Influence of intestinal dysbacteriosis on the course of pregnancy

Abstract

BACKGROUND: Due to the active development of molecular genetic diagnostic techniques, much attention is now being paid to the study of intestinal microflora. A number of studies have demonstrated the major influence of the intestinal microbiota on the course of pregnancy. However, the number of publications devoted to this problem is limited.

AIM: The aim of the investigation is to assess the qualitative and quantitative composition of the intestinal microflora in pregnant women.

MATERIALS AND METHODS: To achieve this goal, 200 pregnant women in the age group 18 to 43 years and with a gestational age of 6 to 22 weeks were examined. A quantitative and qualitative analysis of the microbiocenosis of the vagina and rectum was performed using the real-time polymerase chain reaction method.

RESULTS: The results of the study demonstrated the presence of intestinal dysbacteriosis in 100% of pregnant women. Grade I dysbacteriosis was diagnosed in 64.5% of cases, grade II in 26.5% and grade III in 9%. In patients with moderate to severe dysbacteriosis, opportunistic pathogens Enterobacter spp., Clostridium difficile, Campylobacter spp. and Streptococcus spp. in concentrations exceeding formally permissible values. High quantitative indicators of clinically significant opportunistic pathogens in the vaginal biotope were detected amid the decrease in normal flora and a high concentration of opportunistic pathogens in the intestinal biocenosis. Grade II and III intestinal dysbiosis should be considered as a risk factor for the formation of a complicated course of the gestational period in the early stages.

CONCLUSIONS: Thus, pregnancy is a predisposing factor to the formation of dysbiotic changes in the intestine. In turn, rational management of intestinal dysbacteriosis can contribute to the correct course of the gestational period in the early stages.

Keywords

intestinal dysbacteriosis / intestinal microbiota / methods of molecular genetic diagnostics / vaginal microbiocenosis / pregnancy failure / pregnancy / vaginal dysbiosis / microflora disorder

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