Cognitive behavioural therapy in virtual reality treatments across mental health conditions: a systematic review

Merve Dilgul , Jasmine Martinez , Neelam Laxhman , Stefan Priebe , Victoria Bird

Consortium PSYCHIATRICUM ›› 2020, Vol. 1 ›› Issue (1) : 30 -46.

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Consortium PSYCHIATRICUM ›› 2020, Vol. 1 ›› Issue (1) : 30 -46. DOI: 10.17650/2712-7672-2020-1-1-30-46
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Cognitive behavioural therapy in virtual reality treatments across mental health conditions: a systematic review

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Abstract

Background. Virtual reality (VR) has been effectively used in the treatment of many mental health disorders. However, significant gaps exist in the literature. There is no treatment framework for researchers to use when developing new VR treatments. One recommended treatment across a range of diagnoses, which may be suitable for use in VR treatments, is Cognitive Behavioural Therapy (CBT). The aim of this systematic review is to investigate CBT treatment methods that utilize VR to treat mental health disorders.

Objectives. To investigate how CBT has been used in VR to treat mental health disorders and to report on the treatment characteristics (number of sessions, duration, and frequency) that are linked to effective and ineffective trials.

Methods. Studies were included if patients had a mental health diagnosis and their treatment included immersive VR technology and CBT principles. Data were extracted in relation to treatment characteristics and outcomes, and analysed using narrative synthesis.

Results. Ninety-three studies were analysed. Exposure-based VR treatments were mainly used to treat  anxietyrelated disorders. Treatments generally consisted of eight sessions, once a week for approximately one hour. VR treatments were commonly equal to or more effective than ‘traditional’ face-to-face methods. No specific treatment characteristics were linked to this effectiveness.

Conclusion. The number, frequency and duration of the VR treatment sessions identified in this review, could be used as a treatment framework by researchers and clinicians. This could potentially save researchers time and money when developing new interventions.

Keywords

Virtual Reality / Digital Interventions / Narrative Analysis / Mental Health Treatment / Cognitive Behavioural Therapy

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Merve Dilgul, Jasmine Martinez, Neelam Laxhman, Stefan Priebe, Victoria Bird. Cognitive behavioural therapy in virtual reality treatments across mental health conditions: a systematic review. Consortium PSYCHIATRICUM, 2020, 1(1): 30-46 DOI:10.17650/2712-7672-2020-1-1-30-46

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References

[1]

Maples-Keller JL, Bunnell BE, Kim SJ, Rothbaum BO. The Use of Virtual Reality Technology in the Treatment of Anxiety and Other Psychiatric Disorders. Harv Rev Psychiatry. 2017 May/Jun;25(3):103-113. doi: 10.1097/HRP.0000000000000138. PMID: 28475502;PMCID: PMC5421394.

[2]

Zeng N, Pope Z, Lee JE, Gao Z. Virtual Reality Exercise for Anxiety and Depression: A Preliminary Review of Current Research in an Emerging Field. J Clin Med. 2018 Mar 4;7(3):42. doi: 10.3390/jcm7030042. PMID:29510528; PMCID: PMC5867568.

[3]

Carl E, Stein AT, Levihn-Coon A, Pogue JR, Rothbaum B, Emmelkamp P, Asmundson GJG, Carlbring P, Powers MB. Virtual reality exposure therapy for anxiety and related disorders: A meta-analysis of randomized controlled trials. J Anxiety Disord. 2019 Jan;61:27-36. doi:10.1016/j.janxdis.2018.08.003. Epub 2018 Aug 10. PMID: 30287083.

[4]

Clus D, Larsen ME, Lemey C, Berrouiguet S. The Use of Virtual Reality in Patients with Eating Disorders: Systematic Review. J Med Internet Res. 2018 Apr 27;20(4):e157. doi: 10.2196/jmir.7898. PMID: 29703715; PMCID: PMC5948410.

[5]

Rus-Calafell M, Garety P, Sason E, Craig TJK, Valmaggia LR. Virtual reality in the assessment and treatment of psychosis: a systematic review of its utility, acceptability and effectiveness. Psychol Med. 2018 Feb;48(3):362-391. doi: 10.1017/S0033291717001945. Epub 2017 Jul 24. PMID: 28735593.

[6]

Wood DP, Murphy J, McLay R, Koffman R, Spira J, Obrecht RE, Pyne J, Wiederhold BK. Cost effectiveness of virtual reality graded exposure therapy with physiological monitoring for the treatment of combat related post traumatic stress disorder. Stud Health Technol Inform. 2009;144:223-9. PMID: 19592768.

[7]

Baños RM, Guillen V, Quero S, Garcia-Palacios A, Alcaniz M, Botella C. A virtual reality system for the treatment of stressrelated disorders: A preliminary analysis of efficacy compared to a standard cognitive behavioral program. International Journal of Human-Computer Studies. 2011 Aug 1;69(9):602-13. doi:10.1016/j.ijhcs.2011.06.002

[8]

Freeman D, Reeve S, Robinson A, Ehlers A, Clark D, Spanlang B, Slater M. Virtual reality in the assessment, understanding, and treatment of mental health disorders. Psychol Med. 2017 Oct;47(14):2393-2400. doi: 10.1017/S003329171700040X. Epub 2017 Mar 22. PMID: 28325167; PMCID: PMC5964457.

[9]

Oxford English Dictionary [Internet]. Oxford University Press. 2020. [cited 2020 August 10]. Available from: https://www.oed.com/.10. Riva G. Virtual reality in psychotherapy: review. Cyberpsychol Behav. 2005 Jun;8(3):220-30; discussion 231-40. doi: 10.1089/cpb.2005.8.220. PMID: 15971972.

[10]

Butler AC, Chapman JE, Forman EM, Beck AT. The empirical status of cognitive-behavioral therapy: a review of meta-analyses. Clin Psychol Rev. 2006 Jan;26(1):17-31. doi: 10.1016/j.cpr.2005.07.003.Epub 2005 Sep 30. PMID: 16199119.

[11]

Beck AT. Cognitive therapy and the emotional disorders. New York: International Universities Press; 1976. 356 p..

