Progress of research on delaying bone destruction of rheumatoid arthritis by combining traditional Chinese and Western medicine

Dier Jin , Yuanyuan Xu , Wenwen Qi , Tianyi Lan , Ting Liu , Rihong Liu , Zihan Wang , Yuan Xu

Adv. Chi. Med ›› 2025, Vol. 2 ›› Issue (3) : 120 -133.

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Adv. Chi. Med ›› 2025, Vol. 2 ›› Issue (3) :120 -133. DOI: 10.1002/acm4.70003
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Progress of research on delaying bone destruction of rheumatoid arthritis by combining traditional Chinese and Western medicine

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Abstract

Rheumatoid arthritis (RA) is a common autoimmune disease with bone destruction as the core pathology, which belongs to the category of "impediment disease" in traditional Chinese medicine (TCM), and its etiology and pathogenesis are still not completely clear. It is characterized by high prevalence, high disability rate, and high recurrence rate, which seriously affects human health and has become a worldwide research hot spot. At present, although modern medicine has made significant progress in the treatment of RA bone destruction, such as biologics and small-molecule targeted drugs, it still faces problems such as poor efficacy, drug resistance, drug side effects, and long-term treatment costs. It has been found that the use of TCM decoction and acupuncture in combination with Western medicine for the treatment of RA bone destruction can enhance the efficacy of the treatment while reducing the adverse effects of Western medicine. However, no one has systematically reviewed the current research status on the combination of Chinese and Western medicine in the treatment of RA bone destruction. Therefore, this paper reviews the research progress of combined Chinese and Western medicine in the treatment of RA bone destruction, aiming to promote the application of combined Chinese and Western medicine in clinical practice and provide new treatment ideas for the clinical treatment of RA bone destruction.

Keywords

bone destruction / combination of traditional Chinese and Western medicine / rheumatoid arthritis / traditional Chinese medicine

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Dier Jin, Yuanyuan Xu, Wenwen Qi, Tianyi Lan, Ting Liu, Rihong Liu, Zihan Wang, Yuan Xu. Progress of research on delaying bone destruction of rheumatoid arthritis by combining traditional Chinese and Western medicine. Adv. Chi. Med, 2025, 2(3): 120-133 DOI:10.1002/acm4.70003

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References

[1]

Gao A , Wu R , Mu Y , et al. Restoring immune tolerance in pre- RA:immunometabolic dialogue between gut microbiota and regulatory T cells. Front Immunol. 2025; 16: 1565133.

[2]

Uke P , Maharaj A , Adebajo A . A review on the epidemiology of rheumatoid arthritis:an update and trends from current literature. Best Pract Res Clin Rheumatol. 2025; 39 (1): 102036.

[3]

National Clinical Research Center for Dermatologic and Immunologic Diseases (Peking Union Medical College Hospital) , Chinese Association of Rheumatology and Immunology Physicians ; Rheumatology and Immunology Professional Committee of Chinese Rehabilitation Medical Association , Rheumatology and Immunology Professional Committee of Chinese Research Hospital Association , Rheumatology and Immunology Branch of Beijing Association of Holistic Integrative Medicine . 2024 Chinese guidelines for the diagnosis and treatment of rheumatoid arthritis. Chin J Intern Med. 2024; 63 (11): 1059- 1077 (in Chinese).

[4]

Zhao JY , Zhao F , Qu BJ , Song Y , Fu LY . Current status and trend analysis of disease burden of rheumatoid arthritis China from 1990 to 2019. Chin J Health Statistics. 2024; 41 (3): 344- 348+353 (in Chinese).

[5]

GBD 2021 Other Musculoskeletal Disorders Collaborators . Global, regional, and national burden of other musculoskeletal disorders, 1990-2020, and projections to 2050:a systematic analysis of the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023; 5 (11): e670- e682.

