Autophagy induction in peripheral blood T-lymphocytes of atopic asthma patients

Abstract

Autophagy is a fundamental process that ensuresthe regulation of T-cell homeostasis. In case of apoptosisinduction disruption in the cell it could be single mechanism ofthe cell death. Previously was shown inhibition of lymphocyteapoptosis in patients with bronchial asthma, so the main studyof this work has focused on the study development processof autophagy in T-lymphocytes of patients with bronchialasthma. The article presents the main morphological changesin cells associated with activation of autophagy (formationautophagosome). In addition to morphological changes inlymphocytes, we have shown the expression of autophagymarker protein (LC3B). We found that in T-lymphocytes ofpatients with severe asthma are simultaneous activation ofboth autophagy and apoptosis, and autophagy is a stimulusto cell death.

Keywords

autophagy / apoptosis / T-lymphocytes / asthma / LC3B protein

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