Transplantation of two HLA-compatible umbilical cord blood units as a modern approach to solving the problem of a small number of cells and an alternative to allogeneic bone marrow transplantation in leukemia in adult patients

Abstract

Umbilical cord blood cell transplantation [PC], as an alternative to unrelated bone marrow transplantation [TCM], has already firmly taken its place in oncohematology. The main advantages of PC transplantation, in comparison with TCM, include a lower incidence of the "graft-versus-host reaction" [GVHD] and a more liberal approach to the degree of HLA compatibility of the graft with an equal post-transplant prognosis, however, with PC transplantation, a lower engraftment and an increased likelihood of recurrence are noted [1,2].

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