Modern Approaches to the Diagnosis of Cognitive Impairment and Alzheimer’s Disease: A Narrative Literature Review

Abstract

BACKGROUND: The aging of the world’s population leads to an increase in the prevalence of age-related diseases, including cognitive impairment. At the stage of dementia, therapeutic interventions become usually ineffective. Therefore, researchers and clinical practitioners today are looking for methods that allow for early diagnosis of cognitive impairment, including techniques that are based on the use of biological markers.

AIM: The aim of this literature review is to delve into scientific papers that are centered on modern laboratory tests for Alzheimer’s disease, including tests for biological markers at the early stages of cognitive impairment.

METHODS: The authors have carried out a descriptive review of scientific papers published from 2015 to 2023. Studies that are included in the PubMed and Web of Science electronic databases were analyzed. A descriptive analysis was used to summarized the gleaned information.

RESULTS: Blood and cerebrospinal fluid (CSF) biomarkers, as well as the advantages and disadvantages of their use, are reviewed. The most promising neurotrophic, neuroinflammatory, and genetic markers, including polygenic risk models, are also discussed.

CONCLUSION: The use of biomarkers in clinical practice will contribute to the early diagnosis of cognitive impairment associated with Alzheimer’s disease. Genetic screening tests can improve the detection threshold of preclinical abnormalities in the absence of obvious symptoms of cognitive decline. The active use of biomarkers in clinical practice, in combination with genetic screening for the early diagnosis of cognitive impairment in Alzheimer’s disease, can improve the timeliness and effectiveness of medical interventions.

Keywords

biomarkers / Alzheimer’s disease / dementia / diagnosis / cognitive impairment / polygenic risk

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Funding

Moscow Centre for Innovative Technologies in HealthcareМосковский центр инновационных технологий в здравоохранении(2708-1/22)

RIGHTS & PERMISSIONS

Ochneva A.G., Soloveva K.P., Savenkova V.I., Ikonnikova A.Y., Gryadunov D.A., Andryuschenko A.V.