Interactomics and personalized pharmacotherapy – present and looking to the future

Abstract

The review highlights the advances in natural science that form the basis of the concept of personalized and precision medicine (PPM). The provisions of PPM (prediction, prevention, personalization) have been disclosed and modern molecular genetic tools have been shown, which are used in leading scientific and practical biomedical centers to improve the quality of treatment of patients with multifactorial diseases (MFD). The main principles of molecular genetic biomarking of MFDs, as well as gene technologies (CRISPR, non-coding RNA, etc.) used in medical practice and at the stage of clinical trials were highlighted. Particular attention has been paid to molecular genetic methods of targeted therapy for cancer, including antitumor vaccines. Scientific developments in the field of prediction and preventive treatment of MFD have been considered - precision healing technologies of tomorrow. The main provisions of interactomics as an interdisciplinary field of natural science have been highlighted, as well as the applied aspects of this section of fundamental science for the development of diagnostic and treatment-and-prophylactic technologies of a new generation.

Keywords

personalized and precision medicine / molecular genetic biomarkers / precision targeted therapy / medical interactomics

References

[1] Suchkov S. V., ed. Basics of Personalized and Precision Medicine. Textbook for students of medical universities and faculties. Kazan: MedDoc Mublishing House; 2021. 628 p. (In Russ.).

[2] Основы персонализированной и прецизионной медицины. Учебник для медицинских вузов и факультетов / под редакцией С. В. Сучкова. – Казань: ИД МедДок, 2021. – 628 с.

[3] Tykavin A. I., ed. Pathology: textbook. Moscow: INFRA-M; 2021. 844 p. (In Russ.).

[4] Патология: учебник / под редакцией А. И. Тюкавина. – Москва: ИНФРА-М, 2021. – 844 с.

[5] Filatova A. Yu., Sparber P. A., Krovisheeva I. A., et al. Long noncoding RNAs are a promising therapeutic target in various diseases. Vestnik RGMU = Bulletin of RSMU. 2017:(3);5-17. https://doi.org/10.24075/BRSMU.2017-03-01. (In Russ.).

[6] Филатова А. Ю. Длинные некодирующие РНК – перспективная мишень для терапии различных заболеваний / А. Ю. Филатова, П. А. Спарбер, И. А. Кривошеева [и др.] // ВЕСТНИК РГМУ. – 2017. – № 3. – С. 5–17. https://doi.org/10.24075/BRSMU.2017-03-01.

[7] Tyukavin A. I., Belostotskaya G. B., Zakharov Е. А., et al. Apoptotic Bodies of Cardiomyocytes and Fibroblasts – Regulators of Directed Differentiation of Heart Stem Cells. Bull Exp Biol Med. 2020;170(1):112-117. https://doi.org/10.1007/s10517-020-05015-0. (In Russ.).

[8] Tyukavin A. I., Belostotskaya G. B., Zakharov Е. А., et al. Apoptotic Bodies of Cardiomyocytes and Fibroblasts – Regulators of Directed Differentiation of Heart Stem Cells // Bull Exp Biol Med. 2020. Vol. 170, no. 1. P. 112-117. https://doi.org/10.1007/s10517-020-05015-0.

[9] Tsarev I. L., Melerzanov A. V. Review of approaches to immunotherapy in oncology. Issledovaniya i praktika v medicine = Research and Practical Medicine Journal. 2017;4(3):51-65. https://doi.org/10.17709/2409-2231-2017-4-3-5. (In Russ.).

[10] Царев И. Л. Обзор подходов к иммунотерапии в онкологии / И. Л. Царев, А. В. Мелерзанов // Исследования и практика в медицине. – 2017. – Т. 4. – № 3. – С. 51–65. https://doi.org/10.17709/2409-2231-2017-4-3-5.

[11] Goryaev A. A., Savkina M. V., Obukhov Yu. I., et al. DNA and RNA Vaccines: Current Status, Quality Requirements and Specific Aspects of Preclinical Studies. BIOpreparaty. Profilaktika, diagnostika, lechenie = BIOpreparations. Prevention, Diagnosis, Treatment. 2019;19(2):72-80. https://doi.org/10.30895/2221-996X-2019-19-2-72-80. (In Russ.).

[12] Горяев А. А. ДНК- и РНК-вакцины: современное состояние, требования к качеству и особенности проведения доклинических исследований / А. А. Горяев, М. В. Савкина, Ю. И. Обухов [и др.] // БИОпрепараты. Профилактика, диагностика, лечение. – 2019. – Т. 19. – № 2. – С. 72–80. https://doi.org/10.30895/2221-996X-2019-19-2-72-80.

RIGHTS & PERMISSIONS

Tyukavin A.I., Studneva M. ., Suchkov S.V.