Modern strategies of regenerative therapy and safety of allogenous human umbilical cord blood stem cellsadministration for neurodegenerative diseases

Abstract

Biotechnological market in harvesting and application ofumbilical cord blood stem cells, is permanently developing inthe world. Efficiency of regenerative therapy, based on useof cord blood stem cells depends on the number and diversityof HLA-typed cord blood units. Human umbilical cord blood isa genuine source of the stem cells rich biological material,important for human. 114 patients with neurodegenerativediseases were transplanted with allogenic umbilical cordblood. Cord blood stem cells were used without selection byHLA antigens, but only by ABO blood group and Rh factor. Thepossibility of using of allogenic umbilical cord blood stem cellsin regenerative therapy, and the lack of immunosupressionwill overcome significant obstacles existing in cell therapy todate. In practical terms, its becoming clear that extensiveapplication of allogenic umbilical cord blood stem cellsregenerative therapy will seriously changes approaches to thedevelopment and delivery of umbilical blood stem cells-baseddrugs existing nowadays and approved by many generationsof doctors.

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