[12]

Fenn K, Byrne M. The key principles of cognitive behavioural therapy. InnovAiT Educ Inspir Gen Pract. 2013;6(9):579-85.doi:10.1177/1755738012471029.

[13]

Davies KS. Formulating the Evidence Based Practice Question: A Review of the Frameworks. EBLIP [Internet]. 2011;6(2):75-80 [cited 2020 August 10]. Available from: https://journals.library.ualberta.ca/eblip/index.php/EBLIP/article/view/9741

[14]

NHS choices [Internet]. Cognitive behavioural therapy (CBT). [modified 2019 July 16; cited 2020 August 10]. Available from: https://www.nhs.uk/conditions/cognitivebehavioural-therapy-cbt/.

[15]

Barfield W, Furness TA, editors. Virtual Environments and Advanced Interface Design. USA: Oxford University Press; 1995. 600 p.

[16]

Cruz-Neira C, Sandin D, DeFanti T. Surround-screen projectionbased virtual reality: the design and implementation of the CAVE. In: Proceedings of the 20st Annual Conference on Computer Graphics and Interactive Techniques, SIGGRAPH.1993. doi:10.1145/166117.166134.

[17]

Falconer CJ, Rovira A, King JA, Gilbert P, Antley A, Fearon P, Ralph N, Slater M, Brewin CR. Embodying self-compassion within virtual reality and its effects on patients with depression. BJPsych Open. 2016 Feb 15;2(1):74-80. doi: 10.1192/bjpo.bp.115.002147. PMID: 27703757; PMCID: PMC4995586.

[18]

Wallach HS, Safir MP, Bar-Zvi M. Virtual reality cognitive behavior therapy for public speaking anxiety: a randomized clinical trial. Behav Modif. 2009 May;33(3):314-38. doi: 10.1177/0145445509331926. Epub 2009 Mar 25. PMID: 19321811.

[19]

Popay J, Roberts H, Sowden A, et al. Guidance on the Conduct of Narrative Synthesis in Systematic Reviews. A Prod from 42 Consortium Psychiatricum | 2020 | Volume 1 | Issue 1 ESRC Methods Program. 2006;211-9. doi:10.1111/j.1523-536x.1995tb00261.x.

[20]

Effective Public Health Practice Project. Quality assessment tool for quantitative studies [Internet]. Eff Public Heal Pract Proj. 2010;2-5 [cited 2020 August 10]. Available from: https://www.ephpp.ca/quality-assessment-tool-for-quantitative-studies/

[21]

Michaliszyn D, Marchand A, Bouchard S, Martel MO, Poirier-Bisson J. A randomized, controlled clinical trial of in virtuo and in vivo exposure for spider phobia. Cyberpsychol Behav Soc Netw. 2010 Dec;13(6):689-95. doi: 10.1089/cyber.2009.0277. Epub 2010 May 3. PMID: 21142994.

[22]

Rizzo AS, Difede J, Rothbaum BO, Reger G, Spitalnick J, Cukor J, McLay R. Development and early evaluation of the Virtual Iraq/Afghanistan exposure therapy system for combat-related PTSD. Ann N Y Acad Sci. 2010 Oct;1208:114-25. doi: 10.1111/j.1749-6632.2010.05755.x. PMID: 20955333.

[23]

Riva G, Bacchetta M, Baruffi M, Molinari E. Virtual-reality-based multidimensional therapy for the treatment of body image disturbances in binge eating disorders: a preliminary controlled study. IEEE Trans Inf Technol Biomed. 2002 Sep;6(3):224-34. doi:10.1109/titb.2002.802372. PMID: 12381039.

[24]

Pot-Kolder RMCA, Geraets CNW, Veling W, van Beilen M, Staring ABP, Gijsman HJ, Delespaul PAEG, van der Gaag M. Virtual-realitybased cognitive behavioural therapy versus waiting list control for paranoid ideation and social avoidance in patients with psychotic disorders: a single-blind randomised controlled trial. Lancet Psychiatry. 2018 Mar;5(3):217-226. doi: 10.1016/S2215-0366(18)30053-1. Epub 2018 Feb 9. PMID: 29429948.

[25]

Pot-Kolder RMCA, Geraets CNW, Veling W, van Beilen M, Staring ABP, Gijsman HJ, Delespaul PAEG, van der Gaag M. Virtual-realitybased cognitive behavioural therapy versus waiting list control for paranoid ideation and social avoidance in patients with psychotic disorders: a single-blind randomised controlled trial. Lancet Psychiatry. 2018 Mar;5(3):217-226. doi: 10.1016/S2215-0366(18)30053-1. Epub 2018 Feb 9. PMID: 29429948.

[26]

Freeman D, Haselton P, Freeman J, Spanlang B, Kishore S, Albery E, Denne M, Brown P, Slater M, Nickless A. Automated psychological therapy using immersive virtual reality for treatment of fear of heights: a single-blind, parallel-group, randomised controlled trial. Lancet Psychiatry. 2018 Aug;5(8):625-632. doi: 10.1016/S2215-0366(18)30226-8. Epub 2018 Jul 11. PMID: 30007519; PMCID: PMC6063994.

[27]

Anderson PL, Zimand E, Hodges LF, Rothbaum BO. Cognitive behavioral therapy for public-speaking anxiety using virtual reality for exposure. Depress Anxiety. 2005;22(3):156-8. doi: 10.1002/da.20090. PMID: 16231290.

[28]

Malbos E, Mestre DR, Note ID, Gellato C. Virtual reality and claustrophobia: multiple components therapy involving game editor virtual environments exposure. Cyberpsychol Behav. 2008 Dec;11(6):695-7. doi: 10.1089/cpb.2007.0246.PMID: 18954278.

[29]

McLay R, Ram V, Murphy J, Spira J, Wood DP, Wiederhold MD, Wiederhold BK, Johnston S, Reeves D. Effect of virtual reality PTSD treatment on mood and neurocognitive outcomes. Cyberpsychol Behav Soc Netw. 2014 Jul;17(7):439-46. doi:10.1089/cyber.2013.0383. Epub 2014 Mar 17. PMID: 24635120.

