Pathology of microstructural brain connectivity in paranoid schizophrenia (according to diffusion-tensor tractography data)

Abstract

AIM: revealing microstructural brain connectivity alterations in patients with paranoid schizophrenia.

MATERIALS AND METHODS: 25 patients diagnosed with paranoid schizophrenia were examined. The control group was 30 healthy people without neurological and somatic diseases. Studies were carried out on the Philips Ingenia magnetic resonance tomograph, with a magnetic field strength of 1.5 T using the DTI pulse sequence. Data processing was carried out using the tractographic module “DSI Studio”.

RESULTS: According to the group assessment of the obtained tractographic brain data, significant differences in microstructural connectivity in the group of patients with paranoid schizophrenia were detected. A pathological conglomerate of cortical-subcortical structure connectivity was found, different from the sets of normal connections in the control group, consisting of a cingulate gyrus, hippocampus and thalamus. Such a pathological control center is one of the possible tractographic patterns of schizophrenia. In our opinion, the pathological connectivity of the hippocampus and thalamus, as one of the main components of the limbic system of the brain, reduces the controlling emotional function of the cingulate cortex, the control center of this system. In this case, excessive connectivity of the hippocampus with the cingulate cortex may indicate an incorrect implementation of their interaction, which also affects the occurrence or progression of emotional-will disorders. The thalamus, being the center of transmission of sensory and motor information from the sensory organs, can transmit incorrect redundant data about what is happening around the body and participate in the formation of auditory and visual hallucinations. Also, the pathological work of the thalamus may be involved in the progression of autism. Thus, the patient is increasingly losing touch with reality, increasingly preferring unknowingly fantasy, erasing ties with reality. Data from one of the characteristics of the artiformal neural network – the clustering coefficient – were significantly increased in patients compared to the control group, which may indicate the presence of excess, abnormal microstructural connectivity in the network.

CONCLUSION: The study confirms the presence of microstructural and neural network changes in the hippocampus, thalamus, cingulate cortex and basal ganglia. These changes are peculiar tractographic semiotic signs of brain pathology in paranoid schizophrenia. This study is a step in the search for a tool to identify the features of neuroplasticity disorders in this disease and schizophrenia screening (2 figures, 3 tables, bibliography: 13 refs).

Keywords

limbic system / microstructural connectivity / neural network / paranoid schizophrenia / rich-club / tractography

References

[1] Aleksandrovsky YuA, Neznanov NG, editors. Psychiatry: a national guide. Moscow: GEOTAR-Media Publisher; 2018. 1008 p. (In Russ.)

[2] Психиатрия: национальное руководство / под ред. Ю.А. Александровского, Н.Г. Незнанова. М.: ГЭОТАР-Медиа, 2018. 1008 с.

[3] Shamray VK, Kurasov ES, Nechiporenko VV. Possibilities of using Mexidol in comprehensive therapy of mental disorders. Neuroscience and Behavioral Physiology. 2020;120(5):160–164. (In Russ.) DOI: 10.17116/jnevro2020120051160

[4] Шамрей В.К., Курасов Е.С., Нечипоренко В.В. Возможности применения Мексидола в комплексной терапии психических расстройств // Журнал неврологии и психиатрии имени C.C. Корсакова. 2020. Т. 120, № 5. С. 160–164. DOI: 10.17116/jnevro2020120051160

[5] Tarumov DA, Trufanov AG, Zheleznyak IS, et al. Abnormalities in microstructural brain connectivity in patients with opioid or alcohol dependence. Doktor.Ru. 2020;19(4):35–42. (In Russ.) DOI: 10.31550/1727-2378-2020-19-4-35-42

[6] Тарумов Д.А., Труфанов А.Г., Железняк И.С., и др. Патология микроструктурной коннективности головного мозга при синдроме зависимости от опиоидов и алкоголя // Доктор.Ру. 2020. Т. 19, № 4. С. 35–42. DOI: 10.31550/1727-2378-2020-19-4-35-42

[7] Mwansisya T. Task and resting-state fMRI studies in first-episode schizophrenia: A systematic review. Schizophr Res. 2017;(189):9–18. DOI: 10.1016/j.schres.2017.02.026

[8] Mwansisya T. Task and resting-state fMRI studies in first-episode schizophrenia: A systematic review // Schizophr. Res. 2017. No. 189. P. 9–18. DOI: 10.1016/j.schres.2017.02.026

