“Obstetrical” atypical hemolytic-uremic syndrome: difficult diagnosis?
Yu. V Korotchaeva , N. L Kozlovskaya , T. V Bondarenko , G. A Veselov
V.F.Snegirev Archives of Obstetrics and Gynecology ›› 2015, Vol. 2 ›› Issue (2) : 36 -41.
“Obstetrical” atypical hemolytic-uremic syndrome: difficult diagnosis?
A case rare aGUS that developed late in the second trimester of pregnancy, and showed severe multiple organ pathology, including the kidneys, heart, lungs, nervous system and the placenta. As a result, early diagnosis and timely plazmotherapy started in conjunction with LMWH acute TMA eliminated with full restoration offunction of damaged organs.
thrombotic microangiopathy / atypical hemolytic uremic syndrome / pregnancy
| [1] |
Tsai H.M. A Mechanistic approach to the diagnosis and management of atypical hemolytic uremic syndrome. Transfus. Med. Rev. 2014; 28 (4): 187-97. |
| [2] |
Fakhouri F., Fremeaux-Bacchi V. Does hemolytic uremic syndrome differ from thrombotic thrombocytopenic purpura. Nat. Clin. Pract. Nephrol. 2007; 3: 679-87. |
| [3] |
Noris M., Giuseppe R. Atypical hemolytic-uremic syndrome. N. Engl. J. Med. 2009; 361: 1676-87. |
| [4] |
Fakhouri F., Vercel C., Frémeaux-Bacchi V. Obstetric nephrology: AKI and thrombotic microangiopathies in pregnancy. Clin. J. Am. Soc. Nephrol. 2012; 7 (12): 2100-6. |
| [5] |
Meri S. Complement activation in diseases presenting with thrombotic microangiopathy. Eur. J. Intern. Med. 2013; 24 (6): 496-502. |
| [6] |
McMinn J.R., George J.N. Evaluation of women with clinically suspected thrombotic thrombocytopenic purpura-hemolytic uremic syndrome during pregnancy. J. Clin. Apher. 2001; 16: 202-9. |
| [7] |
Fakhouri F., Roumenina L., Provot F., Sallée M., Caillard S., Couzi L. et al. Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J .Am. Soc. Nephrol. 2010; 21: 859-67. |
| [8] |
Sanches-Luseros A., Farias С. Von Willebrand factor-cleaving protease (ADAMTS-13) activity in normal non-pregnant women, pregnant and postdelivery women. Thromb. Haemost. 2004; 92: 1320-6. |
| [9] |
Owens M.Y., Martin J.N.Jr., Wallace K., Keiser S.D., Parrish M.R., Tam Tam K.B. et al. Postpartum thrombotic microangiopathic syndrome. Transfus. Apher. Sci. 2013; 48 (1): 51-7. |
| [10] |
Han-Mou Tsai. Untying the knot of thrombotic thrombocytopenic purpura and atypical hemolytic uremic syndrome. 2013; 126 (3): 200-9. |
| [11] |
Козловская Н.Л., Меркушева Л.И., Кирсанова Т.В., Рунихина Н.К. Особенности течения и исхода атипичного гемолитико-уремического синдрома при беременности. Клиническая нефрология. 2012; 3: 44-9. |
| [12] |
Noris M., Caprioli J., Bresin E., Mossali C., Pianetti G., Gamba S. et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin. J. Am. Soc. Nephrol. 2010; 5: 1844-59. |
| [13] |
Noris M., Remuzzi G. Thrombotic microangiopathy after kidney transplantation. Am. J. Transplant. 2010; 10 (7): 1517-23. |
| [14] |
Ganesan C., Maynard S.E. Acute kidney injury in pregnancy: the thrombotic microangiopathies. J. Nephrol. 2011; 24: 554-63. |
| [15] |
Amara U., Rittrisch D., Flierl M., Bruckner U., Klos A., Gebhard F. et al. Interaction between the coagulation and complement system. Adv. Exp. Med. Biol. 2008; 632: 71-9. |
| [16] |
Козловская Н.Л. Низкомолекулярные гепарины в практике нефролога. Клиническая нефрология. 2011; 1: 15-22. |
| [17] |
Loirat C., Garnier A., Sellier-Leclerc A.L., Kwon T. Plasmatherapy in atypical hemolytic uremic syndrome. Semin. Thromb. Hemost. 2010; 36: 673-81. |
Eco-Vector
/
| 〈 |
|
〉 |
PDF
