Influence of ADRB2 gene polymorphism on the development of preterm birth in women of different ethnic groups

Abstract

Preterm birth remains an acute medical and socio-economic problem. The successful course of pregnancy and its completion by timely delivery is directly dependent on an adequate balance of immune interactions between the mother and the fetus throughout the pregnancy, respectively, any failure of this system can lead to catastrophic consequences. The level of cytokine expression is genetically determined. Polymorphism of a gene affects the level of cytokines in its expression and functionality. Thus, polymorphism of cytokine genes can have an effect on the development of various pregnancy complications leading to its premature termination.

Keywords

preterm birth / tocolytic therapy / ADRB2 gene polymorphism

References

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