Quantative effect of improving osteoinductive property of a material due to applicationof recombinant morphogenetic bone protein rhВМР-2

Abstract

At present, novel osteoinductive materials containingrecombinant bone morphogenetic proteins (rhBMPs) areactively being developed for «regenerative medicine»,traumatology and orthopedics. To evaluate the effectof rhBMPs in materials, the great interest is to studyosteoinductive properties of the materials in experimentalmodels in vivo. In this paper we show that application of bonemorphogenetic protein rhBMP-2 in demineralized cancellousbone blocks provides great improving osteoinductivity of thematerial in the ectopic model subcutaneous implantation inrats. This improvement was reflected in multifold accelerationof mineralization and in active forming a new structuredcollagen matrix in the material. The model of ectopicsubcutaneous implantation to rats is very convenience testsystem to detect increase in osteoinductivity of materialscaused by application of rhBMP-2, and to identify features ofectopic bone formation in these materials.

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