Myocardial infarction type 2 and myocardial injury: The current state of the problem

Abstract

Today, the most difficult in terms of diagnosis and treatment today among various types of myocardial infarction (MI) is MI type 2 (MI-2). The lack of clinical guidelines for management of patients with this type of MI, as well as the literature data on prevalence, patient characteristics and prognosis contributes to the scientific relevance of the further research.

Keywords

myocardial infarction type 2 / myocardial injury

References

[1] Thygesen K, Alpert JS, White HD, et al. Universal definition of myocardial infarction. Eur Heart J. 2007;28(20):2525–2538. DOI: 10.1093/eurheartj/ehm355

[2] Thygesen K., Alpert J.S., White H.D. Universal definition of myocardial infarction // Eur. Heart J. 2007. Vol. 28, No. 20. P. 2525–2538. DOI: 10.1093/eurheartj/ehm355

[3] Sandoval Y, Thygesen K. Myocardial infarction type 2 and myocardial injury. Clin Chem. 2017;63(1):101–107. DOI: 10.1373/clinchem.2016.255521

[4] Sandoval Y., Thygesen K. Myocardial infarction type 2 and myocardial injury // Clin. Chem. 2017. Vol. 63, No. 1. P. 101–107. DOI: 10.1373/clinchem.2016.255521

[5] Zhelnov VV, Dyatlov NV, Dvoretskiy LI. Myocardial infarction type 2: myth or reality? Arkhiv vnutrenney meditsiny. 2016;6(2(28)):34–41. DOI: 10.20514/2226-6704-2016-6-2-34-41

[6] Желнов В.В., Дятлов Н.В., Дворецкий Л.И. Инфаркт миокарда второго типа. Миф или реальность? // Архивъ внутренней медицины. 2016. Т. 6, № 2(28). С. 34–41.

[7] Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction. Russian Journal of Cardiology. 2019;24(3):107–138. DOI: 10.15829/1560-4071-2019-3-107-138

[8] Thygesen K., Alpert J.S., Jaffe A.S. et al. Fourth universal definition of myocardial infarction // Circulation. 2018. Vol. 138, No. 20. P. e618–e651. DOI: 10.1161/CIR.0000000000000617

[9] Mihatov N, Januzzi JL Jr, Gaggin HK. Type 2 myocardial infarction due to supply-demand mismatch. Trends Cardiovasc Med. 2017;27(6):408–417. DOI: 10.1016/j.tcm.2017.03.002

[10] Mihatov N., Januzzi J.L.Jr., Gaggin H.K. Type 2 myocardial infarction due to supply-demand mismatch // Trends. Cardiovasc. Med. 2017. Vol. 27, No. 6. P. 408–417. DOI: 10.1016/j.tcm.2017.03.002

[11] Smilowitz NR, Weiss MC, Mauricio R, et al. Provoking conditions, management and outcomes of type 2 myocardial infarction and myocardial necrosis. Int J Cardiol. 2016;218:196–201. DOI: 10.1016/j.ijcard.2016.05.045

[12] Smilowitz N.R., Weiss M.C., Mauricio R. et al. Provoking conditions, management and outcomes of type 2 myocardial infarction and myocardial necrosis // Int. J. Cardiol. 2016. Vol. 218. P. 196–201. DOI: 10.1016/j.ijcard.2016.05.045

[13] Kuznetsova OYu, Dubikaitis TA, Frolova EV, et al. he classification of acute myocardial infarction types and the preconditions for its development. Type II myocardial infarction. Russian family doctor. 2017;21(3):5–15. (In Russ.). DOI: 10.17816/RFD201735-15

[14] Кузнецова О.Ю., Дубикайтис Т.А., Фролова Е.В. и др. Классификация типов инфаркта миокарда и предпосылки для ее создания. Инфаркт миокарда 2-го типа // Российский семейный врач. 2017. Т. 21, № 3. С. 5–15. DOI: 10.17816/RFD201735-15

[15] Agewall S, Giannitsis E, Jernberg T, Katus H. Troponin elevation in coronary vs. non-coronary disease. Eur Heart J. 2011;32(4):404–411. DOI: 10.1093/eurheartj/ehq456