[6]

Hsieh PH , Wu O , Geue C , McIntosh E , McInnes IB , Siebert S . Economic burden of rheumatoid arthritis:a systematic review of literature in biologic era. Ann Rheum Dis. 2020; 79 (6): 771- 777.

[7]

Cai X , Zheng Y , Ren F , Zhang S , Wu L , Yao Y . Secretory phosphoprotein 1 secreted by fibroblast-like synoviocytes promotes osteoclasts formation via PI3K/AKT signaling in collagen-induced arthritis. Biomed Pharmacother. 2022; 155: 113687.

[8]

Yang M , Zhu L . Osteoimmunology:the crosstalk between T cells, B cells, and osteoclasts in rheumatoid arthritis. Int J Mol Sci. 2024; 25 (5): 2688.

[9]

Wang F , Yang G , Li Y , et al. A peptide from wheat germ abolishes the senile osteoporosis by regulating OPG/RANKL/RANK/TRAF6 signaling pathway. Phytomedicine. 2022; 104: 154304.

[10]

Pascual-García S , Martínez-Peinado P , Pujalte-Satorre C , et al. Exosomal osteoclast-derived miRNA in rheumatoid arthritis:from their pathogenesis in bone erosion to new therapeutic approaches. Int J Mol Sci. 2024; 25 (3): 1506.

[11]

Yokota K , Sato K , Miyazaki T , et al. Characterization and function of tumor necrosis factor and Interleukin-6-Induced osteoclasts in rheumatoid arthritis. Arthritis Rheumatol. 2021; 73 (7): 1145- 1154.

[12]

Kitaura H , Marahleh A , Ohori F , et al. Role of the interaction of tumor necrosis Factor-α and tumor necrosis factor receptors 1 and 2 in bone-related cells. Int J Mol Sci. 2022; 23 (3): 1481.

[13]

Takeuchi T , Yoshida H , Tanaka S . Role of interleukin-6 in bone destruction and bone repair in rheumatoid arthritis. Autoimmun Rev. 2021; 20 (9): 102884.

[14]

Grassi W , Okano T , Di Geso L , Filippucci E . Imaging in rheumatoid arthritis:options, uses and optimization. Expet Rev Clin Immunol. 2015; 11 (10): 1131- 1146.

[15]

Barile A , Arrigoni F , Bruno F , et al. Computed tomography and MR imaging in rheumatoid arthritis. Radiol Clin. 2017; 55 (5): 997- 1007.

[16]

Aletaha D , Neogi T , Silman AJ , et al. 2010 Rheumatoid arthritis classification criteria:an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum. 2010; 62 (9): 2569- 2581.

[17]

Nurmohamed MT , Dijkmans BA . Efficacy, tolerability and cost effectiveness of disease-modifying antirheumatic drugs and biologic agents in rheumatoid arthritis. Drugs. 2005; 65 (5): 661- 694.

[18]

Smolen JS , Steiner G . Therapeutic strategies for rheumatoid arthritis. Nat Rev Drug Discov. 2003; 2 (6): 473- 488.

[19]

Zhao M , Ma JR , Li L , Wang YH , Li Y . Progress of research on the etiology and treatment of rheumatoid arthritis in Chinese medicine. Gansu Med J (Gansu Yiyao). 2024; 43 (12): 1057- 1060 (in Chinese).

[20]

Chang C , Zhang RR , Shi YM , He DY . Research progress of traditional Chinese medicine in the treatment of rheumatoid arthritis. Chin J Tradit Chin Med (Zhongguo Zhongyao Zazhi). 2023; 48 (2): 329- 335 (in Chinese).

[21]

Xing Q , Fu L , Yu Z , Zhou X . Efficacy and safety of integrated traditional Chinese medicine and Western medicine on the treatment of rheumatoid arthritis:a meta-analysis. Evid Based Complement Alternat Med. 2020; 2020 (1): 4348709.

