STUDY THE REGULATION OF PERIPHERAL BLOOD FLOW IN PATIENTSWITH CARDIOVASCULAR DISORDERS

A G Manasyan; A L Dobkes; S G Manasyan; S U Ermolov; S V Serdyukov; S A Boldueva; A S Lipunova; T V Ermolova; O V Zaxarova; D N Nikitin

doi:10.17816/mechnikov20157252-62

HERALD of North-Western State Medical University named after I.I. Mechnikov ›› 2015, Vol. 7 ›› Issue (2) :52 -62. DOI: 10.17816/mechnikov20157252-62

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STUDY THE REGULATION OF PERIPHERAL BLOOD FLOW IN PATIENTSWITH CARDIOVASCULAR DISORDERS

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Abstract

A new approach to evaluating of the state of cardiovascular system for patients with verified diagnosis of coronary heart disease (CHd), cardiac syndrome X (COAG) and hypertension (GB) by modification of known techniques of the PAT (peripheral arterial tonometry) is represented in the article. The results of studies by the method of us PAT patients with various cardiovascular disease indicate a particular clinical significance is not only the assessment of local «endothelial dysfunction» (the known value of reactive hyperemia index RHI), but also assess the nature of the Central system response regulation of blood circulation. In the article it is shown that more convenient for this relatively simpleCtrlmeasure R(relative change in the amplitude of pulsations in case of occlusion of the blood supplyto the sample identified on the hand are not subjected to occlusion). For patients without evidenceCtrlof cardiovascular disease the index value Rwas close to unity. The hypertensive patients, as a rule,observed values of R<1, and in CHd patients, in contrast, R>1. The differences associated, pre-CtrlCtrlsumably, with the changing balance between the degree of disturbance of peripheral blood circulationand degree of preservation of the reserves of the pumping function of the heart. This allows to consider the index RCtrl as an additional feature, an essential for individual selection of therapy in patients with cardiovascular pathology.

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peripheral blood / endothelium-dependent vasodilation / ischemic heart disease / hyper- tension / cardiac syndrome X

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A G Manasyan, A L Dobkes, S G Manasyan, S U Ermolov, S V Serdyukov, S A Boldueva, A S Lipunova, T V Ermolova, O V Zaxarova, D N Nikitin. STUDY THE REGULATION OF PERIPHERAL BLOOD FLOW IN PATIENTSWITH CARDIOVASCULAR DISORDERS. HERALD of North-Western State Medical University named after I.I. Mechnikov, 2015, 7(2): 52-62 DOI:10.17816/mechnikov20157252-62

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