Development of the composition and technology of effervescent tablets for the prevention of cerebral circulation disorders in the elderly

Abstract

Increasing the level of antioxidants in the human body plays an important role in increasing longevity. Studies on small laboratory animals showed that in the main group with an increased content of antioxidant enzymes, life expectancy was 20% higher than in the comparison group with age and heart diseases. Thus, the hypothesis is confirmed that a high content of active free radical molecules causes aging and the data obtained on small laboratory animals will increase the human lifespan. This fact is associated with the occurrence of heart and oncological diseases, as well as other age-related pathologies. In order to prevent the development of the above diseases, a drug was developed with an innovative composition of complex-compatible components. The experimental drug contains substances with an increased content of antioxidants for the prevention of cerebrovascular accidents, such as dihydroquercetin and black grape extract. And also vitamins and amino acids: succinic acid, ascorbic acid, glycine. The choice of the composition of the experimental drug was carried out on the basis of the antioxidant properties of these groups of substances, which are widely known, and their combined use will become a potentiated synergy of the selected components and complement their effect. Due to the fact that the classical technology for the production of effervescent dosage forms does not allow combining the components of the composition of the experimental drug, the task of developing an individual technology for combining the acid and alkaline fractions of the formulation by separating the components at the stage of the technological process of drying the raw material was solved. Thanks to this, it became possible to separate the granulation of acid and alkaline components, which made it possible to stabilize the tabletting mixture (3 tables, bibliography: 8 refs.).

Keywords

dihydroquercetin / formulation development / granulation method / hygroscopicity / pharmaceutical compatibility / polyethylene glycol / production technology / separate granulation

References

[1] Shevchenko AM. Methodological aspects of the development of technology of solid instant dosage forms. Abstract of D.Sc. (Pharmaceutical) thesis. Moscow; 2009. 42 p. (In Russ.)

[2] Шевченко А.М. Методологические аспекты разработки технологии твердых быстрорастворимых лекарственных форм. Автореф. … докт. фарм. наук. М.: 2009. 42 с.

[3] Blinov DV, Akarachkova ES, Orlova AS, Kryukov EV, Korabelnikov DI. A new concept for the development of clinical recommendations in Russia. Pharmacoeconomics. Modern pharmacoeconomics and pharmacoepidemiology. 2019;12(2):125–144. (In Russ.)

[4] Блинов Д.В., Акарачкова Е.С., Орлова А.С., Крюков Е.В., Корабельников Д.И. Новая концепция разработки клинических рекомендаций в России // Фармакоэкономика. Современная фармакоэкономика и фармакоэпидемиология. 2019. Т. 12, № 2. С. 125–144.

[5] Moroz EV, Karateev AE, Kryukov EV, Chernetsov VA. Gastrointestinal bleeding when using new oral anticoagulants: epidemiology, risk factors, treatment and prevention. Scientific and practical rheumatology. 2017;55(6):675–684. (In Russ.)

[6] Мороз Е.В., Каратеев А.Е., Крюков Е.В., Чернецов В.А. Желудочно-кишечные кровотечения при использовании новых пероральных антикоагулянтов: эпидемиология, факторы риска, лечение и профилактика // Научно-практическая ревматология. 2017. Т. 55, № 6. С. 675–684.

[7] Zhukova AG, Kazitskaya AS, Zhdanova NN, et al. The role of dihydroquercetin in the molecular mechanisms of myocardial protection in dust pathology. Labor medicine and industrial ecology. 2020;60(3):178–183. (In Russ.)

[8] Жукова А.Г., Казицкая А.С., Жданова Н.Н., и др. Роль дигидрокверцетина в молекулярных механизмах защиты миокарда при пылевой патологии // Медицина труда и промышленная экология. 2020. Т. 60, № 3. С. 178–183.

[9] Shevchenko AM. To assess the gas-forming properties of effervescent tablets. Materialy 58-y mezhregional’noy konferentsii po farmatsii i farmakologii (Materials of the 58th Interregional Conference on Pharmacy and Pharmacology). Pyatigorsk. 2003. P. 172–175. (In Russ.)

[10] Шевченко А.М. К оценке газообразующих свойств шипучих таблеток // Материалы 58-й межрегиональной конференции по фармации и фармакологии. Пятигорск, 2003. С. 172–175.

[11] Kryukov E. V. Changes in lipid peroxidation and hemostasis in military personnel in the process of adaptation to military service. Military Medical Journal. 2003;324(11):72–73. (In Russ.)

[12] Крюков Е.В. Изменения перекисного окисления липидов и гемостаза у военнослужащих в процессе адаптации к военной службе // Военно-медицинский журнал. 2003. Т. 324, № 11. С. 72–73.

[13] Shevchenko AM. To the question of the technological quality of effervescent tablets. Vestnik VSU. Series: Chemistry. Biology. Pharmacy. 2006;(2):415. (In Russ.)

[14] Шевченко А.М. К вопросу о технологическом качестве шипучих таблеток // Вестник ВГУ. Сер. Химия. Биология. Фармация. 2006. № 2. С. 415.

[15] Kazimirko VK. The antioxidant system and its functioning in the human body. Healthy Ukraine. 2004;(98):11–18. (In Russ.)

[16] Казимирко В.К. Антиоксидантная система и ее функционирование в организме человека // Здоровая Украина. 2004. № 98. С. 11–18.

RIGHTS & PERMISSIONS

Listov K.N., Yakovlev R.A.