[22]

Zhao Z , Hua Z , Luo X , et al. Application and pharmacological mechanism of methotrexate in rheumatoid arthritis. Biomed Pharmacother. 2022; 150: 113074.

[23]

Breedveld FC , Dayer JM . Leflunomide:mode of action in the treatment of rheumatoid arthritis. Ann Rheum Dis. 2000; 59 (11): 841- 849.

[24]

Ding WW , Jiang ZS , Cheng PP , Ma SC . Effect of methotrexate combined with leflunomide on immune function and bone cytokines in patients with rheumatoid arthritis. Chin J Gerontol (Zhongguo Laonian Xue Zazhi). 2024; 44 (10): 2408- 2412 (in Chinese).

[25]

Kour G , Haq SA , Bajaj BK , Gupta PN , Ahmed Z . Phytochemical add-on therapy to DMARDs therapy in rheumatoid arthritis:in vitro and in vivo bases, clinical evidence and future trends. Pharmacol Res. 2021; 169: 105618.

[26]

Wijnands MJ , van Riel PL . Management of adverse effects of disease-modifying antirheumatic drugs. Drug Saf. 1995; 13 (4): 219- 227.

[27]

Garrison L , McDonnell ND . Etanercept:therapeutic use in patients with rheumatoid arthritis. Ann Rheum Dis. 1999; 58 (Suppl 1): I65- I69.

[28]

Moreland LW , Schiff MH , Baumgartner SW , et al. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med. 1999; 130 (6): 478- 486.

[29]

Gulyás K , Horváth Á , Végh E , et al. Effects of 1-year anti-TNF- α therapies on bone mineral density and bone biomarkers in rheumatoid arthritis and ankylosing spondylitis. Clin Rheumatol. 2020; 39 (1): 167- 175.

[30]

Lebouille-Veldman AB , Huizinga TWJ , Mekary RA , Vleggeert-Lankamp CLA . Infliximab use and cervical spine deformity in patients with rheumatoid arthritis. RMD Open. 2025; 11 (1): e005237.

[31]

Chen TL , Chang KH , Su KY . Effects of biological/targeted therapies on bone mineral density in inflammatory arthritis. Int J Mol Sci. 2022; 23 (8): 4111.

[32]

Karsdal MA , Schett G , Emery P , et al. IL-6 receptor inhibition positively modulates bone balance in rheumatoid arthritis patients with an inadequate response to anti-tumor necrosis factor therapy:biochemical marker analysis of bone metabolism in the tocilizumab RADIATE study (NCT00106522). Semin Arthritis Rheum. 2012; 42 (2): 131- 139.

[33]

Pierguidi S , Bertoldi I , Adinolfi A , et al. AB0535 effects of tocilizumab on bone density and metabolism in patients with active rheumatoid arthritis. Ann Rheum Dis. 2013; 71 (S3): 668.

[34]

Kitano M , Kitano S , Docea M , et al. SAT0119 effect of abatacept on bone homeostasis and osteopontin in rheumatoid arthritis. Ann Rheum Dis. 2013; 72 (Suppl 3): A621.

[35]

van Mulligen E , Weel AE , Hazes JM , van der Helm-van Mil A , de Jong PHP . Tapering towards DMARD-free remission in established rheumatoid arthritis:2-year results of the TARA trial. Ann Rheum Dis. 2020; 79 (9): 1174- 1181.

[36]

Smolen JS , Landewé RBM , Bergstra SA , et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs:2022 update. Ann Rheum Dis. 2023; 82 (1): 3- 18.

[37]

Barbosa LSP , Ely MM , Salomé TM , et al. Fungal infections associated with TNF-inhibitors:a 20-year of a systematic review fungal infections and TNF-inhibitors. Mycoses. 2025; 68 (3): e70040.

[38]

Picchianti-Diamanti A , Aiello A , De Lorenzo C , Migliori GB , Goletti D . Management of tuberculosis risk, screening and preventive therapy in patients with chronic autoimmune arthritis undergoing biotechnological and targeted immunosuppressive agents. Front Immunol. 2025; 16: 1494283.