[30]

Pericot-Valverde I, García-Rodríguez O, Gutiérrez-Maldonado J, Secades-Villa R. Individual variables related to craving reduction in cue exposure treatment. Addict Behav. 2015 Oct;49:59-63. doi: 10.1016/j.addbeh.2015.05.013.Epub 2015 May 23. PMID: 26047836.

[31]

Pericot-Valverde I, Secades-Villa R, Gutiérrez-Maldonado J, García-Rodríguez O. Effects of systematic cue exposure through virtual reality on cigarette craving. Nicotine Tob Res. 2014 Nov;16(11):1470-7. doi: 10.1093/ntr/ntu104. Epub 2014 Jun 23.PMID: 24962558; PMCID: PMC4342674.

[32]

Riva G, Bacchetta M, Baruffi M, Cirillo G, Molinari E. Virtual reality environment for body image modification: A multidimensional therapy for the treatment of body image in obesity and related pathologies. CyberPsychology & Behavior. 2000 Jun 1;3(3):421-31.doi:10.1089/10949310050078887

[33]

Rothbaum BO, Hodges LF, Ready D, Graap K, Alarcon RD. Virtual reality exposure therapy for Vietnam veterans with posttraumatic stress disorder. J Clin Psychiatry. 2001 Aug;62(8):617-22. doi:10.4088/jcp.v62n0808. PMID: 11561934.

[34]

Wald J. Efficacy of virtual reality exposure therapy for driving phobia: A multiple baseline across-subjects design. Behavior Therapy. 2004 Jun 1;35(3):621-35. doi:10.1016/S0005-7894(04)80035-2

[35]

Walshe DG, Lewis EJ, Kim SI, O'Sullivan K, Wiederhold BK.Exploring the use of computer games and virtual reality in exposure therapy for fear of driving following a motor vehicle accident. Cyberpsychol Behav. 2003 Jun;6(3):329-34. doi:10.1089/109493103322011641. PMID: 12855091.

[36]

Wiederhold BK, Jang DP, Kim SI, Wiederhold MD.Physiological monitoring as an objective tool in virtual reality therapy. Cyberpsychol Behav. 2002 Feb;5(1):77-82. doi:10.1089/109493102753685908. PMID: 11990977.

[37]

Znaidi F, Viaud-Delmon I, Jouvent R. Generic virtual reality treatment applied to space-related phobias. Annu Rev CyberTher Telemed. 2006 Jun 1;4:175-9.

[38]

Baños RM, Botella C, Perpiñá C, Alcañiz M, Lozano JA, Osma J, Gallardo M. Virtual reality treatment of flying phobia. IEEE Trans Inf Technol Biomed. 2002 Sep;6(3):206-12. doi: 10.1109/titb.2002.802380. PMID: 12381036.

[39]

Beidel DC, Frueh BC, Neer SM, Lejuez CW. The efficacy of Trauma Management Therapy: A controlled pilot investigation of a three-week intensive outpatient program for combat-related PTSD. J Anxiety Disord. 2017 Aug;50:23-32. doi: 10.1016/j.janxdis.2017.05.001. Epub 2017 May 11. PMID: 28545005.

[40]

Botella C, Baños RM, Villa H, Perpiñá C, García-Palacios A. Virtual reality in the treatment of claustrophobic fear: A controlled, multiple-baseline design. Behav Ther. 2000 Jun 1;31(3):583-95.doi:10.1016/S0005-7894(00)80032-5

[41]

Botella C, Osma J, Garcia-Palacios A, Quero S, Baños RM.Treatment of flying phobia using virtual reality: data from a 1-year follow-up using a multiple baseline design. Clin Psychol Psychother. 2004 Sep;11(5):311-23. doi:10.1002/cpp.404

[42]

Coelho CM, Santos JA, Silvério J, Silva CF. Virtual reality and acrophobia: one-year follow-up and case study. Cyberpsychol Behav. 2006 Jun;9(3):336-41. doi: 10.1089/cpb.2006.9.336.PMID: 16780401.

[43]

Côté S, Bouchard S. Documenting the efficacy of virtual reality exposure with psychophysiological and information processing measures. Appl Psychophysiol Biofeedback. 2005 Sep;30(3):217-32. doi: 10.1007/s10484-005-6379-x. PMID: 16167187.

[44]

Grillon H, Riquier F, Herbelin B, Thalmann D. Virtual reality as therapeutic tool in the confines of social anxiety disorder treatment. Int J Disabil Hum Dev. 2006;5(ARTICLE):243-50. doi:10.1515/IJDHD.2006.5.3.243.

[45]

Kahan M, Tanzer J, Darvin D, Borer F. Virtual reality-assisted cognitive-behavioral treatment for fear of flying: Acute treatment Consortium Psychiatricum | 2020 | Volume 1 | Issue 1 43 and follow-up. Cyberpsychol Behav. 2000 Jun; 1;3(3):387-92.doi:10.1089/10949310050078832

[46]

Bullinger AH, Angehrn I, Wiederhold BK, Mueller-Spahn F, Mager R. Treating acrophobia in a virtual environment. Annu Rev cybertherapy Telemed. 2005 Jul;3:93-100.

[47]

Difede J, Cukor J, Jayasinghe N, Patt I, Jedel S, Spielman L, Giosan C, Hoffman HG. Virtual reality exposure therapy for the treatment of posttraumatic stress disorder following September 11, 2001. J Clin Psychiatry. 2007 Nov;68(11):1639-47. PMID: 18052556.

[48]

Garcia-Palacios A, Hoffman H, Carlin A, Furness TA 3rd, Botella C. Virtual reality in the treatment of spider phobia: a controlled study. Behav Res Ther. 2002 Sep;40(9):983-93. doi: 10.1016/s0005-7967(01)00068-7. PMID: 12296495.

[49]

Harris SR, Kemmerling RL, North MM. Brief virtual reality therapy for public speaking anxiety. Cyberpsychol Behav.2002 Dec;5(6):543-50. doi: 10.1089/109493102321018187.PMID: 12556117.

