Efficacy of a short course of intensive therapy with TGF-β2-enriched enteral nutrition for severe gastrointestinal toxicity: a case report
Olga A. Obukhova , Ildar A. Kurmukov , Grigory S. Yunaev
Clinical nutrition and metabolism ›› 2024, Vol. 5 ›› Issue (2) : 86 -92.
Efficacy of a short course of intensive therapy with TGF-β2-enriched enteral nutrition for severe gastrointestinal toxicity: a case report
Background: Timely and successful treatment of chemotherapy-induced gastrointestinal toxicity ensures continued antitumor therapy in patients with cancer. Severe diarrhea can lead to dehydration and refusal of further cytostatic treatment. We present a clinical case of severe gastrointestinal toxicity requiring complex intensive therapy.
Case description: A 63-year-old male diagnosed with stage IV infiltrative ascending colon cancer with multiple liver metastases, T3N1M1, underwent four cycles of antitumor therapy following the FOLFOXIRI regimen (oxaliplatin, irinotecan, leucovorin, 5-fluorouracil) combined with bevacizumab, which was later discontinued due to thrombotic events. After the fifth cycle of FOLFOXIRI chemotherapy, grade 3 diarrhea developed, leading to dehydration and requiring complex intensive therapy, including TGF-β2-enriched enteral nutrition. The intervention was successful, enabling timely continuation of chemotherapy.
Conclusion: Considering the pathophysiology of drug-induced diarrhea, additional outpatient TGF-β2-enriched enteral nutrition should be recommended. This approach may reduce systemic disorders and aid in the prevention and rapid resolution of intestinal toxicity.
chemotherapy / gastrointestinal toxicity / case report / TGF-β2-enriched enteral nutrition
Eco-Vector
/
| 〈 |
|
〉 |
PDF
