Investigating the effects of Inonotus rickii extracts on the muscle contraction intensity

Kiran Ramchandra Ranadive; Neeta Vijayrao Jagtap; Pradnya Nilesh Jagtap; Ivan V. Zmitrovich; Vladimir V. Perelygin

doi:10.17816/phf63224

Pharmacy Formulas ›› 2021, Vol. 3 ›› Issue (1) :92 -96. DOI: 10.17816/phf63224

Biological sciences

research-article

Investigating the effects of Inonotus rickii extracts on the muscle contraction intensity

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Department of Botany, P.D.E.A.’s Annasaheb Magar Mahavidyalaya, Mahadevnagar

Department of Chemistry, P.D.E.A.’s Waghire College Saswad

Department of Pharmacology, P.D.E.A.’s SGRS College of Pharmacy, Saswad

Laboratory of Systematics and Geography of Fungi, Komarov Botanical Institute

Saint Petersburg State Chemical and Pharmaceutical University

M.Sc., Ph.D., Associate Professor, P.D.E.A.’s Annasaheb Magar Mahavidyalaya, Mahadevnagar

M. Sci. and M. Phil., Assistant Professor

M. Pharm., Assistant Professor, Department of Pharmacology, P.D.E.A.’s SGRS College of Pharmacy, Saswad, Taluka-Purandar

D.Sc. in Biology, Leading Researcher, Laboratory of Systematics and Geography of the Fungi, Komarov Botanical Institute RAS

Doctor of Medicine (MD), Professor, Head of the Industrial Ecology Department, Saint Petersburg State Chemical Pharmaceutical University

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Abstract

The aim of this study is to test the effect of aqueous, ethereal and alcoholic extracts of the fruit bodies of the wood-destroying fungus Inonotus rickii on locomotor activity resulting from contraction of both cross-striated and smooth muscles. The pharmacological activity of I. rickii raw materials was determined in vitro using the dose-response curve method (smooth muscles) and in experiments with oral intake of extracts (CNS-mediated effects on cross-lacing muscles). The aqueous extract of fungal material showed an increase in the motor activity of smooth muscles compared to standard caffeine, which indicates the ability of fungal extract to have a stimulating effect on the synapses. It was found that I. rickii extracts have an effect on smooth muscle contraction similar to the acetylcholine. It was shown that the greatest stimulating activity demonstrates an aqueous extract that may be a result of inhibitory effect of diethyl ether and ethanol on synapses. The described effects put on the agenda both the fractionation of active extracts and further experiments on the therapeutic applications of their described properties. As a field of possible application of this kind of substances can be considered the cardiovascular remodeling, the maintenance of smooth muscle tone during a number of surgical interventions, and the palliative cure of disseminated cancers.

Keywords

acetylcholine / central nervous system / diazepam / caffeine / medicinal mushrooms / receptor agonists / stimulation of motor activity / Inonotus

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Kiran Ramchandra Ranadive, Neeta Vijayrao Jagtap, Pradnya Nilesh Jagtap, Ivan V. Zmitrovich, Vladimir V. Perelygin. Investigating the effects of Inonotus rickii extracts on the muscle contraction intensity. Pharmacy Formulas, 2021, 3(1): 92-96 DOI:10.17816/phf63224

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