Sarcopenia and its diagnosis

Abstract

An increased life expectancy is associated with an increased number of persons suffering from sarcopenia, as manifested by a loss of muscle mass, strength, and body functions (decreased performance) due to aging processes.

The development of sarcopenia significantly reduces the quality of life of patients and worsens the results of treatment in the event of life-threatening conditions. Unfortunately, clinicians underestimate its diagnosis and do not pay enough attention to the muscle conditions, as well as the prevention and treatment of sarcopenia.

To date, active research and search for methods for diagnosing sarcopenia and similar pathological conditions of the muscle tissue (cachexia, fatty infiltration, and inflammatory lesions of muscle tissue) are conducted. Various scales are used to detect sarcopenia at the prehospital stage. An example is the Strength, Assistance with Walking, Rising from a Chair, Climbing Stairs, and Falls questionnaire that assess the following indicators: lifting a load, walking around the room, getting out of bed, climbing the stairs, and involuntary falls. The use of scales is limited in a hospital setting; thus, instrumental diagnostic methods are more informative, particularly bioimpedance, dual-energy X-ray absorptiometry, computed tomography, and magnetic resonance imaging, but the most in demand is ultrasound imaging of the muscle tissue.

The dynamics of the severity of sarcopenia is a promising method used to assess nutritional support and rehabilitation measures in patients under intensive care.

Keywords

sarcopenia / ultrasound examination / nutritional support

References

[1] Rosenberg IH. Epidemiologic and methodologic problems in determining nutritional status of older persons. Proceedings of a conference. Albuquerque, New Mexico, October 19–21, 1988. Am J Clin Nutr. 1989;50(5 Suppl):1121–235.

[2] Rosenberg I.H. Epidemiologic and methodologic problems in determining nutritional status of older persons. Proceedings of a conference. Albuquerque, New Mexico, October 19–21, 1988 // Am J Clin Nutr. 1989. Vol. 50, N 5, Suppl. Р. 1121–1235.

[3] Anker SD, Morley JE, von Haehling S. Affiliations expand Welcome to the ICD-10 code for sarcopenia. J Cachexia Sarcopenia Muscle. 2016;7(5):512–514. doi: 10.1002/jcsm.12147

[4] Anker S.D., Morley J.E., von Haehling S. Affiliations expand Welcome to the ICD-10 code for sarcopenia // J Cachexia Sarcopenia Muscle. 2016. Vol. 7, N 5. Р. 512–514. doi: 10.1002/jcsm.12147

[5] Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412–423. doi: 10.1093/ageing/afq034

[6] Cruz-Jentoft A.J., Baeyens J.P., Bauer J.M., et al. Sarcopenia: European consensus on definition and diagnosis Report of the European Working Group on Sarcopenia in Older People // Age Ageing. 2010. Vol. 39, N 4. Р. 412–423. doi: 10.1093/ageing/afq034

[7] Scharf G, Heineke J. Finding good biomarkers for sarcopenia. J Cachexia Sarcopenia Muscle. 2012;3(3):145–148. doi: 10.1007/s13539-012-0081-7

[8] Scharf G., Heineke J. Finding good biomarkers for sarcopenia // J Cachexia Sarcopenia Muscle. 2012. Vol. 3, N 3. Р. 145–148. doi: 10.1007/s13539-012-0081-7

[9] Malmstrom TK, Morley JE. SARC-F: a simple questionnaire to rapidly diagnose sarcopenia. J Am Med Dir Assoc. 2013;14(8): 531–532. doi: 10.1016/j.jamda.2013.05.018

[10] Malmstrom T.K., Morley J.E. SARC-F: a simple questionnaire to rapidly diagnose sarcopenia // J Am Med Dir Assoc. 2013. Vol. 14, N 8. Р. 531–532. doi: 10.1016/j.jamda.2013.05.018

