Functional reserves and adaptive capabilities of the body in conditions of oxidative stress

Abstract

The review is devoted to the problem of forming functional reserves and increasing the adaptive capabilities of the human body to the action of negative factors of various nature, including those accompanied by violations of the antioxidant status. Functional reserves are determined by the metabolic and bioenergetic capabilities of the body, as well as the possibility of interaction of organs and body systems for self-regulation and optimization of its physiological functions. The levels of functional reserves determine the body’s ability to adapt urgently or long-term. Oxidative stress is a non–specific pathogenetic process that develops as a result of a sharp increase in oxidative (free radical, peroxide) processes with insufficient functioning of the endogenous antioxidant system of the body. Almost all pathological conditions are more or less accompanied by the development of oxidative stress, which determines the relevance and prospects of this study. Urgent and long-term compensatory mechanisms in oxidative stress are associated with the optimization of cellular energy supply and the state of the endogenous antioxidant system of the body, in which a special role belongs to the correction of mitochondrial disorders. Ensuring the functional capabilities of the body for urgent adaptation is possible using a complex of pharmacological preparations of multifunctional action based on antioxidants. Increasing the effectiveness of the formation of long-term adaptation is advisable due to the moderate and short-term effect of prooxidants on the body, for example, in widespread hypoxic training.

Keywords

functional reserves / adaptation / free radicals / peroxidation / antioxidants / mitochondrial dysfunction / oxidative stress / cellular energy supply / pharmacological preparations

References

[1] Dictionary of physiological terms (ed. by O. G. Gazenko). – Moscow: Nauka, 1987. – 446 p.

[2] Словарь физиологических терминов (отв. ред. О. Г. Газенко). – М.: Наука, 1987. – 446 с.

[3] Davidenko D. N. Functional reserves of adaptation of the human body // Social physiology: textbook. – 1996. – pp. 126–135.

[4] Давиденко Д. Н. Функциональные резервы адаптации организма человека // Социальная физиология: учебное пособие. – 1996. – С. 126–135.

[5] Kurzanov A. N., Zabolotskikh N. V., Manuilov A. M. Clinical and physiological aspects of the diagnosis of functional reserves of the body. // Kuban Scientific Medical Bulletin. – 2015. – № 6 (155). – Pp. 73–77.

[6] Курзанов А. Н., Заболотских Н. В., Мануйлов А. М. Клинико-физиологические аспекты диагностики функциональных резервов организма // Кубанский научный медицинский вестник. – 2015. – № 6 (155). – С. 73–77.

[7] Kurzanov A. N., Zabolotskikh N. V., Kovalev D. V. Functional reserves of the body: monograph / A. N. Kurzanov, N. V. Zabolotskikh, D. V. Kovalev – M.: Publishing House of the Academy of Natural Sciences, 2016. – 96 p.

[8] Курзанов А. Н., Заболотских Н. В., Ковалев Д. В. Функциональные резервы организма: монография / А. Н. Курзанов, Н. В. Заболотских, Д. В. Ковалев. – М.: Издательский дом Академии Естествознания, 2016. – 96 с.

[9] Ushakov I. B., Shalimov P. M. Functional reliability and functional reserves of the pilot // Bulletin of the Russian Academy of Medical Sciences. – 1996. – No. 7. – pp. 26–31.

[10] Ушаков И. Б., Шалимов П. М. Функциональная надежность и функциональные резервы летчика // Вестник РАМН. – 1996. – № 7. – С. 26–31.

[11] Kurzanov A. N. Functional reserves of the body in the perspective of clinical physiology // Modern problems of science and education. – 2015. – No. 4. – pp. 24–27.

[12] Курзанов А. Н. Функциональные резервы организма в ракурсе клинической физиологии // Современные проблемы науки и образования. – 2015. – № 4. – С. 24–27.

[13] Glazachev O. S. Kryzhanovskaya S.Yu. Adaptive medicine: a strategy for psychophysiological adaptation of a person to a critically altered environment // Bulletin of the International Academy of Sciences (Russian section). – 2019. – No. 1. – pp. 48–55.

[14] Глазачев О. С. Крыжановская С. Ю. Адаптационная медицина: стратегия психофизиологического приспособления человека к критически измененной окружающей среде // Вестник международной академии наук (русская секция). – 2019. – № 1. – С. 48–55.

[15] Hussain J., Cohen M. Clinical Effects of Regular Dry Sauna Bathing. // A Systematic Review. Evidence-Based Complementary and Alternative Medicine. –2018. – P. 37–49. (In Russ).

[16] Hussain J., Cohen M. Clinical Effects of Regular Dry Sauna Bathing // A Systematic Review. Evidence-Based Complementary and Alternative Medicine. –2018. – P. 37–49.

