The state of cancer care in Russia: pancreas cancer (C25). The survival rate of patients, taking into account the stage, localization and histological structure. Part II (clinical-population study)

Abstract

Pancreas cancer (С25) is a cancer with an unfavorable prognosis, remains one of the most lethal types of cancer, at the national level mortality exceeds morbidity. The analysis of patient survival at the population level on the scale of federal districts is not carried out in Russia with the exception of the North-West Federal District. Considering that the levels of standardized rates of morbidity and mortality from pancreas cancer are close in Russia and NWFD, and the value of index of accuracy practically coincide, the results of the population cancer registry (PCR) of the NWFD RF actually characterize the state of cancer care on average in Russia, with the exception of autonomous districts. The aim of the second stage of the study was to identify the true state of the effectiveness of the oncological service in Russia by calculating a key parameter – evaluating its performance, specifically, calculating the leading parameter – the survival rate of patients, taking into account the stage, localization, histological structure, and the possibility of curing patients The conducted research made it possible to determine the effectiveness of providing specialized oncological care to patients with pancreas cancer at the federal district level. An increase in the one–year observed survival rate for the period from 2000 to 2004 to 2015-2019 was established from 16.0 to 21.8% or by 36.3%, and five–year from 5.1 to 6.0%. The median survival rate did not reach 4 years. A significant difference in the levels of one-year survival of patients in different age groups has been established. Significant defects in the distribution of patients according to the stage of the disease were revealed. The specification of patient survival by detailed localization groups and major histotypes of tumors was studied.

Keywords

malignant tumors / pancreas cancer / survival of patients / localization structure / histological structure / treatment of patients

References

[1] Berrino F., Capocaccia R., Coleman M. P., Esteve J., Gatta G., Hakulinen T., Micheli M., Sant M., Verdecchia V., eds. Survival of cancer patients in Europe: the EUROCARE-2 study (IARC Scientific Publications No. 151). Lyon: International Agency for Research on Cancer, 1999.

[2] Berrino F., Capocaccia R., Esteve J., Gatta G., Hakulinen T., Micheli M., Sant M., Verdecchia V., eds. EUROCARE-3: the survival of cancer patients diagnosed in Europe during 1990–94. Ann Oncol 2003;14(Suppl. 5):pp1–155

[3] Berrino F., Capocaccia R., Esteve J., Gatta G., Hakulinen T., Micheli M., Sant M., Verdecchia V., eds. EUROCARE-3: the survival of cancer patients diagnosed in Europe during 1990–1994. Ann Oncol 2003;14(Suppl. 5):pp1–155

[4] Berrino F., Sant M., Verdecchia V., Capocaccia R., Hakulinen T., Estéve J., eds. Survival of cancer patients in Europe: the EUROCARE Study (IARC Scientific Publications No. 132). Lyon: International Agency for Research on Cancer, 1995.

[5] Capocaccia R., Gavin A., Hakulinen T., Lutz J. M., Sant M. (eds.) Survival of cancer patients in Europe, 1995–2002. The EUROCARE-4 study. Eur J Cancer 2009;45.

[6] Capocaccia R., Gavin A., Hakulinen T., Lutz J. M., Sant M. (eds.) Survival of cancer patients in Europe, 1995–2002. The EUROCARE-4 study. Eur J Cancer 2009; 45.

[7] De Angelis R., Sant M., Coleman M., Francisci S., Baili P., Pierannunzio D., Trama A., Visser O., Brenner H., Ardanaz E., Bielska-Lasota M., Engholm G., Nennecke A., Siesling S., Berrino F., Capocaccia R., and the EUROCARE-5 Working Group. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5 – a population-based study. Lancet Oncol 2014;15:23–34. doi: 10.1016/ S1470-2045(13)70546-1

[8] De Angelis R., Sant M., Coleman M., Francisci S., Baili P., Pierannunzio D., Trama A., Visser O., Brenner H., Ardanaz E., Bielska-Lasota M., Engholm G., Nennecke A., Siesling S., Berrino F., Capocaccia R., and the EUROCARE-5 Working Group. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5 – a population-based study. Lancet Oncol 2014; 15:23–34. doi: 10.1016/S1470-2045(13)70546-1

[9] Gatta G., Botta L., Rossi S., Aareleid T., Bielska-Lasota M., Clavel J., Dimitrova N., Jakab Z., Kaatsch P., Lacour B., Mallone S., Marcos-Gragera R., Minicozzi P., Sánchez-Pérez M. J., Sant M., Santaquilani M., Stiller C., Tavilla A., Trama A., Visser O., Peris-Bonet R.; EUROCARE Working Group. Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5—a population-based study. Lancet Oncol. 2014 Jan;15(1):35–47. doi: 10.1016/S1470-2045(13)70548-5.

[10] Gatta G., Botta L., Rossi S., Aareleid T., Bielska-Lasota M., Clavel J., Dimitrova N., Jakab Z., Kaatsch P., Lacour B., Mallone S., Marcos-Gragera R., Minicozzi P., Sánchez-Pérez M. J., Sant M., Santaquilani M., Stiller C., Tavilla A., Trama A., Visser O., Peris-Bonet R.; EUROCARE Working Group. Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5 – a population-based study. Lancet Oncol. 2014 Jan;15(1):35–47. doi: 10.1016/S1470-2045(13)70548-5.

