Human placenta as a source of hematopoietic stem cells

V. Serikov; F. Kuypers

doi:10.23868/gc158689

Genes & Cells ›› 2008, Vol. 3 ›› Issue (2) : 51 -56. DOI: 10.23868/gc158689

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Human placenta as a source of hematopoietic stem cells

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Abstract

То date, only a fraction of transplantation patients, however, have access to immunologically-matched HSCs. Bone marrow, peripheral blood, and umbilical cord blood (CB) are current sources of HSCs for transplantation. While СВ-derived stem cells have many advantages, their number in a single unit is insufficient for transplantation of an adult patient. Here we show that tissue of human term placenta contains large numbers of CD34⁺-CD133⁺ HSCs, which are not part of the fetal or maternal circulation. The number of these placental HSCs in a single unit exceeds by 10-fold the number of HSCs in a CB unit. Cells obtained from either fresh or preserved frozen placental tissue gave rise to erythroid and myeloid lineages in cell culture and lymphoid lineages in immunodeficient mice. Thus, preserved placenta could serve as a potential source for reconstituting hematopoiesis in adult humans.

Keywords

placenta / hemopoiesis / hematopoietic stem cells / transplantation

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V. Serikov, F. Kuypers. Human placenta as a source of hematopoietic stem cells. Genes & Cells, 2008, 3(2): 51-56 DOI:10.23868/gc158689

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