

Cilia and their nucleating bodies, centrioles, are enigmatic structures in cell biology. The immotile primary cilium, lacking the motor proteins required to drive fluid flow, was widely considered vestigial throughout the 20th century; in sharp contrast, the modern understanding is that primary cilia are central to sensation, cellular differentiation, and metazoan development. This revolution has been guided by advances in molecular biology, high-resolution imaging, and the strict conservation of the cilia-centriole apparatus from the last eukaryotic common ancestor, empowering studies of model organisms across distant evolutionary lineages. Contemporaneously, the role of quantum mechanics in biology has progressed from trivial applications in bioorganic chemistry to the suspicion that life can tunnel, entangle, and establish extended quantum coherences within diverse families of proteins and nucleic acids. In explorations of eukaryotic quantum biology, many of the current protein systems of interest are found within the highly regulated microenvironment of the cilium, a geometrically precise aggregate. Consequently, we argue that understanding the cilium-centriole complex will require bridging classical biology with emerging quantum biophysics. In this review, we introduce the essential elements of quantum biology alongside the emerging frontiers of ciliary biology, aiming to facilitate interactions between these fields with an eye toward developing testable hypotheses of how nature may take advantage of quantum mechanics in this unique cellular environment.

Keywords

aromatic compounds / chirality / cilia / cytoskeleton / hierarchy / radical pair

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