[11] Malignant tumors in Russia in 2022 (morbidity and mortality) / Ed. A. D. Kaprina, V. V. Starinskogo, A. O. Shakhzadova, I. V. Lisichnikovoi. – M.: P. A. Herzen MSIOI – filial of NMRC of radiology Ministry of Public Health of the Russian Federation, 2023. – 275 p. (In Russ.)

[12] Злокачественные новообразования в России в 2022 году (заболеваемость и смертность) / под ред. А. Д. Каприна [и др.] М.: МНИОИ им. П. А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2023. – илл. – 275 с.

[13] Malignant tumors in Russia in 2023 (morbidity and mortality) / Ed. A. D. Kaprina, V. V. Starinskogo, A. O. Shakhzadova, I. V. Lisichnikovoi. – M.: P. A. Herzen MSIOI – filial of NMRC of radiology Ministry of Public Health of the Russian Federation, 2023. – 275 p. (In Russ.)

[14] Злокачественные новообразования в России в 2023 году (заболеваемость и смертность) / Под ред. А. Д. Каприна, В. В. Старинского, А. О.Шахзадовой – М.: МНИОИ им. П. А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, – 2024. – илл. – 252 с.

[15] Merabishvili V. M. Survival of cancer patients. St. Petersburg: KOSTA, 2011. – 330 p. (In Russ.)

[16] Мерабишвили В. М. Выживаемость онкологических больных. Выпуск второй. Часть I. – СПб.: КОСТА, 2011. – 330с.

[17] Merabishvili V. M. Survival of cancer patients. St. Petersburg: KOSTA, 2011. – 408 p. (In Russ.)

[18] Мерабишвили В. М. Выживаемость онкологических больных. Выпуск второй. Часть II. – СПб.: КОСТА, 2011. – 408с.

[19] Merabishvili V. M. Oncology statistic. Part I. Second edition, expanded – Saarbrücken, Deutschland (Germany): Lap Lambert Academic Publishing, 2015. – 223 p. (In Russ.)

[20] Мерабишвили В. М. Онкологическая статистика. Часть I. Второе издание, дополненное. – Saarbrücken, Deutschland (Германия): Lap Lambert Academic Publishing, 2015. – 221 с.

[21] Merabishvili V. M. Oncology statistic. Part II. Second edition, expanded – Saarbrücken, Deutschland (Germany): Lap Lambert Academic Publishing, 2015. – 247 p. (In Russ.)

[22] Мерабишвили В. М. Онкологическая статистика. Часть II. Второе издание, дополненное. – Saarbrücken, Deutschland (Германия): Lap Lambert Academic Publishing, 2015. – 247 c.

[23] Belfiori G., Crippa S., Falconi M. ASO Author Reflections: Long-Term Survivors after Upfront Resection for Pancreatic Cancer: Do They Really Exist? Ann Surg Oncol. 2021 Dec;28(13):8261–8262. doi: 10.1245/s10434-021-10402-6

[24] Belfiori G, Crippa S, Falconi M. ASO Author Reflections: Long-Term Survivors after Upfront Resection for Pancreatic Cancer: Do They Really Exist? Ann Surg Oncol. 2021 Dec;28(13):8261–8262. doi: 10.1245/s10434-021-10402-6

[25] Belfiori G, Crippa S, Francesca A, Pagnanelli M, Tamburrino D, Gasparini G, Partelli S, Andreasi V, Rubini C, Zamboni G, Falconi M. Long-Term Survivors after Upfront Resection for Pancreatic Ductal Adenocarcinoma: An Actual 5-Year Analysis of Disease-Specific and Post-Recurrence Survival. Ann Surg Oncol. 2021 Dec;28(13):8249–8260. doi: 10.1245/s10434-021-10401-7.

[26] Ettrich T. J. Seufferlein T. Systemic Therapy for Metastatic Pancreatic Cancer. Curr Treat Options Oncol. 2021 Oct 19;22(11):106. doi: 10.1007/s11864-021-00895-4.

[27] Sklyar D. A., Pavlovsky A. V., Polikarpov A. A., Popov S. A., Moiseenko V. E., Meshechkin A. V., Korytova L. I., Granov D. A. Results of complex treatment of patients with operable pancreatic head cancer using preoperative intra-arterial chemotherapy in combination with radiation therapy in multifractionation mode. Medical alphabet. 2021;(37):32–36. doi: 10.33667/2078–5631-2021-37-32-36. (In Russ.)

[28] Павловский А. В., Поликарпов А. А., Попов С. А. Результаты комплексного лечения больных операбельным раком головки поджелудочной железы с применением предоперационной внутриартериальной химиотерапии в сочетании с лучевой терапией в режиме мультифракционирования // Медицинский алфавит. 2021. – № .37. – C. 32–36 doi: 10.33667/2078-5631-2021-37-32-36

[29] Khanevich M. D., Perminova A. A., Manikhas G. M. The use of cryodestruction of pancreatic cancer when it is impossible to perform radical surgery. Bulletin of Pirogov National Medical & Surgical Center. 2023;18(4):36–38. doi: 10.25881/20728255_2023_18_4_36. (In Russ.)

[30] Ханевич М. Д., Перминова А. А., Манихас Г. М. Применение криодеструкции рака поджелудочной железы при невозможности произвести радикальное хирургическое вмешательство // Вестник Национального медико-хирургического Центра им. Н. И. Пирогова. – 2023. – Т. 18. – № 4. – С 36–38. doi: 10.25881/20728255_2023_18_4_36

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