CHARACTERISTICS OF METABOLISM OF GLUCOCORTICOID HORMONESIN PATIENTS WITH PHEOCHROMOCYTOMA

M A Ivanushko; N V Vorokhobina; L I Velikanova; Z R Shafigullina

doi:10.17816/mechnikov20179359-64

HERALD of North-Western State Medical University named after I.I. Mechnikov ›› 2017, Vol. 9 ›› Issue (3) :59 -64. DOI: 10.17816/mechnikov20179359-64

Reviews

research-article

CHARACTERISTICS OF METABOLISM OF GLUCOCORTICOID HORMONESIN PATIENTS WITH PHEOCHROMOCYTOMA

Author information +

History +

PDF

Abstract

The article performs analysis of glucocorticoid hormones data and their metabolites in- vestigated by methods of high-performance liquid chromatography and gas chromatography - mass- spectrometry in 47 patients with pheochromocytoma (РНЕО) and 28 patients with hormone-inactive adenoma of the adrenal cortex. We revealed increased blood levels оf biologically active glucocorticoids and elevation of urine excretion of their tetrahydrometabolites in patients with PHEO. 6 patients with PHEO showed biochemical signs of the autonomous cortisol production. A positive correlation of free normetanephrine excretion with blood cortisol, corticosterone and 11-deoxycortisol and urine excretion of tetrahydrometabolites and cortols and a negative correlation with the urine excretion of tetrahydro-11-dehydrocorticosterone were detected. An increase of the THF/THE and (THF+alloTHF+cortol)/ (THE+allo-THE+ cortolone) ratios may indicate a decrease of 11β-hydroxysteroiddehydrogenase type 2 activity in patients with РНЕО.

Cite this article

Download citation ▾

M A Ivanushko, N V Vorokhobina, L I Velikanova, Z R Shafigullina. CHARACTERISTICS OF METABOLISM OF GLUCOCORTICOID HORMONESIN PATIENTS WITH PHEOCHROMOCYTOMA. HERALD of North-Western State Medical University named after I.I. Mechnikov, 2017, 9(3): 59-64 DOI:10.17816/mechnikov20179359-64

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Adler J.T. Pheochromocytoma: current approaches and future directions/ J.T. Adler, G.Y. MeyerRochow, H. Chen [et al] // Oncologist. - 2008. - Vol. 13. - № 7- P. 779-793.

[2]	NguyenMartin M.A. Pheochromocytoma: An Update on Risk Groups, Diagnosis and Management / M.A. NguyenMartin, G.D.Hammer // Hospital Physician. - 2007. - Vol. 42. - № 2.- P. 17-24.

[3]	Negro A. Severe ectopic Cushing's syndrome due to ACTHsecreting pheochromocytoma / A. Negro, E. Manicardi, C. Grasselli [et al] // Int J Clin Med. - 2013. - Vol. 4. - P. 228-231.

[4]	Taimur S.D. Pheochromocytoma with hypertensive crisis due to glucocorticoid administration: a case report and review of the literature / S.D. Taimur, M.R. Karim, M.H. Rahman [et al] // Bangladesh Journal of Medical Science. - 2011. - Vol. 10. - P. 213-215.

[5]	Ramasamy M. Adrenocorticotrophic hormone secreting pheochromocytoma / M. Ramasamy, R. Thiagarajan, P. Dass // Indian Journal of Urology. - 2010. - V. 26. - № 1. - Р. 123-125.

[6]	KirkbyBott J. Ectopic hormonesecreting pheochromocytoma: a francophone observational study / J. KirkbyBott, L. Brunaud, M. Mathonet [et al] // World journal of surgery. - 2012. - V. 36. - № 6. - Р. 1382-1388.

[7]	Yu R. Diagnosis and treatment of pheochromocytoma in an academic hospital from 1997 to 2007 / R. Yu., N. Nissen., P. Chopra [et al] // Am J Med. - 2009 - Vol. 122. - № 1. - P. 85-95.

[8]	Trimeche A.S. Corticomedullary mixed tumor of the adrenal gland / A.S. Trimeche, M. Chadli Chaieb, M. Mokni [et al] // Ann Endocrinol (Paris). - 2009. - V. 70. - P. 473-476.

[9]	Chen H. Adrenocorticotropic hormonesecreting pheochromocytomas: the exception to the rule / H. Chen, J.L. Doppman, G.P. Chrousos [et al] // Surgery. - 1995. - V. 118 - P. 988-994.

[10]	Дедов И.И. Эндокринология / И.И. Дедов, Г.A. Мельниченко, В.В. Фадеев // М.: ГэотарМед. - 2007. - 422 с.