С-kit-positive progenitor cells activation in rats pancreas after partial hepatectomy

M S Kaligin; A S Plushkina; I M Gazizov; E I Sharipova; A A Gymerova; A A Kiassov

doi:10.23868/gc121589

Genes & Cells ›› 2012, Vol. 7 ›› Issue (3) : 77 -79. DOI: 10.23868/gc121589

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С-kit-positive progenitor cells activation in rats pancreas after partial hepatectomy

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Abstract

One of the most common markers of pancreas stemcells is a stem cell factor receptor C-kit. According to someauthors, this marker is presented in islet cells of normal ratpancreas. But it is unknown about the behavior of these cells indisorders of carbohydrate metabolism during liver disease. Theaim of our study was to evaluate C-kit expression in pancreasafter partial hepatectomy in rats. Partial hepatectomy wasperformed for 27 white male rats. The expression of C-kit,insulin and glucagon in rats pancreas was studied. Theexpression of C-kit in islets and interstitial cells was shownin results after 3 days of the experiment, and double stainingshowed that these cells can express glucagon. Thus, thereis the activation of C-kit+ progenitor cells in pancreas afterpartial hepatectomy and the beginning of there differentiationto -cells of Langerhance islets.

Keywords

pancreas / partial hepatectomy / stem cellfactor receptor / progenitor cells / islet cells / differentiation

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M S Kaligin, A S Plushkina, I M Gazizov, E I Sharipova, A A Gymerova, A A Kiassov. С-kit-positive progenitor cells activation in rats pancreas after partial hepatectomy. Genes & Cells, 2012, 7(3): 77-79 DOI:10.23868/gc121589

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