[16] Agewall S., Giannitsis E., Jernberg T., Katus H. Troponin elevation in coronary vs. non-coronary disease // Eur. Heart J. 2011. Vol. 32, No. 4. P. 404–411. DOI: 10.1093/eurheartj/ehq456

[17] Masri W, Le Guillou E, Hamdi E, et al. Troponin elevation in other conditions than acute coronary syndromes. Ann Biol Clin (Paris). 2017;75(4):411–419. DOI: 10.1684/abc.2017.1262

[18] Masri W., Le Guillou E., Hamdi E. et al. Troponin elevation in other conditions than acute coronary syndromes // Ann. Biol. Clin. (Paris). 2017. Vol. 75, No. 4. P. 411–419. DOI: 10.1684/abc.2017.1262

[19] Eggers KM, Lindahl B. application of cardiac troponin in cardiovascular diseases other than acute coronary syndrome. Clin Chem. 2017;63(1):223–235. DOI: 10.1373/clinchem.2016.261495

[20] Eggers K.M., Lindahl B. application of cardiac troponin in cardiovascular diseases other than acute coronary syndrome // Clin. Chem. 2017. Vol. 63, No. 1. P. 223–235. DOI: 10.1373/clinchem.2016.261495

[21] Sarkisian L, Saaby L, Poulsen TS, et al. Clinical characteristics and outcomes of patients with myocardial infarction, myocardial injury, and nonelevated troponins. Am J Med. 2016;129(4):446e.5–446e.21. DOI: 10.1016/j.amjmed.2015.11.006

[22] Sarkisian L., Saaby L., Poulsen T.S. et al. Clinical characteristics and outcomes of patients with myocardial infarction, myocardial injury, and nonelevated troponins // Am. J. Med. 2016. Vol. 129, No. 4. P. 446e.5–446e.21. DOI: 10.1016/j.amjmed.2015.11.006

[23] Brinkmann C, Schofer J. 4th universal definition of myocardial infarction 2018: What is new? Herz. 2018;43(8):681–688. DOI: 10.1007/s00059-018-4763-6. (In German)

[24] Brinkmann C., Schofer J. 4th universal definition of myocardial infarction 2018: What is new? // Herz. 2018. Vol. 43, No. 8. P. 681–688. DOI: 10.1007/s00059-018-4763-6. (In German)

[25] Chapman AR, Shah ASV, Lee KK, et al. Long-term outcomes in patients with type 2 myocardial infarction and myocardial injury. Circulation. 2018;137(12):1236–1245. DOI: 10.1161/circulationaha.117.031806

[26] Chapman A.R., Shah A.S.V., Lee K.K. et al. Long-term outcomes in patients with type 2 myocardial infarction and myocardial injury // Circulation. 2018. Vol. 137, No. 12. P. 1236–1245. DOI: 10.1161/circulationaha.117.031806

[27] Saaby L, Poulsen TS, Hosbond S, et al. Classification of myocardial infarction: frequency and features of type 2 myocardial infarction. Am J Med. 2013;126(9):789–797. DOI: 10.1016/j.amjmed.2013.02.029

[28] Saaby L., Poulsen T.S., Hosbond S. et al. Classification of myocardial infarction: frequency and features of type 2 myocardial infarction // Am. J. Med. 2013. Vol. 126, No. 9. P. 789–797. DOI: 10.1016/j.amjmed.2013.02.029

[29] Stein GY, Herscovici G, Korenfeld R, et al. Type-II myocardial infarction – patient characteristics, management and outcomes. PLoS One. 2014;9(1):e84285. DOI: 10.1371/journal.pone.0084285

[30] Stein G.Y., Herscovici G., Korenfeld R. et al. Type-II myocardial infarction – patient characteristics, management and outcomes // PLoS One. 2014. Vol. 9, No. 1. P. e84285. DOI: 10.1371/journal.pone.0084285

[31] Greenslade JH, Adikari T, Mueller C, et al. Characteristics and occurrence of type 2 myocardial infarction in emergency department patients: a prospective study. Emerg Med J. 2018;35(3):169–175. DOI: 10.1136/emermed-2017-206869

