Vaginal microbiocenosis in patients with HPV-associated and HPV-negative cervical intraepithelial neoplasias

Abstract

Vaginal microbiocenosis was studied in 311 patients with cervical intraepithelial neoplasias (CIN) by RT-PCR (Femoflor-16 test, DNA-Technologies). The results indicated that HPV-asociated and HPV-negative CIN were associated with the development of pronounced vaginal dysbiosis caused by mainly obligate anaerobes, predominantly Gardnerella vaginalis in associations with Atopobium vaginae, Megasphaera spp./Veillonella spp./Dialister spp., and Eubacterium spp. A great variety of the agents dictated comprehensive studies of the vaginal microbiocenosis in patients with cervical precancer conditions in order to prescribe individual therapy.

Keywords

LSIL / HSIL / vaginal microbiocenosis / anaerobic dysbiosis / cervical intraepithelial neoplasias / LSIL / HSIL

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