[39]

Waldron JL , Schworer SA , Kwan M . Hypersensitivity and immune-related adverse events in biologic therapy. Clin Rev Allergy Immunol. 2022; 62 (3): 413- 431.

[40]

Angelini J , Talotta R , Roncato R , et al. JAK-inhibitors for the treatment of rheumatoid arthritis:a focus on the present and an outlook on the future. Biomolecules. 2020; 10 (7): 1002.

[41]

Komagamine M , Komatsu N , Ling R , et al. Effect of JAK inhibitors on the three forms of bone damage in autoimmune arthritis:joint erosion, periarticular osteopenia, and systemic bone loss. Inflamm Regen. 2023; 43 (1): 44.

[42]

Li CH , Xu LL , Jian LL , et al. Stattic inhibits RANKL-mediated osteoclastogenesis by suppressing activation of STAT3 and NF-κB pathways. Int Immunopharmacol. 2018; 58: 136- 144.

[43]

Li C , Sun Y , Xu W , Chang F , Wang Y , Ding J . Mesenchymal stem cells-involved strategies for rheumatoid arthritis therapy. Adv Sci (Weinh). 2024; 11 (24): e2305116.

[44]

Sarsenova M , Issabekova A , Abisheva S , Rutskaya-Moroshan K , Ogay V , Saparov A . Mesenchymal stem cell-based therapy for rheumatoid arthritis. Int J Mol Sci. 2021; 22 (21): 11592.

[45]

Lee BW , Kwok SK . Mesenchymal stem/stromal cell-based therapies in systemic rheumatic disease:from challenges to new approaches for overcoming restrictions. Int J Mol Sci. 2023; 24 (12): 10161.

[46]

Wang Q , Peng X , Gao X , et al. Peptide-oligonucleotide nanohybrids designed for precise gene therapy of rheumatoid arthritis. Adv Mater. 2025; 37 (18): e2500883.

[47]

Ke X , Xie Q , Luo S , Li Q , Zheng Q , Zhang Z . Intra-articular delivery of an AAV-anti-TNF-α vector alleviates the progress of arthritis in a RA mouse model. Hum Gene Ther. 2024; 35 (17-18): 754- 766.

[48]

Tsitrouli Z , Akritidou MA , Genitsaris S , Willigen GV . Treatment of rheumatoid arthritis with gene therapy applications:biosafety and bioethical considerations. BioTech (Basel). 2021; 10 (3): 11.

[49]

Zhang HG , Jia JX , Liu HY , Li QS . Research advances of gene therapy technology for rheumatoid arthritis. J Jilin Univ (Sci Ed). 2025; 63 (1): 216- 228 (in Chinese).

[50]

Wu JK , Wang YY , Zhang FF , Li X , Wang YM . Research progress of traditional Chinese medicine for rheumatoid arthritis based on the principle of "treating the same disease differently". Tianjin J Tradit Chin Med (Tianjin Zhongyi Yao). 2023; 40 (6): 790- 799 (in Chinese).

[51]

Wei WY , Luo YD , Li FC , Pang XY , Tan AQ . Progress of research on the classical famous formula of remission of Juan Bi Tang. J Basic Chin Med (Zhongguo Zhongyi Jichu Yixue Zazhi). 2024; 30 (12): 2134- 2140 (in Chinese).

[52]

Li ZW . Observations on the therapeutic effect of Bu Shen Jia Wei Juan Bi Tang in the adjuvant treatment of rheumatoid arthritis. J Practical Tradit Chin Med (Shiyong Zhongyi Yao Zazhi). 2022; 38 (7): 1142- 1143 (in Chinese).

[53]

Xia Y , Fan D , Li X , et al. Yi Shen Juan Bi Pill regulates the bone immune microenvironment via the JAK2/STAT3 signaling pathway in vitro. Front Pharmacol. 2021; 12: 746786.