[32] Greenslade J.H., Adikari T., Mueller C. et al. Characteristics and occurrence of type 2 myocardial infarction in emergency department patients: a prospective study // Emerg. Med. J. 2018. Vol. 35, No. 3. P. 169–175. DOI: 10.1136/emermed-2017-206869

[33] McCarthy CP, Murphy S, Cohen JA, et al. Sex differences in patient characteristics, treatment strategies, and outcomes for type 2 myocardial infarction . J Am Coll Cardiol. 2019;(73)24:3230–3233. DOI: 10.1016/j.jacc.2019.04.016

[34] McCarthy C.P., Murphy S., Cohen J.A. et al. Sex differences in patient characteristics, treatment strategies, and outcomes for type 2 myocardial infarction // J. Am. Coll. Cardiol. 2019. Vol. 73, No. 24. P. 3230–3233. DOI: 10.1016/j.jacc.2019.04.016

[35] Chapman AR, Adamson PD, Mills NL. Assessment and classification of patients with myocardial injury and infarction in clinical practice. Heart. 2017;103(1):10–18. DOI: 10.1136/heartjnl-2016-309530

[36] Chapman A.R., Adamson P.D., Mills N.L. Assessment and classification of patients with myocardial injury and infarction in clinical practice // Heart. 2017. Vol. 103, No. 1. P. 10–18. DOI: 10.1136/heartjnl-2016-309530

[37] Melberg T, Burman R, Dickstein K. The impact of the 2007 ESC-ACC-AHA-WHF Universal definition on the incidence and classification of acute myocardial infarction: a retrospective cohort study. Int J Cardiol. 2010;139(3):228–233. DOI: 10.1016/j.ijcard.2008.10.021

[38] Melberg T., Burman R., Dickstein K. The impact of the 2007 ESC-ACC-AHA-WHF Universal definition on the incidence and classification of acute myocardial infarction: a retrospective cohort study // Int. J. Cardiol. 2010. Vol. 139, No. 3. P. 228–233. DOI: 10.1016/j.ijcard.2008.10.021

[39] McCarthy CP, Vaduganathan M, Januzzi JL Jr. Type 2 Myocardial infarction-diagnosis, prognosis, and treatment. JAMA. 2018;320(5):433–434. DOI:10.1001/jama.2018.7125

[40] McCarthy C.P., Vaduganathan M., Januzzi J.L.Jr. Type 2 myocardial infarction-diagnosis, prognosis, and treatment // JAMA. 2018. Vol. 320, No. 5. P. 433–434. DOI: 10.1001/jama.2018.7125

[41] Zharskiy SL. Type 2 Myocardial Infarction: the current state of the problem. Far East Medical Journal. 2016;3:134–138. (In Russ.)

[42] Жарский С.Л. Инфаркт миокарда 2 типа: современное состояние проблемы // Дальневосточный медицинский журнал. 2016. Т. 3. С. 134–138.

[43] Neumann JT, Sörensen NA, Rübsamen N, et al. Discrimination of patients with type 2 myocardial infarction. Eur Heart J. 2017;38(47):3514–3520. DOI: 10.1093/eurheartj/ehx457

[44] Neumann J.T., Sörensen N.A., Rübsamen N. et al. Discrimination of patients with type 2 myocardial infarction // Eur. Heart J. 2017. Vol. 38, No. 47. P. 3514–3520. DOI: 10.1093/eurheartj/ehx457

[45] Collinson P, Lindahl B. Type 2 myocardial infarction: the chimaera of cardiology? Heart. 2015;101(21):1697–1703. DOI: 10.1136/heartjnl-2014-307122

[46] Collinson P., Lindahl B. Type 2 myocardial infarction: the chimaera of cardiology? // Heart. 2015. Vol. 101, No. 21. P. 1697–1703. DOI: 10.1136/heartjnl-2014-307122

[47] Spatz ES, Curry LA, Masoudi FA, et al. The variation in recovery: role of gender on outcomes of young AMI patients (VIRGO) classification system: a taxonomy for young women with acute myocardial infarction. Circulation. 2015;132(18):1710–1718. DOI: 10.1161/CIRCULATIONAHA.115.016502

[48] Spatz E.S., Curry L.A., Masoudi F.A. et al. The variation in recovery: role of gender on outcomes of young AMI patients (VIRGO) classification system: a taxonomy for young women with acute myocardial infarction // Circulation 2015. Vol. 132, No. 18. P. 1710–1718. DOI: 10.1161/CIRCULATIONAHA.115.016502

[49] Arora S, Cavender MA, Chang PP. Outcomes of decreasing versus increasing cardiac troponin in patients admitted with non-ST-segment elevation myocardial infarction: the atherosclerosis risk in communities surveillance study. Eur Heart J Acute Cardiovasc Care. 2019:2048872619842983. DOI: 10.1177/2048872619842983. Online ahead of print.