[50]

Loucks L, Yasinski C, Norrholm SD, Maples-Keller J, Post L, Zwiebach L, Fiorillo D, Goodlin M, Jovanovic T, Rizzo AA, Rothbaum BO. You can do that?!: Feasibility of virtual reality exposure therapy in the treatment of PTSD due to military sexual trauma. J Anxiety Disord. 2019 Jan;61:55-63. doi: 10.1016/j.janxdis.2018.06.004. Epub 2018 Jun 18. PMID: 30005843.

[51]

Pot-Kolder RMCA, Geraets CNW, Veling W, van Beilen M, Staring ABP, Gijsman HJ, Delespaul PAEG, van der Gaag M. Virtual-realitybased cognitive behavioural therapy versus waiting list control for paranoid ideation and social avoidance in patients with psychotic disorders: a single-blind randomised controlled trial. Lancet Psychiatry. 2018 Mar;5(3):217-226. doi: 10.1016/S2215-0366(18)30053-1. Epub 2018 Feb 9. PMID: 29429948.

[52]

Rothbaum BO, Hodges L, Smith S, Lee JH, Price L. A controlled study of virtual reality exposure therapy for the fear of flying. J Consult Clin Psychol. 2000 Dec;68(6):1020-6. doi: 10.1037//0022-006x.68.6.1020. PMID: 11142535.

[53]

Moldovan R, David D. One session treatment of cognitive and behavioral therapy and virtual reality for social and specific phobias. Preliminary results from a randomized clinical trial. Journal of Evidence-Based Psychotherapies [Internet].2014;14(1):67-83. [cited 2020 August 10]. Available from: https://www.researchgate.net/publication/267842953

[54]

Krijn M, Emmelkamp PM, Biemond R, de Wilde de Ligny C, Schuemie MJ, van der Mast CA. Treatment of acrophobia in virtual reality: the role of immersion and presence. Behav Res Ther. 2004;42(2):229-39. doi: 10.1016/S0005-7967(03)00139-6.PMID: 14975783.

[55]

Meyerbröker K, Morina N, Kerkhof G, Emmelkamp PM. Virtual reality exposure treatment of agoraphobia: a comparison of computer automatic virtual environment and headmounted display. Stud Health Technol Inform. 2011;167:51-6.PMID: 21685641.

[56]

Price M, Anderson P. The role of presence in virtual reality exposure therapy. J Anxiety Disord. 2007;21(5):742-51. doi:10.1016/j.janxdis.2006.11.002. Epub 2006 Dec 4. PMID: 17145164; PMCID: PMC3670421.

[57]

Beidel DC, Frueh BC, Neer SM, Bowers CA, Trachik B, Uhde TW, Grubaugh A. Trauma management therapy with virtual-reality augmented exposure therapy for combat-related PTSD: A randomized controlled trial. J Anxiety Disord. 2019 Jan;61:64-74. doi:10.1016/j.janxdis.2017.08.005. Epub 2017 Aug 23. PMID: 28865911.

[58]

Bordnick PS, Traylor AC, Carter BL, Graap KM. A Feasibility Study of Virtual Reality-Based Coping Skills Training for Nicotine Dependence. Res Soc Work Pract. 2012 May;22(3):293-300. doi: 10.1177/1049731511426880. PMID: 25484549; PMCID: PMC4254682.

[59]

Lima J, McCabe-Bennett H, Antony MM. Treatment of Storm Fears Using Virtual Reality and Progressive Muscle Relaxation. Behav Cogn Psychother. 2018 Mar;46(2):251-256. doi: 10.1017/S1352465817000674. Epub 2017 Oct 30. PMID: 29081326.

[60]

Maltby N, Kirsch I, Mayers M, Allen GJ. Virtual reality exposure therapy for the treatment of fear of flying: a controlled investigation. J Consult Clin Psychol. 2002 Oct;70(5):1112-8. doi:10.1037//0022-006x.70.5.1112. PMID: 12362961.

[61]

Marco JH, Perpiñá C, Botella C. Effectiveness of cognitive behavioral therapy supported by virtual reality in the treatment of body image in eating disorders: one year followup. Psychiatry Res. 2013 Oct 30;209(3):619-25. doi: 10.1016/j. psychres.2013.02.023. Epub 2013 Mar 15. PMID: 23499231.

[62]

McLay RN, Wood DP, Webb-Murphy JA, Spira JL, Wiederhold MD, Pyne JM, Wiederhold BK. A randomized, controlled trial of virtual reality-graded exposure therapy for post-traumatic stress disorder in active duty service members with combat-related post-traumatic stress disorder. Cyberpsychol Behav Soc Netw. 2011 Apr;14(4):223-9. doi: 10.1089/cyber.2011.0003. Epub 2011 Feb 20. PMID: 21332375.

[63]

Mühlberger A, Herrmann MJ, Wiedemann GC, Ellgring H, Pauli P. Repeated exposure of flight phobics to flights in virtual reality. Behav Res Ther. 2001 Sep;39(9):1033-50. doi: 10.1016/s0005-7967(00)00076-0. PMID: 11520010.

[64]

Riva G, Bacchetta M, Baruffi M, Molinari E. Virtual-reality-based multidimensional therapy for the treatment of body image disturbances in binge eating disorders: a preliminary controlled study. IEEE Trans Inf Technol Biomed. 2002 Sep;6(3):224-34. doi:10.1109/titb.2002.802372. PMID: 12381039.

[65]

Ferrer-García M, Gutiérrez-Maldonado J, Pla-Sanjuanelo J, Vilalta-Abella F, Riva G, Clerici M, Ribas-Sabaté J, Andreu-Gracia A, Fernandez-Aranda F, Forcano L, Riesco N, Sánchez I, Escandón-Nagel N, Gomez-Tricio O, Tena V, Dakanalis A. A Randomised Controlled Comparison of Second-Level Treatment Approaches for Treatment-Resistant Adults with Bulimia Nervosa and Binge Eating Disorder: Assessing the Benefits of Virtual Reality Cue Exposure Therapy. Eur Eat Disord Rev. 2017 Nov;25(6):479-490.doi: 10.1002/erv.2538. Epub 2017 Aug 14. PMID: 28804985.

