REACTIVE CHANGES OF LIVER TISSUES AT PATHOLOGICAL CONDITIONS

Abstract

A morphometric analysis of histological preparations of the human liver was carried out at the optical level. It was found that in the early stages of diagnosed diseases, such as fatty degeneration and hepatitis, reactive changes affect histologically different cellular liver differs. The parenchyma cells, the hepatocytes, the leading cellular organ differential, are subject to the greatest changes. They observed vacuolization of the cytoplasm, probably caused by increased glycogen synthesis, an increase in the number of peroxisomes, lysosomes, and endoplasmic reticulum hypertrophy, which presumably refers to the compensatory-adaptive mechanisms of the organ. Along with hepatocytes, Kupffer cells, endothelial cells of the sinusoidal capillaries, hepatic stellate cells (Ito cells), lymphocytes, etc. are isolated in the hepatic lobules. Interaction of hepatocytes and non-parenchymal cells through paracrine factors forming the liver microenvironment is important both in normal and pathological conditions. The number of Kupffer cells, macrophages of the liver, with fatty degeneration and hepatitis increases. Reactive changes in tissue components of blood vessels and bile ducts are less expressive.

Keywords

hepatocyte / triad of the liver / Kupffer cells / fatty degeneration / hepatitis / vacuolization of the cytoplasm / reactive changes in cells

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Gorbulich V.A.