Transcutaneous oxegen measurement in the area of soft tissue radiation-induced fibrosis in patients with breast cancer

Abstract

Late radiation injury in the form of radiation-induced fibrosis is one of the many complications of radiation therapy. In current literature, pathogenesis of radiation-induced fibrosis is considered from several angles. According to one of the hypotheses, the main cause of pathogenesis of radiation-induced fibrosis is damage of the blood vessels caused by radiation. Another hypothesis insists that radiation causes depletion of specific cell populations in the irradiated area, reducing the number of stem cells (mostly, fibroblasts).

Based on our first-hand experience in treating late radiation injures of soft tissues in patients with breast cancer, we measured oxygen perfusion of the skin (TсPО2) in the area of late radiation injury using a transcutaneous monitor TCM 400 (Radiometer, Denmark). The obtained results may give a new insight into pathogenesis of late radiation injures.

Keywords

late radiation injury / radiation-induced fibrosis of the skin / oxygen perfusion of the skin / breast cancer

References

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RIGHTS & PERMISSIONS

Topuzov E.E., Agishev T.T., Fedorov K.A., Krasnozhon D.A., Vats A.B., Romanovsky D.V., Dashyan G.A., Sidikov A.A., Ovsyannikov A.A., Sadygova S.N., Prikhod’ko E.V., Kasyanova M.H.