[66]

Riva G, Bacchetta M, Cesa G, Conti S, Molinari E. The use of VR in the treatment of eating disorders. Stud Health Technol Inform. 2004;99:121-63. doi:10.3233/978-1-60750-943-1-121. PMID: 15295149.

[67]

Vincelli F, Anolli L, Bouchard S, Wiederhold BK, Zurloni V, Riva G. Experiential cognitive therapy in the treatment of panic disorders with agoraphobia: a controlled study. Cyberpsychol Behav. 2003 Jun;6(3):321-8. doi: 10.1089/109493103322011632. PMID: 12855090.

[68]

Wiederhold BK, Gevirtz RN, Spira JL. Virtual reality exposure therapy vs. imagery desensitization therapy in the treatment of flying phobia. In: Riva G, Galimberti C, editors. Towards cyberpsychology. Amsterdam: IOSpress; 2001. p. 254-72.

[69]

Botella C, Villa H, García Palacios A, Quero S, Baños RM, Alcaniz M. The use of VR in the treatment of panic disorders and agoraphobia. Stud Health Technol Inform. 2004;99:73-90.doi:10.3233/978-1-60750-943-1-73. PMID: 15295147.

[70]

Bouchard S, Dumoulin S, Robillard G, Guitard T, Klinger É, Forget H, Loranger C, Roucaut FX. Virtual reality compared with in vivoexposure in the treatment of social anxiety disorder:44 Consortium Psychiatricum | 2020 | Volume 1 | Issue 1 a three-arm randomised controlled trial. Br J Psychiatry. 2017 Apr;210(4):276-283. doi: 10.1192/bjp.bp.116.184234. Epub 2016 Dec 15. PMID: 27979818.

[71]

Cesa GL, Manzoni GM, Bacchetta M, Castelnuovo G, Conti S, Gaggioli A, Mantovani F, Molinari E, Cárdenas-López G, Riva G. Virtual reality for enhancing the cognitive behavioral treatment of obesity with binge eating disorder: randomized controlled study with one-year follow-up. J Med Internet Res. 2013 Jun 12;15(6):e113. doi: 10.2196/jmir.2441. PMID: 23759286; PMCID: PMC3713949.

[72]

Freeman D, Haselton P, Freeman J, Spanlang B, Kishore S, Albery E, Denne M, Brown P, Slater M, Nickless A. Automated psychological therapy using immersive virtual reality for treatment of fear of heights: a single-blind, parallel-group, randomised controlled trial. Lancet Psychiatry. 2018 Aug;5(8):625-632. doi: 10.1016/S2215-0366(18)30226-8. Epub 2018 Jul 11.PMID: 30007519; PMCID: PMC6063994.

[73]

Gamito P, Oliveira J, Morais D, Oliveira S, Duarte N, Saraiva T, Pombal M, Rosa P. Virtual Reality Therapy Controlled Study for War Veterans with PTSD. Preliminary Results. Stud Health Technol Inform. 2009;144:269-72. PMID: 19592779.

[74]

Gujjar KR, van Wijk A, Sharma R, de Jongh A. Virtual Reality Exposure Therapy for the Treatment of Dental Phobia: A Controlled Feasibility Study. Behav Cogn Psychother. 2018 May;46(3):367-373. doi: 10.1017/S1352465817000534. Epub 2017 Sep 14. PMID: 28903790.

[75]

Krijn M, Emmelkamp PM, Olafsson RP, Bouwman M, van Gerwen LJ, Spinhoven P, Schuemie MJ, van der Mast CA. Fear of flying treatment methods: virtual reality exposure vs. cognitive behavioral therapy. Aviat Space Environ Med. 2007 Feb;78(2):121-8. PMID: 17310883.

[76]

La Paglia F, La Cascia C, Rizzo R, Sideli L, Francomano A, La Barbera D. Cognitive rehabilitation of schizophrenia through NeuroVr training. Annual Review of Cybertherapy and Telemedicine 2013: Positive Technology and Health Engagement for Healthy Living and Active Ageing. Stud Health Technol Inform. 2013;191:158-62. doi:10.3233/978-1-61499-282-0-158.PMID: 23792865.

[77]

Kampmann IL, Emmelkamp PM, Hartanto D, Brinkman WP, Zijlstra BJ, Morina N. Exposure to virtual social interactions in the treatment of social anxiety disorder: A randomized controlled trial. Behav Res Ther. 2016 Feb;77:147-56. doi: 10.1016/j.brat.2015.12.016. Epub 2015 Dec 29. PMID: 26752328.

[78]

Meyerbroeker K, Morina N, Kerkhof GA, Emmelkamp PM. Virtual reality exposure therapy does not provide any additional value in agoraphobic patients: a randomized controlled trial. Psychother Psychosom. 2013;82(3):170-6. doi: 10.1159/000342715. Epub 2013 Mar 27. PMID: 23548832.

[79]

Reger GM, Koenen-Woods P, Zetocha K, Smolenski DJ, Holloway KM, Rothbaum BO, Difede J, Rizzo AA, Edwards-Stewart A, Skopp NA, Mishkind M, Reger MA, Gahm GA. Randomized controlled trial of prolonged exposure using imaginal exposure vs. virtual reality exposure in active duty soldiers with deployment-related posttraumatic stress disorder (PTSD). J Consult Clin Psychol. 2016 Nov;84(11):946-959. doi: 10.1037/ccp0000134. Epub 2016 Sep 8. PMID: 27606699.

[80]

Anderson PL, Price M, Edwards SM, Obasaju MA, Schmertz SK, Zimand E, Calamaras MR. Virtual reality exposure therapy for social anxiety disorder: a randomized controlled trial. J Consult Clin Psychol. 2013 Oct;81(5):751-60. doi: 10.1037/a0033559. Epub 2013 Jun 24. PMID: 23796315.