[54]

Wang T , Jia Q , Chen T , et al. Alleviation of synovial inflammation of Juanbi-Tang on collagen-induced arthritis and TNF- Tg mice model. Front Pharmacol. 2020; 11: 45.

[55]

Wang C , Liu P , Qiu XP . Research on modern clinical application and experimental research of Baihu Guizhi decoction. Clin J Chin Med (Zhongyi Linchuang Yanjiu). 2021; 13 (6): 122- 125 (in Chinese).

[56]

Wu Y , Wu YH , Ding Q , Liu W . Mechanism of Xuanbi decoction in treatment of rheumatoid arthritis based on network pharmacology. Liao Ning J Chin Med (Liaoning Zhongyi Zazhi). 2020; 47 (11): 6- 12+221 (in Chinese).

[57]

Li W , Mao X , Wang X , et al. Disease-modifying anti-rheumatic drug prescription Baihu-Guizhi decoction attenuates rheumatoid arthritis via suppressing toll-like receptor 4-mediated NLRP3 inflammasome activation. Front Pharmacol. 2021; 12: 743086.

[58]

Chen Q , Yang J , Chen H , Pan T , Liu P , Xu SJ . Inhibition Ras/MEK/ERK pathway:an important mechanism of Baihu Jia Guizhi Decoction ameliorated rheumatoid arthritis. J Ethnopharmacol. 2023; 304: 116072.

[59]

Zhou SB . Clinical observation of modified Taohong decoction in treating rheumatoid arthritis (stagnation arthritis type). Henan University of Chinese Medicine; 2021 (in Chinese).

[60]

Tang R , Yang HX , Wan DP , Fan XH . Research progress of Duhuo Jisheng decoction in the treatment of rheumatoid arthritis. J Liaoning Univ of TCM (Liaoning Zhongyi Yao Daxue Xuebao). 2024; 26 (7): 174- 179 (in Chinese).

[61]

Zhao HY , Du X , Xu HX , Zhang HT . Action mechanism of Duhuo Jisheng decoction intervening bone destruction in patients with RA by regulating expressions of inflammatory factors. Acta Chin Med Pharmacol (Zhongyi Yao Xuebao). 2021; 49 (1): 44- 48 (in Chinese).

[62]

Tseng SH , Lee CJ , Chen SH , et al. Cinnamic aldehyde, an anti- inflammatory component in Du-Huo-Ji-Sheng-Tang, ameliorates arthritis in II collagenase and monosodium iodoacetate induced osteoarthritis rat models. J Tradit Complement Med. 2023; 13 (1): 51- 61.

[63]

Wang JY , Chen WM , Wen CS , Hung SC , Chen PW , Chiu JH . Du-Huo-Ji-Sheng-Tang and its active component Ligusticum chuanxiong promote osteogenic differentiation and decrease the aging process of human mesenchymal stem cells. J Ethnopharmacol. 2017; 198: 64- 72.

[64]

Jiao SD , Du F . Diagnosis and treatment of Wang-Bi. J Tradit Chin Med. 1992 (3): 11- 13 (in Chinese).

[65]

Jiao SD . Further discussion on the diagnosis and treatment of Wang-Bi. J Tradit Chin Med. 1997 (8): 504- 505 (in Chinese).

[66]

Feng JP , Kang SW , Shang LQ , Shan HZ , Tai DX . Research progress on the mechanism of Drynaria fortunei and Himalayan Teasel Root in knee osteoarthritis. J Practical Tradit Chin Intern Med (Shiyong Zhongyi Neike Zazhi). 2025 (in Chinese).

[67]

Li X , Han YQ , Zhang XQ , Xu J , Wang CF . Compatibility rule of Biqi Capsule in treatment of rheumatoid arthritis based on network pharmacology. Chin Tradit Herb Drugs. 2023; 54 (23): 7607- 7617 (in Chinese).

