Correction: Hydrophobic Carbon Dots Prevent α-Synucleinopathy and Suppress Neuroinflammation to Treat Parkinson's Disease
Lihua Li , Yao Lu , Xiangling Ye , Chi Zhang , Jialin Liu , Zhongmin Yang , Jianhua Hao
Aggregate ›› 2025, Vol. 6 ›› Issue (11) : e70202
The aggregation of α-synuclein (ɑ-syn) coupled with overexpressed neuroinflammation instigates the degeneration of dopaminergic neurons, thereby aggravating the progression of Parkinson's disease (PD). Herein, we introduced a series of hydrophobic amino acid-based carbon dots (CDs) for inhibiting ɑ-syn aggregation and mitigating the inflammation in PD neurons. Significantly, we show that phenylalanine CDs (Phe-CDs) could strongly bind with ɑ-syn monomers and dimers via hydrophobic force, maintain their stability, and inhibit their further aggregation in situ and in vitro, finally conferring neuroprotection in PD by rescuing synaptic loss, ameliorating mitochondrial dysfunctions, and modulating Ca2+ flux. Importantly, Phe-CDs demonstrate the ability to penetrate the blood–brain barrier, significantly improving motor performance in PD mice. Our findings suggest that Phe-CDs hold great promise as a therapeutic agent for PD and the related neurodegenerative disease.
amino acid / carbon dots / neuroinflammation / Parkinson's disease / α-synuclein aggregation
2025 The Author(s). Aggregate published by SCUT, AIEI, and John Wiley & Sons Australia, Ltd.
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