[81]

Tortella-Feliu M, Botella C, Llabrés J, Bretón-López JM, del Amo AR, Baños RM, Gelabert JM. Virtual reality versus computeraided exposure treatments for fear of flying. Behav Modif. 2011 Jan;35(1):3-30. doi: 10.1177/0145445510390801. PMID: 21177516.

[82]

Wallach HS, Safir MP, Bar-Zvi M. Virtual reality cognitive behavior therapy for public speaking anxiety: a randomized clinical trial. Behav Modif. 2009 May;33(3):314-38. doi:10.1177/0145445509331926. Epub 2009 Mar 25. PMID: 19321811.

[83]

Botella C, García-Palacios A, Villa H, Baños RM, Quero S, Alcañiz M, Riva G. Virtual reality exposure in the treatment of panic disorder and agoraphobia: A controlled study. Clin Psychol Psychother. 2007 May;14(3):164-75. doi:10.1002/cpp.524

[84]

Chirită V, Ilinca M, Chiriţă R, Bîşcă M, Chele G, et al. Virtual therapy in patients with depression. Preliminary observation. Annu Rev CyberTherapy Telemed. 2006;9(6):664-5.

[85]

Huang MP, Himle J, Alessi NE. Vivid visualization in the experience of phobia in virtual environments: Preliminary results. CyberPsychology & Behavior. 2000;3(3). doi:10.1089/10949310050078742.

[86]

Rus-Calafell M, Gutiérrez-Maldonado J, Botella C, Baños RM. Virtual reality exposure and imaginal exposure in the treatment of fear of flying: a pilot study. Behav Modif. 2013 Jul;37(4):568-90. doi: 10.1177/0145445513482969. Epub 2013 Apr 12. PMID: 23585557.

[87]

McLay RN, Baird A, Webb-Murphy J, Deal W, Tran L, Anson H, Klam W, Johnston S. A Randomized, Head-to-Head Study of Virtual Reality Exposure Therapy for Posttraumatic Stress Disorder. Cyberpsychol Behav Soc Netw. 2017 Apr;20(4):218-224. doi:10.1089/cyber.2016.0554. Epub 2017 Feb 27. PMID: 28394217.

[88]

Pelissolo A, Zaoui M, Aguayo G, Yao SN, Roche S, Ecochard R, Gueyffier F, Pull C, Berthoz A, Jouvent R, Cottraux J. Virtual reality exposure therapy versus cognitive behavior therapy for panic disorder with agoraphobia: a randomized comparison study. J CyberTherapy Rehabil. 2012 Mar 1;5(1):35-43.

[89]

Robillard G, Bouchard S, Dumoulin S, Guitard T, Klinger E. Using virtual humans to alleviate social anxiety: preliminary report from a comparative outcome study. Stud Health Technol Inform. 2010;154:57-60. doi:10.3233/978-1-60750-561-7-57. PMID:20543270.

[90]

Roy MJ, Francis J, Friedlander J, Banks-Williams L, Lande RG, Taylor P, Blair J, McLellan J, Law W, Tarpley V, Patt I. Improvement in cerebral function with treatment of posttraumatic stress disordera. NYASA. 2010 Oct;1208(1):142-9. doi:10.1111/j.1749-6632.2010.05689.x

[91]

de Quervain DJ, Bentz D, Michael T, Bolt OC, Wiederhold BK, Margraf J, Wilhelm FH. Glucocorticoids enhance extinctionbased psychotherapy. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6621-5. doi: 10.1073/pnas.1018214108. Epub 2011 Mar 28. PMID: 21444799; PMCID: PMC3081033.

[92]

Difede J, Cukor J, Wyka K, Olden M, Hoffman H, Lee FS, Altemus M. D-cycloserine augmentation of exposure therapy for posttraumatic stress disorder: a pilot randomized clinical trial. Neuropsychopharmacology. 2014 Apr;39(5):1052-8. doi: 10.1038/npp.2013.317. Epub 2013 Nov 12. PMID: 24217129; PMCID:PMC3957110.

[93]

Mühlberger A, Wiedemann G, Pauli P. Efficacy of a one-session virtual reality exposure treatment for fear of flying. Psychother Res. 2003 Jan 1;13(3):323-36. doi: 10.1093/ptr/kpg030.

[94]

PMID: 21827246.

[95]

Pallavicini F, Algeri D, Repetto C, Gorini A, Riva G. Biofeedback, virtual reality and mobile phones in the treatment of Generalized Consortium Psychiatricum | 2020 | Volume 1 | Issue 1 45 Anxiety Disorder (GAD): A phase-2 controlled clinical trial. J Cyber Ther Rehabil. 2009 Dec 1;2(4):315-27.

[96]

Perpiñá C, Botella C, Baños R, Marco H, Alcañiz M, Quero S. Body image and virtual reality in eating disorders: is exposure to virtual reality more effective than the classical body image treatment? Cyberpsychol Behav. 1999;2(2):149-55. doi: 10.1089/cpb.1999.2.149. PMID: 19178251.

[97]

Ressler KJ, Rothbaum BO, Tannenbaum L, Anderson P, Graap K, Zimand E, Hodges L, Davis M. Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004 Nov;61(11):1136-44. doi: 10.1001/archpsyc.61.11.1136. PMID: 15520361.

[98]

Rothbaum BO, Price M, Jovanovic T, Norrholm SD, Gerardi M, Dunlop B, Davis M, Bradley B, Duncan EJ, Rizzo A, Ressler KJ. A randomized, double-blind evaluation of D-cycloserine or alprazolam combined with virtual reality exposure therapy for posttraumatic stress disorder in Iraq and Afghanistan War veterans. Am J Psychiatry. 2014 Jun;171(6):640-8. doi: 10.1176/appi.ajp.2014.13121625. PMID: 24743802; PMCID: PMC4115813.

[99]

Shiban Y, Pauli P, Mühlberger A. Effect of multiple context exposure on renewal in spider phobia. Behav Res Ther. 2013 Feb;51(2):68-74. doi: 10.1016/j.brat.2012.10.007. Epub 2012 Nov 11. PMID: 23261707.