[68]

Lin LJ . Observations on the efficacy of medicinal insects in the treatment of recalcitrant rheumatoid arthritis. J New Chin Med (Xin Zhongyi). 2016; 48 (7): 117- 119 (in Chinese).

[69]

Lu SW , Li SW . Progress in the study of the mechanism of action of medicinal insects in the treatment of rheumatoid arthritis. Shanxi J Tradit Chin Med (Shanxi Zhongyi). 2024; 45 (3): 427- 429 (in Chinese).

[70]

Yao CH , Xu CQ , Zhang YQ , Yan ZR , Wang JP . Clinical observation on delaying progression of bone erosion in rheumatoid arthritis with Bushen Zhiwang decoction. J Basic Chin Med (Zhongguo Zhongyi Jichu Yixue Zazhi). 2023; 29 (6): 976- 981 (in Chinese).

[71]

Lan TY , Wang ZH , Yan ZR , Yao CH , Yu HW . The delaying effect of Bushen Zhiwang decoction on bone destruction in rheumatoid arthritis patients with a pattern of deficiency of both liver and kidney based on modified total Sharp score. J Beijing Univ Tradit Chin Med (Beijing Zhongyi Yao Daxue Xuebao). 2023; 46 (4): 557- 563 (in Chinese).

[72]

Ma R . Study on the mechanism of anti-inflammatory and anti- bone-destroying effects of Zhiwang decoction on rats with collagen-induced arthritis. Beijing University of Chinese Medicine; 2021 (in Chinese).

[73]

Yin XT , Zhao SC , Lu QP , Zhu XM , Xu J . Research progress of Wang Bi preparations in the treatment of rheumatoid arthritis. Hebei Med J (Hebei Yiyao). 2024; 46 (24): 3806- 3811 (in Chinese).

[74]

Ma YC , Lyu L , Wang HL . Mechanism research progress of Leigongteng (Tripterygium wilfordii) and its extracts treating rheumatoid arthritis by regulating related signaling pathway. Acta Chin Med. 2025 (in Chinese).

[75]

Wu ZQ , Gong BF , Wang JC , Peng HY . Mechanism of Caulis sinomenii in treating rheumatoid arthritis based on network pharmacology and molecular docking. J Jishou Univ (Nat Sci Ed). 2024; 45 (6): 44- 53 (in Chinese).

[76]

Zhao XR , Wang HF , Liu Y , Huo XP , Liang DY . Effect of total glucosides of peony on the proliferation, differentiation, and mineralization of MC3T3-E1 osteoblastic cells. Chin J Integr Tradit West Med. 2019; 39 (10): 1230- 1233 (in Chinese).

[77]

Li H , Cao XY , Dang WZ , Jiang B , Zou J , Shen XY . Total glucosides of Paeony protects against collagen-induced mouse arthritis via inhibiting follicular helper T cell differentiation. Phytomedicine. 2019; 65: 153091.

[78]

Wang ZY . Clinical observation of Guishao Zhimu Jiateng decoction combined with Tofacitinib Citrate in the treatment of rheumatoid arthritis. Nanjing University of Chinese Medicine; 2021 (in Chinese).

[79]

Shang CY , Yi GX , Gan JP , Dai M , Li YP . Efficacy of Tiaobi decoction in treating rheumatoid arthritis of Qi and blood deficiency and its effect on TNF-α and IL-6. Acta Chin Med (Zhongyi Xuebao). 2023; 38 (5): 1068- 1073 (in Chinese).

[80]

Zhang YQ , Wen J , Li YN , et al. Visual analysis of the acupoint prescription characteristics of acupuncture and moxibustion in treatment of rheumatoid arthritis. Chin Acupunct Moxibustion. 2022; 42 (11): 1311- 1316 (in Chinese).

