Fever-induced epileptic encephalopathy in children (FIRES)

Abstract

Fever infection-related epilepticy syndrome, FIRES — rare severe epileptic encephalopathy infection or fever-induced refractory epileptic status developing in a previously healthy child. The etiology of FIRES remains unknown; post-inflammatory and autoimmune mechanisms are assumed. Recovery is possible, but the majority of children develop significant cognitive failure and refractory epilepsy.

Keywords

malignant epileptic encephalopathy / fever / children

References

[1] Бобылова М.Ю. Резистентные формы эпилепсии, ассоциированные с фебрильно провоцируемыми приступами (синдромы Драве, DESCV, HHE) (лекция) // Русский журнал детской неврологии. – 2012. – Т. VII. – № 4. – С. 31–40. [Bobylоvа MY. Resistant epilepsy forms, associated with fever-provoked (febrile) epileptic seizures (Dravet syndrome, DESCV, HHE) (lecture). Russian Journal of Child Neurology. 2012;7(4):31-40. (In Russ.)]. https://doi.org/10.17650/2073-8803-2012-7-4-31-40.

[2] Шалькевич Л.В., Львова О.А., Кудлач А.И., Комир В.В. Особенности и характер течения у детей синдрома эпилепсии, индуцированного фебрильной инфекцией (FIRES) // Неврология, нейропсихиатрия, психосоматика. – 2014. – Т. 6. – № 4. – С. 65–71. [Shalkevich LV, Lvova OA, Kudlach AI, Komir VV. The specific features and pattern of febrile infection-related epilepsy syndrome (FIRES) in children. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(4):65-71. (In Russ.)]. https://doi.org/10.14412/2074-2711-2014-4-65-71.

[3] Andreas Van Baalen, Martin Häusler, Rainer Boor, et al. Febrile infection–related epilepsy syndrome (FIRES): а nonencephalitic encephalopathy in childhood. Epilepsia. 2010;51(7):1323-1328. https://doi.org/10.1111/j.1528- 1167.2010.02535.x.

[4] Lyon G, Dodge PR, Adams RD. The acute encephalopathies of obscure origin in infants and children. Brain. 1961;84(4):680-708. https://doi.org/10.1093/brain/84.4.680.

[5] Hington GG. Postnatal organic causes of mental retardation. Canad Med Ass J. 1962;87(9):501-507.

[6] Baxter P, Clarke A, Cross H, et al. Idiopathic catastrophic epileptic encephalopathy presenting with acute onset intractable status. Seizure. 2003;12(6):379-87. https://doi.org/10.1016/S1059-1311(02)00340-0.

[7] Mikaeloff Y, Jambaquе I, Hertz-Pannier L, et al. Devastating epileptic encephalopathy in school-aged children (DESC): a pseudo encephalitis. Epilepsy Res. 2006;69:67-69. https://doi.org/10.1016/j.eplep- syres.2006.01.002.

[8] Sakuma H, Awaya Y, Shiomi M, et al. Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis. Acta Neurol Scand. 2010;121(4):251-6. https://doi.org/10.1111/j.1600-0404.2009.01198.x.

[9] Sakuma H, Fukumizu M, Kohyama J. Efficacy of anticonvulsants on acute encephalitis with refractory, repetitive partial seizures (AERRPS). No To Hattatsu. 2001;33(5):385-90.

[10] Kramer U, Shorer Z, Ben-Zeev B, et al. Severe refractory status epilepticus owing to presumedencephalitis. J Child Neurol. 2005;20(3):184-7. https://doi.org/10.1177/08830738050200030301.

[11] Мухин К.Ю., Петрухин А.С., Холин А.А. Эпилептические энцефалопатии и схожие синдромы у детей. – М.: АртСервис Лтд, 2011. – 680 с. [Mukhin KY, Petrukhin AS, Kholin AА. Epileptic encephalopathies and similar syndromes at children. Moscow: ArtServis Ltd; 2011. 680 р. (In Russ.)]

[12] Wilder-Smith E, Lim E, Teoh H, et al. The NORSE (New-onset Refractory Status Epilepticus) Syndrome: Defining a Disease Entity. Ann Acad Med Singapore. 2005;34:417-20.

[13] Nabbout R. FIRES and IHHE: Delineation of the syndromes. Epilepsia. 2013;54(6):54-6. https://doi.org/10.1111/epi.12278.

[14] Sahin M, Menache CC, Holmes GL, Riviello JJ. Outcome of severe refractory status epilepticus in children. Epilepsia. 2001;42(11):1461-7. https://doi.org/10.1046/j.1528-1157.2001.21301.x.

[15] Caraballo RH, Reyes G, Lopez Avaria MF, et al. Febrile infection-related epilepsy syndrome: a study of 12 patients. Seizure. 2013;22(7):553-9. https://doi.org/10.1016/j.seizure.2013.04.005.

[16] Maegaki Y, Kondo A, Okamoto R, et al. Clinical characteristics of acute encephalopathy of obscure origin: a biphasic clinical course is a common feature. Neuropediatrics. 2006;37:269-277. https://doi.org/10.1055/s-2006-955928.

[17] Kramer U, Chi CS, Lin KL, et al. Febrile infection-related epilepsy syndrome (FIRES): pathogenesis, treatment, and outcome: a multicenter study on 77 children. Epilepsia. 2011;52(11):1956-65. https://doi.org/10.1111/j.1528-1167.2011.03250.x.

[18] Евтушенко С.К. Разрушительные и труднокурабельные формы эпилепсии и эпилептические энцефалопатии у детей // Международный неврологический журнал. – 2012. – № 6 (52). – С. 15–26. [Evtushenko SK. Destructive and difficult-to-treat epileptic forms and epileptic encephalopathies in children. Mezhdunarodnyi nevrologicheskii zhurnal. 2012;6(52):15-26. (In Russ.)]

[19] Specchio N, Fusco L, Claps D, Vigevano F. Epileptic encephalopathy in children possibly related to immune-mediated pathogenesis. Brain Dev. 2010;32(1):51-56. https://doi.org/10.1016/j.braindev.2009.09.017.

[20] Perumpillichira Cherian, Katherine Nickels. Febrile infection-related epilepsy syndromes and their treatment. Journal of Pediatric Epilepsy. 2014;3:67-74. https://doi.org/10.3233/PEP-14074.

[21] Харитонов В.И. Новое в эпилептологии // Нейро News: психоневрология и нейропсихиатрия. – 2013. – № 7(52). – С. 10–11. [Kharitonov VI. New in an epileptologiya. Neiro News: psikhonevrologiya i neiropsikhiatriya. 2013;7(52):10-11. (In Russ.)]

[22] Kim DW, Kim KK, Chu K, Lee SK. Surgical treatment of delayed epilepsy in hemiconvulsion-hemiplegiaepilepsy syndrome. Neurology. 2008;70(22 Pt 2):2116-22. https://doi.org/10.1212/01.wnl.0000289192.50924.93.

RIGHTS & PERMISSIONS

Sсhugareva L.M., Poteshkina O.V., Kruchina M.K., Rusak M.A.