[100]

Shiban Y, Schelhorn I, Pauli P, Mühlberger A. Effect of combined multiple contexts and multiple stimuli exposure in spider phobia: A randomized clinical trial in virtual reality. Behav Res Ther. 2015 Aug;71:45-53. doi: 10.1016/j.brat.2015.05.014. Epub 2015 May 28. PMID: 26072451.

[101]

Shiban Y, Peperkorn H, Alpers GW, Pauli P, Mühlberger A. Influence of perceptual cues and conceptual information on the activation and reduction of claustrophobic fear. J Behav Ther Exp Psychiatry. 2016 Jun;51:19-26. doi: 10.1016/j.jbtep.2015.11.002. Epub 2015 Nov 26. PMID: 26687921.

[102]

Shiban Y, Diemer J, Müller J, Brütting-Schick J, Pauli P, Mühlberger A. Diaphragmatic breathing during virtual reality exposure therapy for aviophobia: functional coping strategy or avoidance behavior? a pilot study. BMC Psychiatry. 2017 Jan 18;17(1):29. doi: 10.1186/s12888-016-1181-2. PMID: 28100203; PMCID: PMC5242013.

[103]

Freeman D, Bradley J, Antley A, Bourke E, DeWeever N, Evans N, Černis E, Sheaves B, Waite F, Dunn G, Slater M, Clark DM. Virtual reality in the treatment of persecutory delusions: randomised controlled experimental study testing how to reduce delusional conviction. Br J Psychiatry. 2016 Jul;209(1):62-7. doi: 10.1192/bjp.bp.115.176438. Epub 2016 May 5. PMID: 27151071; PMCID: PMC4929408.

[104]

Tart CD, Handelsman PR, Deboer LB, Rosenfield D, Pollack MH, Hofmann SG, Powers MB, Otto MW, Smits JA. Augmentation of exposure therapy with post-session administration of D-cycloserine. J Psychiatr Res. 2013 Feb;47(2):168-74. doi:10.1016/j.jpsychires.2012.09.024. Epub 2012 Oct 23. PMID:23098672; PMCID: PMC3732105.

[105]

Gorini A, Pallavicini F, Algeri D, Repetto C, Gaggioli A, Riva G. Virtual reality in the treatment of generalized anxiety disorders. Stud Health Technol Inform. 2010;154:39-43. doi:10.3233/978-1-60750-561-7-39. PMID: 20543266.

[106]

Herrmann MJ, Katzorke A, Busch Y, Gromer D, Polak T, Pauli P, Deckert J. Medial prefrontal cortex stimulation accelerates therapy response of exposure therapy in acrophobia. Brain Stimul. 2017 Mar-Apr;10(2):291-297. doi: 10.1016/j.brs.2016.11.007. Epub 2016 Nov 14. PMID: 27931887.

[107]

Hoffman HG, Garcia-Palacios A, Carlin A, Furness Iii TA, Botella-Arbona C. Interfaces that heal: coupling real and virtual objects to treat spider phobia. Int J Hum Comput Interact. 2003 Oct 1;16(2):283-300. doi:10.1207/S15327590IJHC1602_08.

[108]

Kleim B, Wilhelm FH, Temp L, Margraf J, Wiederhold BK, Rasch B. Sleep enhances exposure therapy. Psychol Med. 2014 May;44(7):1511-9. doi: 10.1017/S0033291713001748. Epub 2013 Jul 10. PMID: 23842278.

[109]

Krijn M, Emmelkamp PM, Olafsson RP, Schuemie MJ, van der Mast CA. Do self-statements enhance the effectiveness of virtual reality exposure therapy? A comparative evaluation in acrophobia. Cyberpsychol Behav. 2007 Jun;10(3):362-70. doi: 10.1089/cpb.2006.9943. PMID: 17594260.

[110]

Malbos E, Rapee RM, Kavakli M. Isolating the effect of Virtual Reality Based Exposure Therapy for agoraphobia: a comparative trial. Stud Health Technol Inform. 2011;167:45-50. PMID: 21685640.21.

[111]

Maples-Keller JL, Price M, Jovanovic T, Norrholm SD, Odenat L, Post L, Zwiebach L, Breazeale K, Gross R, Kim SJ, Rothbaum BO. Targeting memory reconsolidation to prevent the return of fear in patients with fear of flying. Depress Anxiety. 2017 Jul;34(7):610-620. doi: 10.1002/da.22626. Epub 2017 Apr 5. PMID: 28380277.

[112]

Botella Arbona C, Bretón-López J, Serrano Zárate B, García-Palacios A, Quero S, Baños Rivera RM. Treatment of flying phobia using virtual reality exposure with or without cognitive restructuring: Participants’ preferences. Rev Psicopatol y Psicol Clin. 2014 Dec 1;19(3):157-69.doi:10.5944/rppc.vol.19.num.3.2014.13898.

[113]

Quero S, Pérez-Ara MÁ, Bretón-López J, García-Palacios A, Baños RM, Botella C. Acceptability of virtual reality interoceptive exposure for the treatment of panic disorder with agoraphobia. British Journal of Guidance & Counselling. 2014 Mar 15;42(2):123-37.doi: 10.1080/03069885.2013.852159

[114]

Emmelkamp PM, Krijn M, Hulsbosch AM, de Vries S, Schuemie MJ, van der Mast CA. Virtual reality treatment versus exposure in vivo: a comparative evaluation in acrophobia. Behav Res Ther. 2002 May;40(5):509-16. doi: 10.1016/s0005-7967(01)00023-7.PMID: 12038644.

[115]

Levy F, Leboucher P, Rautureau G, Jouvent R. E-virtual reality exposure therapy in acrophobia: A pilot study. J Telemed Telecare. 2016 Jun;22(4):215-20. doi: 10.1177/1357633X15598243. Epub 2015 Aug 6.PMID: 26253746.

[116]

Lindner P, Miloff A, Fagernäs S, Andersen J, Sigeman M, Andersson G, Furmark T, Carlbring P. Therapist-led and self-led one-session virtual reality exposure therapy for public speaking anxiety with consumer hardware and software: A randomized controlled trial. J Anxiety Disord. 2019 Jan;61:45-54. doi: 10.1016/j.janxdis.2018.07.003.Epub 2018 Jul 24. Erratum in: J Anxiety Disord. 2019 May;64:90. PMID: 30054173.