[81]

Wang YY , Xu Y , Yuan GM , et al. Research status of rheumatoid arthritis bone destruction and acupuncture intervention mechanism based on osteoimmunology. Shandong J Tradit Chin Med. 2022; 41 (3): 343- 347 (in Chinese).

[82]

Huang WL , Yang F . Overview of external Chinese medicine treatment for rheumatoid arthritis. Hunan J Tradit Chin Med (Hunan Zhongyi Zazhi). 2022; 38 (1): 174- 177 (in Chinese).

[83]

Lin XH . Clinical observation on 44 cases with rheumatoid arthritis treated by fumigation and steaming of Chinese herbal as adjuvant therapy. J Gansu Univ of Chin Med (Gansu Zhongyi Yao Daxue Xuebao). 2017; 34 (5): 44- 47 (in Chinese).

[84]

Zhang SY , Hao LH , Cao J , Lai LQ , Zeng K . Research progress on clinical application and action mechanism of traditional Chinese medicine hot pack therapy. Clin J Trad Chin Med (Zhongyi Yao Linchuang Zazhi). 2022; 34 (10): 1989- 1993 (in Chinese).

[85]

Zhao JY , Chen LM , Guo SJ , Li XL , Bai J . Research progress on external treatment of knee osteoarthritis with traditional Chinese medicine. Chin Med Herald (Zhongguo Yiyao Daobao). 2021; 18 (26): 43- 45+64 (in Chinese).

[86]

Meng J , Liu SS , Wang Y . Therapeutic efficacy of combination of acupuncture and Du-Huo-Ji-Sheng-Tang-Jia-Jian in the treatment of rheumatoid arthritis with deficiency of liver and kidney. Mod J Integrated Tradit Chin West Med (Xiandai Zhongxi Yi Jiehe Zazhi). 2024; 33 (5): 680- 684 (in Chinese).

[87]

An XB , Liu JZ , Fu SL , Zhang L , Gao Y . Clinical observation of Diteng Bitong granules combined with Chinese medicine fumigation in the treatment of rheumatoid arthritis (cold arthritis). World J Integrated Tradit West Med (Shijie Zhongxi Yi Jiehe Zazhi). 2020; 15 (4): 670- 673 (in Chinese).

[88]

Li XR , Liu QH . Clinical observation on 30 cases of rheumatoid arthritis with deficiency of liver and kidney treated by combining methotrexate with Du-Huo-Ji-Sheng-Tang-Jia-Wei. J Gansu Univ Chin Med (Gansu Zhongyi Yao Daxue Xuebao). 2017; 34 (6): 56- 59 (in Chinese).

[89]

Zhang EZ . Effects of leflunomide combined with tripterygium glycosides on inflammatory indexes and bone repair indexes in patients with rheumatoid arthritis. Heilongjiang Med Pharm (Heilong Jiang Yiyao Kexue). 2022; 45 (4): 191- 192 (in Chinese).

[90]

Liang QQ , Mao JC , Xiao LB , Xu H . Expert consensus on the diagnosis and treatment of rheumatoid arthritis with integrated traditional Chinese and Western. Med World Chin Med (Shijie Zhongyi Yao). 2023; 18 (7): 923- 928935 (in Chinese).

[91]

Yang L . An overview of possible interactions between Chinese and Western medicines. Evaluation Analysis Drug-Use Hospitals Chin (Zhongguo Yiyuan Yongyao Pingjia Yu Fenxi). 2013; 13 (9): 774- 777 (in Chinese).

[92]

Chong R , Shi HH , Cheng G , Zou MJ . Drug interaction of ginkgo biloba extract. J Shenyang Pharm Univ. 2014; 31 (3): 217- 223 (in Chinese).

[93]

Luo H , Zhang X , Feng YR , Zhao Y , Yang JL . Efficacy of combination of traditional Chinese and Western medicine in treatment of rheumatoid arthritis of damp-heat blocking collateral type. World J Integrated Tradit West Med (Shijie Zhongxi Yi Jiehe Zazhi). 2022; 17 (11): 2273- 2277 (in Chinese).