[11] Paris MT, Mourtzakis M, Day A, et al. Validation of bedside ultrasound of muscle layer thickness of the quadriceps in the critically ill patient (VALIDUM Study). JPEN J Parenter Enteral Nutr. 2017;41(2):171–180. doi: 10.1177/0148607116637852

[12] Paris M.T., Mourtzakis M., Day A., et al. Validation of bedside ultrasound of muscle layer thickness of the quadriceps in the critically ill patient (VALIDUM Study) // JPEN J Parenter Enteral Nutr. 2017. Vol. 41, N 2. Р. 171–180. doi: 10.1177/0148607116637852

[13] Moisey LL, Mourtzakis M, Cotton BA, et al. Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients. Crit Care. 2013;17(5):R206. doi: 10.1186/cc12901

[14] Moisey L.L., Mourtzakis M., Cotton B.A., et al. Skeletal muscle predicts ventilator-free days, ICU-free days, and mortality in elderly ICU patients // Crit Care. 2013. Vol. 17, N 5. Р. R206. doi: 10.1186/cc12901

[15] Cruz-Jentoft AJ, Bahat G, Bauer J, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48(1):16–31. doi: 10.1093/ageing/afy169

[16] Cruz-Jentoft A.J., Bahat G., Bauer J., et al. Sarcopenia: revised European consensus on definition and diagnosis // Age Ageing. 2019. Vol. 48, N 1. Р. 16–31. doi: 10.1093/ageing/afy169

[17] Pasechnik IN, Zakrevsky AI, Talyzin PA, Mazova MS. Sarcopenia: the view of an anesthesiologist-resuscitator. Kremlin medicine. Clinical Bulletin. 2021;(1):82–89. (In Russ). doi: 10.26269/zqkk-j843

[18] Пасечник И.Н., Закревский А.И., Талызин П.А., Мазова М.С. Саркопения: взгляд анестезиолога-реаниматолога // Кремлевская медицина. Клинический вестник. 2021. Т. 1. С. 82–89. doi: 10.26269/zqkk-j843

[19] Newman AB, Kupelian V, Visser M, et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort. J Gerontol A Biol Sci Med Sci. 2006;61(1):72–77. doi: 10.1093/gerona/61.1.72

[20] Newman A.B., Kupelian V., Visser M., et al. Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort // J Gerontol A Biol Sci Med Sci. 2006. Vol. 61, N 1. Р. 72–77. doi: 10.1093/gerona/61.1.72

[21] Zheng E, Shao S, Webster JG. Impedance of skeletal muscle from 1 Hz to 1 MHz. IEEE Trans Biomed Eng. 1984;31(6):477–481. doi: 10.1109/TBME.1984.325417

[22] Zheng E., Shao S., Webster J.G. Impedance of skeletal muscle from 1 Hz to 1 MHz // IEEE Trans Biomed Eng. 1984. Vol. 31, N 6. Р. 477–481. doi: 10.1109/TBME.1984.325417

[23] Boutin RD, Yao L, Canter RJ, Lenchik L. Sarcopenia: current concepts and imaging implications. AJR Am J Roentgenol. 2015; 205(3):W255–266. doi: 10.2214/AJR.15.14635

[24] Boutin R.D., Yao L., Canter R.J., Lenchik L. Sarcopenia: current concepts and imaging implications // AJR Am J Roentgenol. 2015. Vol. 205, N 3. Р. W255–266. doi: 10.2214/AJR.15.14635

[25] Bazzocchi A, Diano D, Ponti F, et al. A 360-degree overview of body composition in healthy people: relationships among anthropometry, ultrasonography, and dual-energy X-ray absorptiometry. Nutrition. 2014;30(6):696–701. doi: 10.1016/j.nut.2013.11.013

[26] Bazzocchi A., Diano D., Ponti F., et al. A 360-degree overview of body composition in healthy people: relationships among anthropometry, ultrasonography, and dual-energy X-ray absorptiometry // Nutrition. 2014. Vol. 30, N 6. Р. 696–701. doi: 10.1016/j.nut.2013.11.013

