Application of nanocomposite coatings for multipotent mesenchymal stromal cells cultivation technologies

A. N Goltsev; I. V Rassokha; T. G Dubrava; L. V Ostankova; M. V Ostankov; E. A Gordienko; V. I Safonov; AV. V Zykova

doi:10.23868/gc121605

Genes & Cells ›› 2013, Vol. 8 ›› Issue (1) : 46 -50. DOI: 10.23868/gc121605

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Application of nanocomposite coatings for multipotent mesenchymal stromal cells cultivation technologies

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Abstract

The results of experimental research for the effect character of nanocomposite coatings with different physicochemical parameters on structural and functional properties (adhesive potential, phenotype, expression of ido gene) of multipotent mesenchymal stromal cells (MMSCs) are presented in the work. In the whole spectrum of tested nanocoatings (Al 2O 3, ZrO 2, Ta 2O 5) we have established the ability of oxide coating Al2O3 to monolayerly enrich the cultured in vitro bone marrow (BM) with the MMSCs and increase the degree of ido expression. This can expand the spectrum and give them new shapes of therapeutic potential in clinical practice.

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nanocomposite coatings / multipotent mesenchymal stromal cells / ido gene

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A. N Goltsev, I. V Rassokha, T. G Dubrava, L. V Ostankova, M. V Ostankov, E. A Gordienko, V. I Safonov, AV. V Zykova. Application of nanocomposite coatings for multipotent mesenchymal stromal cells cultivation technologies. Genes & Cells, 2013, 8(1): 46-50 DOI:10.23868/gc121605

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