[50] Arora S., Cavender M.A., Chang P.P. Outcomes of decreasing versus increasing cardiac troponin in patients admitted with non-ST-segment elevation myocardial infarction: the Atherosclerosis Risk in Communities Surveillance Study // Eur. Heart J. Acute Cardiovasc. Care. 2019:2048872619842983. DOI: 10.1177/2048872619842983. Online ahead of print.

[51] Sandoval Y, Smith SW, Sexter A, et al. Use of objective evidence of myocardial ischemia to facilitate the diagnostic and prognostic distinction between type 2 myocardial infarction and myocardial injury. Eur Heart J Acute Cardiovasc Care. 2020;9(1):62–69. DOI: 10.1177/2048872618787796

[52] Sandoval Y., Smith S.W., Sexter A. et al. Use of objective evidence of myocardial ischemia to facilitate the diagnostic and prognostic distinction between type 2 myocardial infarction and myocardial injury // Eur. Heart J. Acute Cardiovasc. Care. 2020. Vol. 9, No. 1. P. 62–69. DOI: 10.1177/2048872618787796

[53] Kolodgie FD, Virmani R, Finn AV, Romero ME. Embolic myocardial infarction as a consequence of atrial fibrillation: a prevailing disease of the future. Circulation. 2015;132(4):223–226. DOI: 10.1161/CIRCULATIONAHA.115.017534

[54] Kolodgie F.D., Virmani R., Finn A.V., Romero M.E. Embolic myocardial infarction as a consequence of atrial fibrillation: a prevailing disease of the future // Circulation. 2015. Vol. 132, No. 4. P. 223–226. DOI: 10.1161/CIRCULATIONAHA.115.017534

[55] Sandoval Y, Smith SW, Thordsen SE, Apple FS. Supply/demand type 2 myocardial infarction: should we be paying more attention? J Am Coll Cardiol. 2014;63(20):2079–2087. DOI: 10.1016/j.jacc.2014.02.541

[56] Sandoval Y., Smith S.W., Thordsen S.E., Apple F.S. Supply/demand type 2 myocardial infarction: should we be paying more attention? // J. Am. Coll. Cardiol. 2014. Vol. 63, No. 20. P. 2079–2087. DOI: 10.1016/j.jacc.2014.02.541

[57] Agewall S, Beltrame JF, Reynolds HR, et al. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries. Eur Heart J. 2017;38(3):143–153. DOI: 10.1093/eurheartj/ehw149

[58] Agewall S., Beltrame J.F., Reynolds H.R. et al. ESC working group position paper on myocardial infarction with non-obstructive coronary arteries // Eur. Heart J. 2017. Vol. 38, No. 3. P. 143–153. DOI: 10.1093/eurheartj/ehw149

[59] Niccoli G, Scalone G, Crea F. Acutemyocardial infarction with no obstructive coronary atherosclerosis: mechanisms and management. Eur Heart J. 2015;36(8):475–481. DOI: 10.1093/eurheartj/ehu469

[60] Niccoli G., Scalone G., Crea F. Acutemyocardial infarction with no obstructive coronary atherosclerosis: mechanisms and management // Eur. Heart J. 2015. Vol. 36, No. 8. P. 475–481. DOI: 10.1093/eurheartj/ehu469

[61] Alpert JS, Thygesen KA, White HD, Jaffe AS. Diagnostic and therapeutic implications of type 2 myocardial infarction: review and commentary. Am J Med. 2014;127(2):105–108. DOI: 10.1016/j.amjmed.2013.09.031

