ROLE OF CYTOKINE ACTIVATION IN THE DEVELOPMENT OF CARDIOVASCULARDISORDERS IN PATIENT WITH GRAVES DISEASE AND CHRONIC HEART FAILURE

A V Frolova; T I Rodionova

doi:10.17816/mechnikov20157274-77

HERALD of North-Western State Medical University named after I.I. Mechnikov ›› 2015, Vol. 7 ›› Issue (2) :74 -77. DOI: 10.17816/mechnikov20157274-77

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ROLE OF CYTOKINE ACTIVATION IN THE DEVELOPMENT OF CARDIOVASCULARDISORDERS IN PATIENT WITH GRAVES DISEASE AND CHRONIC HEART FAILURE

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Abstract

The aim of the study is to assess the ability to influence immunological changes on the formation of cardiovascular complications of hyperthyroidism by determining the level of thyrotropin-receptor antibodies (TRAb), 6,8,10 interleukins (IL-6,8,10) and tumor necrosis factor-alpha (TNF-) in patients with Graves’ disease (Gd) and chronic heart failure (CHF) and without it. 68 patients were investigated with Gd, CHF diagnosed in 38 patients (55.9%), stage 1- in 12 patients (31.6%), stage 2A - in 19 (50%) patients, stage 2B - in 7 (18,4%) patients. For the analysis, patients were divided into 3 groups: 1 - with no signs of heart failure, 2 with CHF 1 stage (because the clinical signs characteristic of heart failure stage 1 can also be symptoms of hyperthyroidism, these patients were in separate group), 3 - CHF 2A and step 2B. In all three patients groups showed a significant increase in the levels of cytokines and TRAb compared with the control group. The development of CHF in patients with Graves’ disease is associated with increasing of IL-6, IL-8 and IL-10 concentration. direct correlation between the level of TRAb, TNF- and development of the cardiovascular complications in patients with Gd have not been identified.

Keywords

Graves disease / chronic heart failure / thyrotropin-receptor antibodies / cytokines

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A V Frolova, T I Rodionova. ROLE OF CYTOKINE ACTIVATION IN THE DEVELOPMENT OF CARDIOVASCULARDISORDERS IN PATIENT WITH GRAVES DISEASE AND CHRONIC HEART FAILURE. HERALD of North-Western State Medical University named after I.I. Mechnikov, 2015, 7(2): 74-77 DOI:10.17816/mechnikov20157274-77

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