Histogenesis of epithelial and stromal components at ductal adenocarcinoma of the pancreas

G. R Setdikova; O. V Paklina; I. A Chekmareva; E. N Gordienko

doi:10.23868/gc121621

Genes & Cells ›› 2013, Vol. 8 ›› Issue (4) : 78 -81. DOI: 10.23868/gc121621

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Histogenesis of epithelial and stromal components at ductal adenocarcinoma of the pancreas

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Abstract

The aim of our research is to define the morphological properties of anaplastic tumor site and surrounding stroma in ductal pancreatic cancer.The epithelial- stromal interactions in ductal pancreatic cancer cause its aggressive biological behavior, resistance to chemotherapy and survival of different depending on tumor differentiation. Heterogeneity of ductal carcinoma manifested in the appearance of anaplastic (sarcomatoid) component, which outlined the ability of epithelial tumor cells acquire the property of mesenchymal cells, which do not require the stroma and have aggressive malignant potential that influences the survival of patients .

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ductal adenocarcinoma / pancreas / anaplastic carcinoma / epithelial-to-mesenchymal transition

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G. R Setdikova, O. V Paklina, I. A Chekmareva, E. N Gordienko. Histogenesis of epithelial and stromal components at ductal adenocarcinoma of the pancreas. Genes & Cells, 2013, 8(4): 78-81 DOI:10.23868/gc121621

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