[27] Anandavadivelan P, Lagergren P. Cachexia in patients with oesophageal cancer. Nat Rev Clin Oncol. 2016;13(3):185–198. doi: 10.1038/nrclinonc.2015.200

[28] Anandavadivelan P., Lagergren P. Cachexia in patients with oesophageal cancer // Nat Rev Clin Oncol. 2016. Vol. 13, N 3. Р. 185–198. doi: 10.1038/nrclinonc.2015.200

[29] Kim KM, Jang HC, Lim S. Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia. Korean J Intern Med. 2016;31(4):643–650. doi: 10.3904/kjim.2016.015

[30] Kim K.M., Jang H.C., Lim S. Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia // Korean J Intern Med. 2016. Vol. 31, N 4. Р. 643–650. doi: 10.3904/kjim.2016.015

[31] Baumgartner RN, Koehler KM, Gallagheret D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol. 1998;147(8):755–763. doi: 10.1093/oxfordjournals.aje.a009520

[32] Baumgartner R.N., Koehler K.M., Gallagheret D., et al. Epidemiology of sarcopenia among the elderly in New Mexico // Am J Epidemiol. 1998. Vol. 147, N 8. Р. 755–763. doi: 10.1093/oxfordjournals.aje.a009520

[33] Cawthon PM, Peters KW, Shardellet MD, et al. Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness. J Gerontol A Biol Sci Med Sci. 2014;69(5): 567–575. doi: 10.1093/gerona/glu023

[34] Cawthon P.M., Peters K.W., Shardellet M.D., et al. Cutpoints for low appendicular lean mass that identify older adults with clinically significant weakness // J Gerontol A Biol Sci Med Sci. 2014. Vol. 69, N 5. Р. 567–575. doi: 10.1093/gerona/glu023

[35] Guerri S, Mercatelli D, Gómezet MP, et al. Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia. Quant Imaging Med Surg. 2018;8(1):60–85. doi: 10.21037/qims.2018.01.05

[36] Guerri S., Mercatelli D., Gómezet M.P., et al. Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia // Quant Imaging Med Surg. 2018. Vol. 8, N 1. Р. 60–85. doi: 10.21037/qims.2018.01.05

[37] Sergi G, Trevisan C, Veronese N, et al. Imaging of sarcopenia. Eur J Radiol. 2016;85(8):1519–1524. doi: 10.1016/j.ejrad.2016.04.009

[38] Sergi G., Trevisan C., Veronese N., et al. Imaging of sarcopenia // Eur J Radiol. 2016. Vol. 85, N 8. Р. 1519–1524. doi: 10.1016/j.ejrad.2016.04.009

[39] Miljkovic I, Zmuda JM. Epidemiology of myosteatosis. Curr Opin Clin Nutr Metab Care. 2010;13(3):260–264. doi: 10.1097/MCO.0b013e328337d826

[40] Miljkovic I., Zmuda J.M. Epidemiology of myosteatosis // Curr Opin Clin Nutr Metab Care. 2010. Vol. 13, N 3. Р. 260–264. doi: 10.1097/MCO.0b013e328337d826

[41] Yoon DY, Moon JH, Kim HK, et al. Comparison of low-dose CT and MR for measurement of intra-abdominal adipose tissue: a phantom and human study. Acad Radiol. 2008;15(1):62–70. doi: 10.1016/j.acra.2007.07.013

[42] Yoon D.Y., Moon J.H., Kim H.K., et al. Comparison of low-dose CT and MR for measurement of intra-abdominal adipose tissue: a phantom and human study // Acad Radiol. 2008. Vol. 15, N 1. Р. 62–70. doi: 10.1016/j.acra.2007.07.013

[43] Seabolt LA, Welch EB, Silver HJ. Imaging methods for analyzing body composition in human obesity and cardiometabolic disease. Ann N Y Acad Sci. 2015;1353:41–59. doi: 10.1111/nyas.12842