[94]

Qi WX . Effect of Bushen Tongluo decoction combined with western medicine on bone destruction and bone metabolic markers in rheumatoid arthritis. Gansu University of Chinese Medicine; 2022 (in Chinese).

[95]

Zhang R , Tang XP , Wang J , et al. The impact of traditional Chinese Medicine QingreHuoxue treatment and the combination of methotrexate and hydroxychloroquine on the radiological progression of active rheumatoid arthritis:a 52-week follow-up of a randomized controlled clinical study. Evid Base Compl Alternative Med. 2022; 2022: 5808400- 5808412.

[96]

Liu ZR . Clinical curative effect observation of Angelica Nian Tong decoction combined with Western medicine on damp-heat type of active rheumatoid arthritis in patients. Gansu University of Chinese Medicine; 2020 (in Chinese).

[97]

Hu F . Short-term and long-term effects of applying traditional Chinese medicine syndrome differentiation combined with methotrexate in the treatment of rheumatoid arthritis. J Sichuan Tradit Chin Med (Sichuan Zhongyi). 2018; 36 (2): 76- 79 (in Chinese).

[98]

Li Y , Liu J , Hu Y , Cong C , Chen Y , Wang F . Comprehensive review of patients with hypercoagulable state in rheumatoid arthritis and strategies to reduce readmission rates:a retrospective cohort study based on protective exploration of traditional Chinese medicine. Medicine. 2024; 103 (50): e40890.

[99]

Lou X , Zhou Q , Dong Z , Bai L , Su J , Yue H . Innovative strategies for bone organoid:synergistic application and exploration of advanced technologies. J Orthop Translat. 2025; 54: 180- 198.

[100]

Jin X , Huang L , Wang X , et al. Synovial organoids:from fundamental construction to groundbreaking applications in arthritic disorders. J Orthop Translat. 2025; 54: 26- 36.

[101]

Lin X , Lin T , Wang X , et al. Sesamol serves as a p53 stabilizer to relieve rheumatoid arthritis progression and inhibits the growth of synovial organoids. Phytomedicine. 2023; 121: 155109.

[102]

Abebaw D , Akelew Y , Adugna A , et al. Extracellular vesicles:immunomodulation, diagnosis, and promising therapeutic roles for rheumatoid arthritis. Front Immunol. 2024; 15: 1499929.

[103]

Matwiejuk M , Mikłosz A , Myśliwiec H , Chabowski A , Flisiak I . The therapeutic efficacy of mesenchymal stem cells and their extracellular vesicles in the treatment of diverse skin diseases. Front Immunol. 2025; 16: 161626066.

[104]

Jouybari MT , Mojtahedi F , Babaahmadi M , Faeed M , Eslaminejad MB , Taghiyar L . Correction:advancements in extracellular vesicle targeted therapies for rheumatoid arthritis:insights into cellular origins, current perspectives, and emerging challenges. Stem Cell Res Ther. 2024; 15 (1): 405.

[105]

Chen J , Tan J , Wang N , et al. Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis- induced joint damage in inflammatory arthritis. Cell Rep Med. 2025; 6 (4): 102046.

[106]

Xiao YT , Xue L , Zhu CY , Piao XM . Effect of Yi qi Qing luo Formula on inflammation and bone destruction in patients with rheumatoid arthritis. Academic J Shanghai Univ Traditi Chin Med (Shanghai Zhongyi Yao Daxue Xuebao). 2022; 36 (4): 19- 25 (in Chinese).

[107]

Wan KW , Zhao YL , Li N , Li H , Yan W . Progress of Chinese medicine intervention in rheumatoid arthritis-related signalling pathways. Yunnan J Tradit Chin Med Materia Medica (Yunnan Zhongyi Zhongyao Zazhi). 2025; 46 (1): 83- 89 (in Chinese).

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