DEPENDENCE OF THE METASTATIC POTENTIAL OF A CANCER ON THE DEPTH OF ITS GERMINATION AND LOCAL- IZATION IN COLON CANCER

Abstract

Nowadays, despite the success of medicine in the diagnosis and treatment of cancer, it remains one of the most common causes of death. One of the most common and dangerous neoplasms is colon cancer (1 million cases annually in the world). Moreover, out of a million, about 600 thousand die in the first year. Clinical cases of colorectal cancer in world practice are characterized by the difficulty of its diagnosis, complicating the appointment of timely treatment, as well as predicting the dynamics of the disease associated with tumor metastasis. At the same time, carcinoma is detected late, because in hollow organs, such as the colon, it does not manifest itself in any way until the stages of the tumor process T3, T4, when the symptoms are intestinal bleeding and obstruction. The aim of the study was to establish the dependence of the metastatic potential on the depth of tumor invasion and localization. Methods used: analysis and synthesis, statistics. A direct relationship was established between the metastatic potential of a colorectal cancer tumor and the depth of its invasion into the intestinal wall (at the stage of the T4 tumor process, metastases spread in 35.7% of cases, and at T3 in 28.5%, respectively). An examination of the protocols revealed the pattern of the predominant distribution of distant metastases to certain organs (liver, mesentery, kidneys) depending on the location of the primary tumor (when the tumor is located in the sigmoid colon, the descending part of the colon, metastasis occurs in the liver (57%), in the kidney (20 %), when located in the cecum - into the soft tissues and organs of the small pelvis (20%).

Keywords

colon cancer / distant metastases / invasion depth / localization / prognosis

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RIGHTS & PERMISSIONS

Likhodkin V.A., Saveliev G.N.