Regulation development of bone marrow postnatal stem cells by specific xenogenic immune globulins

Abstract

The regulation development of haemopoietic stem cells byrabbit anti-human CD34+ stem cells immune globulin has beenestablished. It was showed by experimental investigation onrats with cytostatic haemo-immunosuppression and in culturehuman CD34+ stem cells. Thus, in animals which receivedanti-CD34+ immune globulin the recovery of blood andimmunity values occurred earlier than in the control animals.The experimental animals recovered haemolymphocytopoiesisafter one month while control group normalized haemopoieticfunction after two months. In vitro colony-forming abilityhuman haemopoietic stem cells are increased in 30 per centby the addition specific CD34+ immune globulin in counditionedmedium. Our preliminary date suggest that rabbit anti-humanmesenchymal stem cells immune globulin can stimulate thedifferentiation of mesenchymal cells in osteoblasts andendotheliocytis the cells that form haemopoietic niche.

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