METHODS OF PRECLINICAL DIAGNOSIS OF PREECLAMPSIA. COMPARISON OF BIOCHEMICAL AND INSTRUMENTAL METHODS OF EXAMINATION

Abstract

The review presents current information on the predictive diagnosis of preeclampsia. The data of instrumental and laboratory diagnostics are described. Laboratory diagnostics includes such biochemical markers as PAPP-A, PIGF, VEGF, sFlt-1, sEng, NSE; instrumental diagnostics consists of ultrasound evaluation of placental structure, ultrasound dopplerometry of uterine arteries and determination of the index of vascularization of the placenta. Not all methods of the examination presented by the author have diagnostic value in the clinical use. Biochemical markers present the most accurate diagnostic picture. It is necessary to evaluate sFlt-1, PIGF and other markers in dynamics since their change with the increase in the gestation age differs significantly from the change in those in women with normal pregnancy.

Keywords

preeclampsia / screening / placental growth factor / markers / fms-like tyrosine kinase-1 / vascular endothelial growth factor / dopplerometry of uterine arteries

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