DYNAMICS OF CYTOKINS AND THEIR INTERRELATION IN LIVER CIRRHOSIS

B B Fishman; M A Toneeva; V E Kulikov; V A Kornilova; E R Antonova

doi:10.17816/mechnikov201571110-114

HERALD of North-Western State Medical University named after I.I. Mechnikov ›› 2015, Vol. 7 ›› Issue (1) :110 -114. DOI: 10.17816/mechnikov201571110-114

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DYNAMICS OF CYTOKINS AND THEIR INTERRELATION IN LIVER CIRRHOSIS

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Abstract

The research objectives are to determine serum interleukins (IL-2, IL-6) and tumor necrosis factor alpha (TNF - α) and evaluate their interrelation in liver cirrhosis (class A, B, C according to Chad - Pugh). 117 patients were examined and their cytokines levels were determined using enzyme-linked immunosorbent assay.Elevation of cytokine levels IL-2, I-6 and TNF-α within reference values was found in liver cirrhosis cases, expect for level IL-6 in liver cirrhosis cases of class C. In these cases IL-6 level exceeds reference values and is within the limit of 9,94 - 25,21 pg / ml with average concentration of 14,89±4,96 pg / ml. Correlation is found between TNF- α and IL-6 (r = - 0,499) in liver cirrhosis of class A and correlation between TNF- α and IL-2 (r = 0,421) is found in liver cirrhosis of class B.

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interleukin-2 / interleukin-6 / tumor necrosis factor alpha / cirrhosis of liver

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B B Fishman, M A Toneeva, V E Kulikov, V A Kornilova, E R Antonova. DYNAMICS OF CYTOKINS AND THEIR INTERRELATION IN LIVER CIRRHOSIS. HERALD of North-Western State Medical University named after I.I. Mechnikov, 2015, 7(1): 110-114 DOI:10.17816/mechnikov201571110-114

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