[62] Alpert J.S., Thygesen K.A., White H.D., Jaffe A.S. Diagnostic and therapeutic implications of type 2 myocardial infarction: review and commentary // Am. J. Med. 2014. Vol. 127, No. 2. P. 105–108. DOI: 10.1016/j.amjmed.2013.09.031

[63] Nestelberger T, Boeddinghaus J, Badertscher P, et al. Effect of definition on incidence and prognosis of type 2 myocardial infarction. J Am Coll Cardiol. 2017;70(13):1558–1568. DOI: 10.1016/j.jacc.2017.07.774

[64] Nestelberger T., Boeddinghaus J., Badertscher P. et al. Effect of definition on incidence and prognosis of type 2 myocardial infarction // J. Am. Coll. Cardiol. 2017. Vol. 70, No. 13. P. 1558–1568. DOI: 10.1016/j.jacc.2017.07.774

[65] Thygesen K, Jaffe AS. Detecting myocardial infarction type 2: targetting the right patients. Eur Heart J. 2017;38(47):3521–3522. DOI: 10.1093/eurheartj/ehx557

[66] Thygesen K., Jaffe A.S. Detecting myocardial infarction type 2: targetting the right patients // Eur. Heart J. 2017. Vol. 38, No. 47. P. 3521–3522. DOI: 10.1093/eurheartj/ehx557

[67] Radovanovic D, Pilgrim T, Seifert B, et al. Type 2 myocardial infarction: incidence, presentation, treatment and outcome in routine clinical practice. J Cardiovasc Med (Hagerstown). 2017;18(5):341–347. DOI: 10.2459/JCM.0000000000000504

[68] Radovanovic D., Pilgrim T., Seifert B. et al. Type 2 myocardial infarction: incidence, presentation, treatment and outcome in routine clinical practice // J. Cardiovasc. Med. (Hagerstown). 2017. Vol. 18, No. 5. P. 341–347. DOI: 10.2459/JCM.0000000000000504

[69] Smilowitz NR, Subramanyam P, Gianos E, et al. Treatment and outcomes of type 2 myocardial infarction and myocardial injury compared with type 1 myocardial infarction. Coron Artery Dis. 2018;29(1):46–52. DOI: 10.1097/MCA.0000000000000545

[70] Smilowitz N.R., Subramanyam P., Gianos E. et al. Treatment and outcomes of type 2 myocardial infarction and myocardial injury compared with type 1 myocardial infarction // Coron. Artery Dis. 2018. Vol. 29, No. 1. P. 46–52. DOI: 10.1097/MCA.0000000000000545

[71] Cediel G, Sandoval Y, Sexter A, et al. Risk estimation in type 2 myocardial infarction and myocardial injury: the tarraco risk score. Am J Med. 2019;132(2):217–226. DOI: 10.1016/j.amjmed.2018.10.022

[72] Cediel G., Sandoval Y., Sexter A. et al. Risk estimation in type 2 myocardial infarction and myocardial injury: the tarraco risk score // Am. J. Med. 2019. Vol. 132, No. 2. P. 217–226. DOI: 10.1016/j.amjmed.2018.10.022

[73] Cediel G, Gonzalez-Del-Hoyo M, Carrasquer A, et al. Outcomes with type 2 myocardial infarction compared with non-ischaemic myocardial injury. Heart. 2017;103(8):616–622. DOI: 10.1136/heartjnl-2016-310243

[74] Cediel G., Gonzalez-Del-Hoyo M., Carrasquer A. et al. Outcomes with type 2 myocardial infarction compared with non-ischaemic myocardial injury // Heart. 2017. Vol. 103, No. 8. P. 616–622. DOI: 10.1136/heartjnl-2016-310243

[75] Lambrecht S, Sarkisian L, Saaby L, et al. Different causes of death in patients with myocardial infarction type 1, type 2, and myocardial injury. Am J Med. 2018;131(5):548–554. DOI: 10.1016/j.amjmed.2017.11.043

[76] Lambrecht S., Sarkisian L., Saaby L. et al. Different causes of death in patients with myocardial infarction type 1, type 2, and myocardial injury // Am. J. Med. 2018. Vol. 131, No. 5. P. 548–554. DOI: 10.1016/j.amjmed.2017.11.043

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