[9] Deng Y. Tractography-based classification in distinguishing patients with first-episode schizophrenia from healthy individuals. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019;(88):66–73. DOI: 10.1016/j.pnpbp.2018.06.010

[10] Deng Y. Tractography-based classification in distinguishing patients with first-episode schizophrenia from healthy individuals // Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2019. No. 88. P. 66–73. DOI: 10.1016/j.pnpbp.2018.06.010

[11] Gómez-Gastiasoro A. Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study. Neuroimage Clin. 2019;(22):101781. DOI: 10.1016/j.nicl.2019.101781

[12] Gómez-Gastiasoro A. Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study // Neuroimage Clin. 2019. No. 22. 101781. DOI: 10.1016/j.nicl.2019.101781

[13] Ji E. Increased and Decreased Superficial White Matter Structural Connectivity in Schizophrenia and Bipolar Disorder. Schizophr Bull. 2019;45(6):1367–1378. DOI: 10.1093/schbul/sbz015

[14] Ji E. Increased and Decreased Superficial White Matter Structural Connectivity in Schizophrenia and Bipolar Disorder // Schizophr. Bull. 2019. Vol. 45, No. 6. P. 1367–1378. DOI: 10.1093/schbul/sbz015

[15] Seitz J. Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia. Schizophr Bull. 2016;42(3):762–771. DOI: 10.1093/schbul/ sbv171

[16] Seitz J. Tractography Analysis of 5 White Matter Bundles and Their Clinical and Cognitive Correlates in Early-Course Schizophrenia // Schizophr. Bull. 2016. Vol. 42, No. 3. P. 762–771. DOI: 10.1093/schbul/sbv171

[17] Shon S, Yoon W, Kim H, et al. Deterioration in Global Organization of Structural Brain Networks in Schizophrenia: A Diffusion MRI Tractography Study. Front Psychiatry. 2018;(9):272. DOI: 10.3389/fpsyt.2018.00272

[18] Shon S., Yoon W., Kim H., et al. Deterioration in Global Organization of Structural Brain Networks in Schizophrenia: A Diffusion MRI Tractography Study // Front. Psychiatry. 2018. No. 9. P. 272. DOI: 10.3389/fpsyt.2018.00272

[19] Zvartau EE, Patkina NA. Motivational components and self-stimulation in behavioral responses caused by electrical stimulation of the cat hypothalamus. Zhurnal vysshei nervnoi deyatelnosti imeni I.P. Pavlova. 1974;24(3):529. (In Russ.)

[20] Звартау Э.Э., Паткина Н.А. Мотивационные компоненты и самостимуляция при поведенческих реакциях, вызванных электрической стимуляцией гипоталамуса кошек // Журнал высшей нервной деятельности им. И.П. Павлова 1974. Т. 24, № 3. С. 529.

[21] Tarumov DA. Magnetic resonance diagnostics of morphofunctional brain changes in mental and behavioral disorders caused by opioid and alcohol use [dissertation]. Saint Petersburg; 2019. (In Russ.)

[22] Тарумов Д.А. Магнитно-резонансная диагностика морфофункциональных изменений головного мозга при психических и поведенческих расстройствах, вызванных употреблением опиоидов и алкоголя. Автореф. дис. … д-ра мед. наук. СПб., 2019.

[23] Paré D, Collins D, Pelletier J. Amygdala oscillations and the consolidation of emotional memories. Trends Cogn Sci. 2002;6(7): 306–314. DOI: 10.1016/s1364-6613(02)01924-1

[24] Paré D., Collins D., Pelletier J. Amygdala oscillations and the consolidation of emotional memories // Trends Cogn. Sci. 2002. Vol. 6, No. 7. P. 306–314. DOI: 10.1016/s1364-6613(02)01924-1

[25] Khadka S. Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study. Biol Psychiatry. 2013;74(6):458–466. DOI: 10.1016/j.biopsych.2013.04.024

[26] Khadka S. Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study // Biol. Psychiatry. 2013. Vol. 74, No. 6. P. 458–466. DOI: 10.1016/j.biopsych.2013.04.024

RIGHTS & PERMISSIONS

Puchkov N.A., Tarumov D.A., Markin K.V., Prochik Y.E., Tyomniy A.V., Maslov V.E.