C-kit-positive pancreas islets cell of rats pancreas as a endocrine cells progenitor during alloxan diabetes

A S Plyushkina; M S Kaligin; D I Andreeva; A A Titova; I Kh Valeeva; A V Dem'yanov; A A Gumerova; A P Kiyasov; A S Plushkina; M S Kaligin; D I Andreeva; A A Titova; I H Valeeva; A V Demyanov; A A Gumerova; A P Kiassov

doi:10.23868/gc121645

Genes & Cells ›› 2012, Vol. 7 ›› Issue (3) : 138 -141. DOI: 10.23868/gc121645

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C-kit-positive pancreas islets cell of rats pancreas as a endocrine cells progenitor during alloxan diabetes

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Kazan State Medical University, Kazan

Kazan (Volga Region) Federal University, Kazan

Kazan State Medical University, Kazan

Kazan State Medical University, Kazan;Kazan (Volga Region) Federal University, Kazan;

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Abstract

One of the most common markers for stem cells inpancreas is the stem cell factor receptor C-kit (CD117) thatplays a main role in differentiation of progenitor endocrinecells of pancreas islets in prenatal development and persistsafter birth. But still the role of C-kit positive cells in islet-cells regeneration during the diabetes mellitus type I hasnot been studied. Thats why the aim of our work was tostudy the dynamic of C-kit expression in the pancreas isletsduring the experimental alloxan diabetes in rats. The workwas made on 33 rats with the experimental diabetes. Bloodglucose levels, levels of insulin and glucagon were measured.And also we studied the expression of C-kit, insulin andglucagon in rat pancreas. The results of the study showedthe C-kit expression after one day of the experimentalhyperglycemia. These cells were also expressed insulin andglucagon. We suppose that C-kit+-cells, which produceinsulin, were enable to correct disrupted carbohydratemetabolism during alloxan diabetes.

Keywords

pancreas / progenitor cells / stem cell factor receptor / diabetes mellitus

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A S Plyushkina, M S Kaligin, D I Andreeva, A A Titova, I Kh Valeeva, A V Dem'yanov, A A Gumerova, A P Kiyasov, A S Plushkina, M S Kaligin, D I Andreeva, A A Titova, I H Valeeva, A V Demyanov, A A Gumerova, A P Kiassov. C-kit-positive pancreas islets cell of rats pancreas as a endocrine cells progenitor during alloxan diabetes. Genes & Cells, 2012, 7(3): 138-141 DOI:10.23868/gc121645

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References

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[1]	Калигин М.С., Гумерова А.А, Титова М.А. и др. C-kit маркёр стволовых клеток эндокриноцитов поджелудочной железы. Морфо- логия 2011; 140(4): 32-7.

[2]	Закирьянов А.Р., Онищенко Н.А. Возможные пути реализации регенерационной стратегии при лечении сахарного диабета I типа методами клеточной трансплантации. Клеточная трансплантология и тканевая инженерия 2007; 2(II): 23-33.

[3]	Баранов В.Г., Соколоверова И.М., Гаспарян Э.Г. Эксперимен- тальный сахарный диабет. Роль в клинической диабетологии. Л.: Наука; 1983.

[4]	Дедов И.И., Мельниченко Г.А., Фадеев В.Ф. Эндокриноло- гия. М.: ГЭОТАР-Медиа; 2007.

[5]	Орехович В.Н. Современные методы в биохимии. М.: Наука; 1977.

[6]	Herrera P.L., Huarte J., Zufferey R. et al. Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. PNAS USA 1994; 91: 12999-3003.

[7]	Jensen J., Heller R.S., Funder-Nielsen T. et al. Independent development of pancreatic - and -cells from neurogenin3-expressing precursors a role for the notch pathway in repression of premature differentiation. Diabetes 2000; 49: 163-76.