Post-traumatic reactions of a rat spinal cord after transplantation of human olfactory mucosa cells

G F Shajmardanova; Ju A Chelyshev; S V Lebedev; E A Savchenko; I V Viktorov; A V Karasjov; V P Chehonin

doi:10.23868/gc121644

Genes & Cells ›› 2012, Vol. 7 ›› Issue (2) : 92 -96. DOI: 10.23868/gc121644

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Post-traumatic reactions of a rat spinal cord after transplantation of human olfactory mucosa cells

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Kazan Institute of Biochemistry and Biophysics KSC RAS, Kazan

Kazan State Medical University, Kazan3 Kazan (Volga region) Federal University, Kazan

V.P. Serbsky State Scientific Center for Social and Forensic Psychiatry, Moscow

Kazan Institute of Biochemistry and Biophysics KSC RAS, Kazan

Kazan State Medical University, Kazan3 Kazan (Volga region) Federal University, Kazan

V.P. Serbsky State Scientific Center for Social and Forensic Psychiatry, Moscow

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Abstract

In the model of adult rat spinal cord contusion on the Th9level effect of the immediate transplantation of the humanolfactory mucosa cell into the damaged area were studied.No immunosuppression was used. It was shown thattransplanted cells were survived as long as 7 days aftertransplantation and located in rostral and caudal directions inwhite matter on the 2 mm distance from points of injections.It was shown also that transplanted cells migrated intoperipheral zone of the damaged area. The size of damagedarea in white and especially in gray matters were decreasedafter 30 and 60 days after transplantation. The same timeafter 30 days after transplantation the size of pathologicalcavities mostly in anterior column were obviously diminishedand that number of undamaged myelinated nerve fibers wereincreased in number around the area of transplantation

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G F Shajmardanova, Ju A Chelyshev, S V Lebedev, E A Savchenko, I V Viktorov, A V Karasjov, V P Chehonin. Post-traumatic reactions of a rat spinal cord after transplantation of human olfactory mucosa cells. Genes & Cells, 2012, 7(2): 92-96 DOI:10.23868/gc121644

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