Multifunctional and Sprayable 2D MoS2/Silk Sericin Bio-Nanocomposite Dressings with Enhanced Photothermal Effect for Infected Wound Healing
Libin Qiu, Lian Duan, Hongyu Lin, Min Wang, Huaping Liang, Guilong Peng, Xiao Yang, Yang Si, Shixiong Yi
Advanced Fiber Materials ›› 2024, Vol. 6 ›› Issue (4) : 1074-1091.
Multifunctional and Sprayable 2D MoS2/Silk Sericin Bio-Nanocomposite Dressings with Enhanced Photothermal Effect for Infected Wound Healing
Developing novel antibacterial dressing protecting skin injuries from infection is essential for wound healing. In this study, sericin, a bio-waste produced during the degumming of silk cocoons, is utilized to exfoliate MoS2 layers and improve the dispersity and stability of MoS2 nanosheets (MoS2-NSs). Moreover, owing to its ability to promote oxygen permeability and cell growth and its good biocompatibility, MoS2-NS/Sericin maintains its photothermal property under an 808 nm light source for a strong antibacterial activity as well as improves the fibroblast migration, which accelerates wound healing. Furthermore, the in vitro experiments indicates that MoS2-NS/Sericin can also scavenge reactive oxygen species (ROS) at an inflammatory stage of wound healing and transform classical activated macrophages (M1-type) into alternatively activated macrophages (M2-type), which is beneficial for wound recovery. Based on these results observed in vitro, full-thickness skin wound experiments are conducted on rats, and the corresponding results show that MoS2/Sericin under 808 nm irradiation exhibits the best performance in promoting wound healing. Overall, MoS2-NS/Sericin exhibits a high potential for bacteria-infected wound healing.
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