[44] Seabolt L.A., Welch E.B., Silver H.J. Imaging methods for analyzing body composition in human obesity and cardiometabolic disease // Ann N Y Acad Sci. 2015. Vol. 1353. Р. 41–59. doi: 10.1111/nyas.12842

[45] Lustgarten MS, Fielding RA. Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials. J Nutr Health Aging. 2011;15(5):368–375. doi: 10.1007/s12603-011-0049-x

[46] Lustgarten M.S., Fielding R.A. Assessment of analytical methods used to measure changes in body composition in the elderly and recommendations for their use in phase II clinical trials // J Nutr Health Aging. 2011. Vol. 15, N 5. Р. 368–375. doi: 10.1007/s12603-011-0049-x

[47] Dalakas MC. Inflammatory muscle diseases. N Engl J Med. 2015;372(18):1734–1747. doi: 10.1056/NEJMra1402225

[48] Dalakas M.C. Inflammatory muscle diseases // N Engl J Med. 2015. Vol. 372, N 18. Р. 1734–1747. doi: 10.1056/NEJMra1402225

[49] Erlandson MC, Lorbergs AL, Mathur S, Cheung AM. Muscle analysis using pQCT, DXA and MRI. Eur J Radiol. 2016;85(8): 1505–1511. doi: 10.1016/j.ejrad.2016.03.001

[50] Erlandson M.C., Lorbergs A.L., Mathur S., Cheung A.M. Muscle analysis using pQCT, DXA and MRI // Eur J Radiol. 2016. Vol. 85, N 8. Р. 1505–1511. doi: 10.1016/j.ejrad.2016.03.001

[51] Prado CM, Lieffers JR, McCargaret LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008;9(7):629–635. doi: 10.1016/S1470-2045(08)70153-0

[52] Prado C.M., Lieffers J.R., McCargaret L.J., et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study // Lancet Oncol. 2008. Vol. 9, N 7. Р. 629–635. doi: 10.1016/S1470-2045(08)70153-0

[53] Martin L, Birdsell L, Macdonaldet N, et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index. J Clin Oncol. 2013;31(12):1539–1547. doi: 10.1200/JCO.2012.45.2722

[54] Martin L., Birdsell L., Macdonaldet N., et al. Cancer cachexia in the age of obesity: skeletal muscle depletion is a powerful prognostic factor, independent of body mass index // J Clin Oncol. 2013. Vol. 31, N 12. Р. 1539–1547. doi: 10.1200/JCO.2012.45.2722

[55] Morrell GR, Ikizler TA, Chenet X, et al. Psoas muscle cross-sectional area as a measure of whole-body lean muscle mass in maintenance hemodialysis patients. J Ren Nutr. 2016;26(4):258–264. doi: 10.1053/j.jrn.2016.02.002

[56] Morrell G.R., Ikizler T.A., Chenet X., et al. Psoas muscle cross-sectional area as a measure of whole-body lean muscle mass in maintenance hemodialysis patients // J Ren Nutr. 2016. Vol. 26, N 4. Р. 258–264. doi: 10.1053/j.jrn.2016.02.002

[57] Noumura Y, Kamishima T, Sutherland K, Nishimura H. Visceral adipose tissue area measurement at a single level: can it represent visceral adipose tissue volume? Br J Radiol. 2017;90(1077):20170253. doi: 10.1259/bjr.20170253

[58] Noumura Y., Kamishima T., Sutherland K., Nishimura H. Visceral adipose tissue area measurement at a single level: can it represent visceral adipose tissue volume? // Br J Radiol. 2017. Vol. 90, N 1077. Р. 20170253. doi: 10.1259/bjr.20170253

[59] Schweitzer L, Geisler C, Pourhassanet M. What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults? Am J Clin Nutr. 2015;102(1):58–65. doi: 10.3945/ajcn.115.111203

