β-Lactamase activity in the amniotic fluid

A. S Zanko; D. M Semyonov

doi:10.17816/aog35259

V.F.Snegirev Archives of Obstetrics and Gynecology ›› 2015, Vol. 2 ›› Issue (1) : 18 -21. DOI: 10.17816/aog35259

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β-Lactamase activity in the amniotic fluid

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Abstract

Beta-lactamase activities were measured in the amniotic fluid and serum of pregnant women. The relationship between the parameters was analyzed and the clinical significance of biological resistance to beta-lactam antibiotics in this patient population was evaluated. A total of 40 women were distributed into groups by the following parameters: pregnancy (pregnant/nonpregnant), gestation term, and inflammatory process (present/not). Serum beta-lactamase activity was measured by the Biolactam test system. All patients exhibited beta-lactamase activities in the amniotic fluid and serum. High level of the blood beta-lactamase activity is a factor preventing effective therapy by beta-lactam antibiotics. Hence, evaluation of biological resistance to beta-lactam antibiotics before therapy prevents their unjustified prescription and improves the treatment efficiency.

Keywords

beta-lactam antibiotics / pregnancy / biological resistance / Biolactam

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A. S Zanko, D. M Semyonov. β-Lactamase activity in the amniotic fluid. V.F.Snegirev Archives of Obstetrics and Gynecology, 2015, 2(1): 18-21 DOI:10.17816/aog35259

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