Isolation, culture and differentiation of rat (Rattus norvegicus) and hamster (Mesocricetus auratus)adipose derived multipotent mesenchymal stromal cells
M N Katina , R F Gaifullina , Z G Hayatova , Ch Ch Emene , A A Rizvanov
Genes & Cells ›› 2012, Vol. 7 ›› Issue (3) : 82 -87.
Isolation, culture and differentiation of rat (Rattus norvegicus) and hamster (Mesocricetus auratus)adipose derived multipotent mesenchymal stromal cells
Cell therapy of various diseases is one of the mostperspective fields in modern medicine. Adipose derivedautological stem cells can be obtained for therapeuticpurposes. Animal model of human diseases are essential forcell therapy research. However, the most frequently usedlaboratory animals, such as rats and mice, cant suffer thewhole rate of common diseases of modern society. At thesame time Syrian hamsters can provide scientists with anappropriate animal models of these diseases. Nevertheless,we couldnt find any data on hamsters stem cells isolationand their characteristics. In this study we first isolated Syrianhamsters adipose derived stem cells, characterized theirmorphology, features and differential potential in severalways. These cells are much alike multipotent mesenchymalstromal cells and can go through osteogenic and, adipogenicdifferentiation. We have also shown that these cells candifferentiate in neurogenic way.
multipotent mesenchymal stromal cells / multipotent differentiation / adipogenesis / osteogenesis / neurogenesis / Syrian hamsters
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