[117]

Stupar-Rutenfrans S, Ketelaars LEH, van Gisbergen MS. Beat the Fear of Public Speaking: Mobile 360° Video Virtual Reality Exposure Training in Home Environment Reduces Public Speaking Anxiety. Cyberpsychol Behav Soc Netw. 2017 Oct;20(10):624-633. doi: 10.1089/cyber.2017.0174. PMID: 29039704.

[118]

Baños RM, Botella C, Perpiñá C, Alcañiz M, Lozano JA, Osma J, Gallardo M. Virtual reality treatment of flying phobia. IEEE Trans Inf Technol Biomed. 2002 Sep;6(3):206-12. doi: 10.1109/titb.2002.802380. PMID: 12381036.

[119]

Coelho CM, Santos JA, Silvério J, Silva CF. Virtual reality and acrophobia: one-year follow-up and case study. Cyberpsychol Behav. 2006 Jun;9(3):336-41. doi: 10.1089/cpb.2006.9.336. PMID: 16780401.46 Consortium Psychiatricum | 2020 | Volume 1 | Issue 1

[120]

Côté S, Bouchard S. Documenting the efficacy of virtual reality exposure with psychophysiological and information processing measures. Appl Psychophysiol Biofeedback. 2005 Sep;30(3):217-32.doi: 10.1007/s10484-005-6379-x. PMID: 16167187.

[121]

Riva G, Bacchetta M, Baruffi M, Cirillo G, Molinari E. Virtual reality environment for body image modification: A multidimensional therapy for the treatment of body image in obesity and related pathologies. CyberPsychology Behav. 2000 Jun;1;3(3):421-31. doi:10.1089/10949310050078887.

[122]

Botella C, Villa H, García Palacios A, Quero S, Baños RM, Alcaniz M. The use of VR in the treatment of panic disorders and agoraphobia. Stud Health Technol Inform. 2004;99:73-90. doi: 10.3233/978-1-60750-943-1-73. PMID: 15295147.

[123]

Pelissolo A, Zaoui M, Aguayo G, Yao SN, Roche S, Ecochard R, Gueyffier F, Pull C, Berthoz A, Jouvent R, Cottraux J. Virtual reality exposure therapy versus cognitive behavior therapy for panic disorder with agoraphobia: a randomized comparison study. J Cybertherapy Rehabil. 2012 Mar;1;5(1):35-43.

[124]

Marco JH, Perpiñá C, Botella C. Effectiveness of cognitive behavioral therapy supported by virtual reality in the treatment of body image in eating disorders: one year follow-up. Psychiatry Res. 2013 Oct 30;209(3):619-25. doi: 10.1016/j.psychres.2013.02.023. Epub 2013 Mar 15. PMID: 23499231.

[125]

Rus-Calafell M, Gutiérrez-Maldonado J, Botella C, Baños RM. Virtual reality exposure and imaginal exposure in the treatment of fear of flying: a pilot study. Behav Modif. 2013 Jul;37(4):568-90. doi:10.1177/0145445513482969. Epub 2013 Apr 12. PMID: 23585557.

[126]

Roy MJ, Francis J, Friedlander J, Banks-Williams L, Lande RG, Taylor P, Blair J, McLellan J, Law W, Tarpley V, Patt I, Yu H, Mallinger A, Difede J, Rizzo A, Rothbaum B. Improvement in cerebral function with treatment of posttraumatic stress disorder. Ann N Y Acad Sci. 2010 Oct;1208:142-9. doi: 10.1111/j.1749-6632.2010.05689.x. PMID: 20955336.

[127]

Beidel DC, Frueh BC, Neer SM, Bowers CA, Trachik B, Uhde TW, Grubaugh A. Trauma management therapy with virtual-reality augmented exposure therapy for combat-related PTSD: A randomized controlled trial. J Anxiety Disord. 2019 Jan;61:64-74. doi: 10.1016/j.janxdis.2017.08.005. Epub 2017 Aug 23. PMID: 28865911.

[128]

Lima J, McCabe-Bennett H, Antony MM. Treatment of Storm Fears Using Virtual Reality and Progressive Muscle Relaxation. Behav Cogn Psychother. 2018 Mar;46(2):251-256. doi: 10.1017/S1352465817000674. Epub 2017 Oct 30. PMID: 29081326.

[129]

Maltby N, Kirsch I, Mayers M, Allen GJ. Virtual reality exposure therapy for the treatment of fear of flying: a controlled investigation. J Consult Clin Psychol. 2002 Oct;70(5):1112-8. doi: 10.1037//0022-006x.70.5.1112. PMID: 12362961.

[130]

Tortella-Feliu M, Botella C, Llabrés J, Bretón-López JM, del Amo AR, Baños RM, Gelabert JM. Virtual reality versus computer-aided exposure treatments for fear of flying. Behav Modif. 2011 Jan;35(1):3-30. doi: 10.1177/0145445510390801. PMID: 21177516.

[131]

Glantz K, Durlach NI, Barnett RC, Aviles WA. Virtual reality (VR) and psychotherapy: opportunities and challenges. Presence (Camb). 1997 Feb;6(1):87-105. doi: 10.1162/pres.1997.6.1.87. PMID: 11540645.

[132]

Fodor LA, Coteț CD, Cuijpers P, Szamoskozi Ș, David D, Cristea IA. The effectiveness of virtual reality based interventions for symptoms of anxiety and depression: A meta-analysis. Sci Rep. 2018 Jul 9;8(1):10323. doi: 10.1038/s41598-018-28113-6. PMID: 29985400; PMCID: PMC6037699.

[133]

Shah LB, Torres S, Kannusamy P, Chng CM, He HG, Klainin-Yobas P. Efficacy of the virtual reality-based stress management program on stress-related variables in people with mood disorders: the feasibility study. Arch Psychiatr Nurs. 2015 Feb;29(1):6-13. doi: 10.1016/j.apnu.2014.09.003. Epub 2014 Sep 10. PMID: 25634868.

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