Endogenous secretion of vascular endothelial growth factor by multipotent mesenchymal stromal cellsderived from human third molar dental follicles

V V Solovyeva; N L Blatt; A K Shafigullina; A A Rizvanov

doi:10.23868/gc121668

Genes & Cells ›› 2012, Vol. 7 ›› Issue (3) : 155 -158. DOI: 10.23868/gc121668

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Endogenous secretion of vascular endothelial growth factor by multipotent mesenchymal stromal cellsderived from human third molar dental follicles

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Abstract

Human stem cells secretome is currently a very hot areaof research. We report that multipotent mesenchymal stromalcells isolated from human third molar dental follicles (MMSCTMDF),are able to secrete high levels of vascular endothelialgrowth factor (VEGF) when cultured in vitro. Due to the factthat VEGF is a well known angiogenic and neuroprotectivefactor, the use of MMSC-TMDF is promising for thedevelopment of stem cell therapy of various degenerativehuman diseases.

Keywords

secretome / multipotent stem cells / third molar dental follicles / vascular endothelial growth factor

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V V Solovyeva, N L Blatt, A K Shafigullina, A A Rizvanov. Endogenous secretion of vascular endothelial growth factor by multipotent mesenchymal stromal cellsderived from human third molar dental follicles. Genes & Cells, 2012, 7(3): 155-158 DOI:10.23868/gc121668

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