Liver pathomorphology of Mus musculus C57BL6 on atherogenic diet

R F Gaifullina; M N Katina; S R Abdulhakov; L R Kasimova; A R Abdulhakova; A A Rizvanov

doi:10.23868/gc121574

Genes & Cells ›› 2012, Vol. 7 ›› Issue (3) : 37 -40. DOI: 10.23868/gc121574

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Liver pathomorphology of Mus musculus C57BL6 on atherogenic diet

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Abstract

Atherosclerosis is one of the leading causes of disabilityand death worldwide. Liver plays a huge role in pathogenesisof atherogenic dislipidemia, development and progression ofatherosclerotic lesions. We studied the effect of atherogenicdiet on liver morphology in animal model of diet-inducedatherosclerosis in mice Mus musculus C57BI6. This strainhas a natural ability to develop atherosclerosis, while someother mouse stains has not. After 14 weeks on atherogenicdiet a severe hepathomegaly (9% of body mass) and lobularstructure deformation was found. We also observed signs ofmicro- and macrovesicular steatosis, cell apoptosis, fibrosisand inflammatory leukocyte infiltration. So, liver not only playsan important role in dislipidemia, but it is also a target-organin lipid metabolism imbalance.

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atherosclerosis / dislipidemia / liver / steatosis / fibrosis / apoptosis / inflammation

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R F Gaifullina, M N Katina, S R Abdulhakov, L R Kasimova, A R Abdulhakova, A A Rizvanov. Liver pathomorphology of Mus musculus C57BL6 on atherogenic diet. Genes & Cells, 2012, 7(3): 37-40 DOI:10.23868/gc121574

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