Characteristics of the metabolic profile and the state of the vascular wall in men with metabolically neutral obesity

Abstract

BACKGROUND: The prevalence of overweight in the Russian population is increasing every year. A diet with an excessive amount of easily digestible carbohydrates, low physical activity contribute to the rapid development of obesity at a young age. In Russia, 26% of the male population and 30% of women are overweight. When examining obese patients, the adipokine activity of adipose tissue is not taken into account in daily medical activities. The current concept of metabolically healthy obesity causes certain discussions in the scientific community due to diagnostic difficulties in stratifying overweight patients into metabolically “healthy” and “unhealthy”.

AIM: was to characterize the lipid and carbohydrate profile, as well as to evaluate changes in the vascular wall in men with metabolically neutral obesity after a 3–4-year curation period.

MATERIALS AND METHODS: The hospital therapy clinic analyzed the case histories of 93 patients aged 30 to 45 years. The study group of patients was examined twice: initially and 3–4-years after the initial examination. An anthropometric profile was examined in the designated sample of patients, a study of biochemical blood analysis was performed, and an assessment of the cardiovascular system was carried out.

RESULTS: of the study showed that the metabolically neutral type is characterized by a low frequency of metabolic profile disorders, as well as parameters of the cardiovascular system.

CONCLUSIONS: The probability of developing new cases of prediabetes, type 2 diabetes mellitus and initial atherosclerosis is maximal in patients with previously diagnosed insulin resistance and metabolically healthy obesity, minimal — with normal body weight and in patients with metabolically neutral obesity.

Keywords

diabetes mellitus / leptin / metabolic syndrome / metabolically healthy obesity / metabolically neutral obesity / prediabetes / subclinical atherosclerosis

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RIGHTS & PERMISSIONS

Sokolov D.A., Serdyukov D.Y.