[60] Schweitzer L., Geisler C., Pourhassanet M. What is the best reference site for a single MRI slice to assess whole-body skeletal muscle and adipose tissue volumes in healthy adults? // Am J Clin Nutr. 2015. Vol. 102, N 1. Р. 58–65. doi: 10.3945/ajcn.115.111203

[61] Yip C, Dinkel C, Mahajanet A, et al. Imaging body composition in cancer patients: visceral obesity, sarcopenia and sarcopenic obesity may impact on clinical outcome. Insights Imaging. 2015;6(4): 489–497. doi: 10.1007/s13244-015-0414-0

[62] Yip C., Dinkel C., Mahajanet A., et al. Imaging body composition in cancer patients: visceral obesity, sarcopenia and sarcopenic obesity may impact on clinical outcome // Insights Imaging. 2015. Vol. 6, N 4. Р. 489–497. doi: 10.1007/s13244-015-0414-0

[63] Schweitzer L, Geisler C, Pourhassanet M, et al. Estimation of skeletal muscle mass and visceral adipose tissue volume by a single magnetic resonance imaging slice in healthy elderly adults. J Nutr. 2016;146(10):2143–2148. doi: 10.3945/jn.116.236844

[64] Schweitzer L., Geisler C., Pourhassanet M., et al. Estimation of skeletal muscle mass and visceral adipose tissue volume by a single magnetic resonance imaging slice in healthy elderly adults // J Nutr. 2016. Vol. 146, N 10. Р. 2143–2148. doi: 10.3945/jn.116.236844

[65] Tosato M, Marzetti E, Cesaril M, et al. Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging Clin Exp Res. 2017;29(1):19–27. doi: 10.1007/s40520-016-0717-0

[66] Tosato M., Marzetti E., Cesaril M. et al. Measurement of muscle mass in sarcopenia: from imaging to biochemical markers // Aging Clin Exp Res. 2017. Vol. 29, N 1. Р. 19–27. doi: 10.1007/s40520-016-0717-0

[67] Heckmatt JZ, Dubowitz V, Leeman S. Detection of pathological change in dystrophic muscle with B-scan ultrasound imaging. Lancet. 1980;1(8183):1389–1390. doi: 10.1016/s0140-6736(80)92656-2

[68] Heckmatt J.Z., Dubowitz V., Leeman S. Detection of pathological change in dystrophic muscle with B-scan ultrasound imaging // Lancet. 1980. Vol. 1, N 8183. Р. 1389–1390. doi: 10.1016/s0140-6736(80)92656-2

[69] Heckmatt JZ, Leeman S, Dubowitz V. Ultrasound imaging in the diagnosis of muscle disease. J Pediatr. 1982;101(5):656–660. doi: 10.1016/s0022-3476(82)80286-2

[70] Heckmatt J.Z., Leeman S., Dubowitz V. Ultrasound imaging in the diagnosis of muscle disease // J Pediatr. 1982. Vol. 101, N 5. Р. 656–660. doi: 10.1016/s0022-3476(82)80286-2

[71] Pillen S. Skeletal muscle ultrasound. Europ J Translational Myology. 2010;20(4):145–155. doi: 10.4081/ejtm.2010.1812

[72] Pillen S. Skeletal muscle ultrasound // Europ J Translational Myology. 2010. Vol. 20, N 4. Р. 145–155. doi: 10.4081/ejtm.2010.1812

[73] Ticinesi A, Meschi T, Nariciet MV, et al. Muscle ultrasound and sarcopenia in older individuals: a clinical perspective. J Am Med Dir Assoc. 2017;18(4):290–300. doi: 10.1016/j.jamda.2016.11.013

[74] Ticinesi A., Meschi T., Nariciet M.V., et al. Muscle ultrasound and sarcopenia in older individuals: a clinical perspective // J Am Med Dir Assoc. 2017. Vol. 18, N 4. Р. 290–300. doi: 10.1016/j.jamda.2016.11.013

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Zakrevsky A.I., Fedorova A.A., Pasechnik I.N., Kutepov D.E.