SQUAMOUS CELL PRECANCEROUS LESIONS OF THE VULVA: CURRENT PROBLEMS OF CLASSIFICATION AND DIAGNOSIS

Abstract

This article systematizes and analyzes objective difficulties in the diagnosis of precancerous and primary vulva cancer, such as: constant changes in classification and long-term coordination, long-term systematization of clinical manifestations. It also reflects the current data and achievements of virology and molecular biology, which again led to a change in the classification and approaches to the diagnosis and management tactics of patients with squamous cell lesions of the vulva. New predictor markers, currently available for use in conventional routine morphological practice, gave new data on the development of pre-tumor and tumor process of the external genitals. Also in this article, the new clinical classification of vulva diseases is analyzed in detail, a comparison of standard and new diagnostic methods is carried out, which in clinical practice helps to correctly diagnose, determine the extent of the lesion and, depending on the molecular factors of the prognosis, choose an individual modern treatment tactics.

Keywords

squamous intraepithelial lesion / kraurosis vulvae / lichen sclerosus / vulvar intraepithelial neoplasia (VIN) / human papillomavirus (HPV) / squamous cell carcinomas (SCC) of the vulva / diagnosis

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