[17] Sosin D. V. Pharmacological correction of acute exogenous hypoxia with antihypoxants. / D. V. Sosin, A. V. Evseev, V. A. Pravditsev et al. / Bulletin of the Smolensk State Medical Academy. – 2015. – Vol. 14, No. 1. – pp. 46–71.

[18] Сосин Д. В. Фармакологическая коррекция острой экзогенной гипоксии антигипоксантами. / Д. В. Сосин, А. В. Евсеев, В. А. Правдицев и др. / Вестник Смоленской государственной медицинской академии. – 2015. – Т. 14, № 1. – С. 46–71.

[19] Verges S., Chacaroun S., Godin Ribuot D., Baillieul S. Hypoxic conditioning as a new therapeutic modality // Front. Pediatr. – 2015. – V. 3. – pp. 58–67. (In Russ).

[20] Verges S., Chacaroun S., Godin Ribuot D., Baillieul S. Hypoxic conditioning as a new therapeutic modality // Front. Pediatr. – 2015. – Vol. 3. – Р. 58–67.

[21] Churilova A. V., Glushchenko T. S., Vetrovoy O. V., Sarieva K. V., Rybnikova E. A., Tyulkova E. I., Samoilov M. O. Modification of histone acetylation by hypoxic postconditioning: the use of histone deacetylase inhibitors as a method of pharmacological correction of posthypoxic pathologies // Materials of the XXIII Congress of the I. P. Pavlov Physiological Society with international participation. – 2017. – pp. 676–678.

[22] Чурилова А. В., Глущенко Т. С., Ветровой О. В., Сариева К. В., Рыбникова Е. А., Тюлькова Е. И., Самойлов М. О. Модификация ацетилирования гистонов гипоксическим посткондиционированием: использование ингибиторов деацетилаз гистонов как способ фармакологической коррекции постгипоксических патологий // Материалы XXIII съезда Физиологического общества им. И. П. Павлова с международным участием. – 2017. – С. 676–678.

[23] Bouchama A., Aziz M. A., Mahri S. A., Gabere M. N., Dlamy M. A. et al. Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress // Scientific Reports. – 2017. – V. 7 – pp. 9429–9437. (In Russ).

[24] Bouchama A., Aziz M. A., Mahri S. A., Gabere M. N., Dlamy M. A. et al. Model of Exposure to Extreme Environmental Heat Uncovers the Human Transcriptome to Heat Stress // Sсientific Reports. – 2017. – Vol. 7 – Р. 9429–9437.

[25] Ran K., Xu H., Lu A. et al. Hypoxia preconditioning in the brain // Dev. Neurosci. – 2005. – V. 27. – P. 87–92. (In Russ).

[26] Ran K., Xu H., Lu A. et al. Hypoxia preconditioning in the brain // Dev. Neurosci. – 2005. – Vol. 27. – P. 87–92.

[27] Gening T. P., Ivanskaya H. H. Metabolic pathways of oxygen utilization and ATP production in liver tissue in acute circulatory hypoxia // Vestn. new medical technologies. – 2006. – T.XIII, No. 3. – pp. 32–34.

[28] Генинг Т. П., Иванская H. H. Метаболические пути утилизации кислорода и продукция АТФ в ткани печени при острой циркуляторной гипоксии // Вестн. новых мед. технологий. – 2006. – T.XIII, № 3. – С. 32–34.

[29] Dolgikh V. T., Larin A. I., Pilipchuk I. A. Metabolic disorders in critical conditions // Polytrauma. – 2007. – No. 3. – pp. 73–78.

[30] Долгих В. Т., Ларин А. И., Пилипчук И. А. Метаболические нарушения при критических состояниях // Политравма. – 2007. – № 3. – С. 73–78.

[31] Horowitz M. Epigenetics and cytoprotection with heat acclimation // J. Appl Physiol. – 2016. – V. 120. – P. 702–710. (In Russ).

[32] Horowitz M. Epigenetics and cytoprotection with heat acclimation // J. Appl Physiol. – 2016. – V. 120. – Р. 702–710.

[33] Hurtsilava O. G. Oxidative stress and inflammation: pathogenetic partnership: monograph / O. G. Hurtsilava, N. N. Pluzhnikov, Ya.A. Nakatis. – St. Petersburg: Publishing House of I. I. Mechnikov NWSMU, 2012. – 340 p.

[34] Хурцилава О. Г. Оксидативный стресс и воспаление: патогенетическое партнерство: монография / О. Г. Хурцилава, Н. Н. Плужников, Я. А. Накатис. – СПб.: Издательство СЗГМУ им. И. И. Мечникова, 2012. – 340 с.

RIGHTS & PERMISSIONS

Eco-Vector