ATYPICAL HEMOLYTIC-UREMIC SYNDROME DURING PREGNANCY. PRESENT AND LATEST RESULTS OF TREATMENT
N. A Zharkin , M. E Statsenko , M. M Stazharova , Natalia A. Burova , S. A Prokhvatilov
V.F.Snegirev Archives of Obstetrics and Gynecology ›› 2019, Vol. 6 ›› Issue (1) : 47 -50.
ATYPICAL HEMOLYTIC-UREMIC SYNDROME DURING PREGNANCY. PRESENT AND LATEST RESULTS OF TREATMENT
Atypical hemolytic-uremic syndrome being referred to autoimmune diseases appears to be one of the most severe forms of thrombosis and microangiopathy. Difficulties in diagnosis cause a delay in pathogenetic therapy, which causes a high maternal mortality rate. Pathogenetic therapy with eculizumab, suppressing the terminal activity of complement, may contribute to the recovery of blood coagulation properties, but the long-term prognosis for chronic renal failure remains unfavorable. The article deals with a clinical case confirming this conclusion.
atypical hemolytic uremic syndrome / acute kidney damage / complement / plasma infusion / postpartum period / hemostasis inactivation factor / eculizumab / renal dialysis / thrombotic microangiopathy
| [1] |
Elayoubi J., Donthireddy K., Nemakayala D.R. Microangiopathies in pregnancy. BMJ Case Rep. 2018; doi: 10.1136/bcr-2017-221648 |
| [2] |
Распопин Ю.С., Колесниченко А.П., Синявская Н.В., Миллер А.А., Шифман Е.М., Куликов А.В. Многоликая тромботическая микроангиопатия - «ожерелье смерти» осложнений беременности и родов. Клиническая нефрология. 2017; (2): 32-6. |
| [3] |
Калачин К.А., Грищук К.И., Шмаков Р.Г., Пырегов А.В., Федорова Т.А. «Нетипичный» HELLP-синдром или атипичный гемолитико-уремический синдром? Акушерство и гинекология. 2017; (1): 94-102. DOI: 10.18565/aig.2017.1.94-102 |
| [4] |
Silver R.M. Catastrophic antiphospholipid syndrome and pregnancy. Semin. Perinatol. 2017; doi: 10.1053/j.semperi.2017.11.006 |
| [5] |
Fox L., Cohney S.J., Kausman J.Y., Shortt J., Hughes P.D., Wood E.M. et al. Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand. Nephrology (Carlton). 2018; doi: 10.1111/nep.13234 |
| [6] |
De Souza V.R., Jr, Cavalcante de Oliveira A.B., Vanderlei A.M., Queiroz da Mota A., Aroucha S., Duarte B.P. et al. Inherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report. J. Med. Case Report. 2018.12.15. Published On Line Jan. 2018, doi: 10.1186/s13256-017-1545-3 |
| [7] |
Cravero R., Ardissino G., Colageo U., Staffa P., Bruschetta E., Maroni S. et al. Efficacy of eculizumab in a case of pregnancy-associated aHUS. G. Ital. Nefrol. 2016 Jul-Aug; 33(4). PMID: 27545639 |
| [8] |
Пронина И.С. Трудный диагноз: аГУС, ассоциированный с родами. Bulletin of Medical Internet Conferences (ISSN 2224-6150). 2016; 6 (5): 542. ID: 2016-05-8-T-6680 |
| [9] |
Зефирова Т.П., Мальцева Л.И., Замалеева Р.С., Железова М.Е. Синдром тромботической микроангиопатии при угрожающих жизни осложнениях беременности и родов у женщин. Практическая медицина. 2017; 7(108): 26-30. |
| [10] |
Skully M. Thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome microangiopathy in pregnancy. Semin. Thromb. Hemost. 2016; 42(7): 774-9. Epub 2016 Sep 20. |
| [11] |
Bruel A., Kavanagh D., Noris M., Delmas Y., Wong E.K.S., Bresin E. et al. Hemolytic uremic syndrome in pregnancy and postpartum. Clin. J. Am. Soc. Nephrol. 2017; 12(8):1237-47. doi: 10.2215/CJN.00280117. |
| [12] |
Cines D.B., Levine L.D. Thrombocytopenia in pregnancy. Hematology Am. Soc. Hematol. Educ. Program. 2017; (1):144-51. doi: 10.1182/asheducation-2017.1.144 |
Eco-Vector
/
| 〈 |
|
〉 |
PDF
